Immunopathological Features of Canine Myocarditis Associated with<i>Leishmania infantum</i>Infection

Costagliola, Anna; Piegari, Giuseppe; Otrocka-Domagała, Iwona; Ciccarelli, Davide; Iovane, Valentina; Oliva, Gætano; Russo, Valeria; Rinaldi, Laura; Papparella, Serenella; Paciello, Orlando

doi:10.1155/2016/8016186

Cited by 15 publications

(38 citation statements)

References 31 publications

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“…Cardiac involvement in dogs (3,6,7,17) revealed that this protozoan might be also involved in heart, which promptly support the necessity of cardiac evaluation in cases of suspected leishmaniasis.…”

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confidence: 56%

“…La enfermedad puede existir subclínicamente o puede manifestarse como una afección sistémica [lesiones cutáneas, oculares o renales, hepatoesplenomegalia, anemia, atrofia muscular y pérdida de peso] (2). En los últimos 15 años se han reportado signos clínicos de enfermedad cardiaca en relación con leishmaniasis (3)(4)(5)(6), pudiendo existir lesiones miocárdicas (3)(4)(5)(6)(7), por lo que se pudo detectar el parásito en el tejido cardíaco (3,4,6).…”

Section: Introduccionunclassified

“…A recent study reported that myocarditis in CVL (3,5) could be in association within immunological alterations due to Leishmania infection (7). Another study inspected the hearts of 30 dogs naturally infected with Leishmania infantum chagasi, detected myocardial lesions in all dogs, and the parasite was found in the cardiac tissue (20/30 dogs).…”

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confidence: 98%

“…La afectación cardiaca en perros (3,6,7,17) reveló que este protozoario podría estar también implicado en el corazón, lo que prontamente apoya la necesidad de evaluación cardíaca en casos de sospecha de leishmaniasis.…”

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Interpretación de los hallazgos electrocardiográficos, ecocardiográficos y bioquímicos durante las diferentes etapas de la leishmaniasis visceral canina

et al. 2017

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Objective. The purpose of the present study was to test the hypothesis that cardiac alterations participate within different stages of CVL. Materials and methods. Twenty-eight dogs were diagnosed with CVL, were classified [based on clinical signs, rapid ELISA/IFAT, hematological and serum biochemical tests, urinary protein/creatinine ratio, ECG and ECHO]. as follows; group I (mild disease), group II (moderate disease), group III (severe disease), group IV (very severe disease) and group V included healthy controls. Results. Ig G antibodies against leishmaniasis as tested by IFAT, were deemed 1/64 to 1/16000 among infected groups. There were statistical significance regarding mean values for WBC [among healthy control group (V.) and other groups (p=0. No hubo alteración en las concentraciones de CTnI, entre los grupos. El análisis de UPC reveló diferencia estadística entre el grupo control y los perros de estadio II a IV (p=0.000). Se detectaron alteraciones ECG moderadas o severas en 6/28 de los perros enfermos. En cuanto al examen ECHO, el valor LA / Ao presentó diferencias significativas (p=0.003) entre los grupos IV y otros. Conclusiones. Se puede sugerir que el establecimiento del Grupo de Trabajo de Leishvet a los de los perros clasificados en estadios I a IV, ECG [aumento de la aurícula / ventrículo izquierdo, hipoxia miocárdica] y ECHO [dilatación auricular izquierda, disminución / aumento de los LVID, Y la EF (disfunción sistólica)] alteraciones deben tomarse en cuenta junto con el análisis hematológico y bioquímico del suero.

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confidence: 56%

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confidence: 98%

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Interpretación de los hallazgos electrocardiográficos, ecocardiográficos y bioquímicos durante las diferentes etapas de la leishmaniasis visceral canina

et al. 2017

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“…Regarding ventricular repolarization, 50% of the dogs afflicted by cytopenic CME presented higher values for the T-wave, exceeding the rates described for animals afflicted by non-cytopenic CME [9]. This may be explained by the profile of anemia and heart disease.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis

et al. 2019

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Canine Monocytic Ehrlichiosis (CME) is a systemic disease prevalent in the entire world caused by the obligate intracellular bacteria Ehrlichia canis . The occurrence of myocarditis with a high prevalence of arrhythmias in dogs affected by this disease in the cytopenic phase has already been proven. This study aims to evaluate the concentrations of CK MB, cTnI and NT-proBNP in dogs affected by Ehrlichia canis in the chronic phase since the intense stimulation of the immune system can lead to myocarditis; to evaluate if the condition can lead to arrhythmic events and, if so, define their frequency and classification through conventional and ambulatory electrocardiogram tests (Holter method) for a period of 24 hours; to analyze heart rate variability in the time domain and whether the condition can lead to autonomic imbalance; and to determine the survival rate of affected dogs, identifying possible risk factors for mortality at this stage of the disease. For this purposes, we evaluated clinical, hematological and biochemical data, as well as the concentrations of cardiac biomarkers Creatine Kinase-MB (CK MB), Cardiac Troponin I (cTnI) and N-terminal pro-peptide natriuretic type B (NT-proBNP). We also analyzed conventional and ambulatory electrocardiography (24-hour Holter) and heart rate variability (HRV) in 20 dogs afflicted by cytopenic CME in the chronic phase of the disease (G1) and compared the results with a control group comprised of ten healthy dogs (G2). G1 was monitored during the treatment for 28 days, during which eight (8) of the 20 infected dogs died (40%). Anorexia, vomiting, fatigue, hypoalbuminemia, heart murmurs and increased concentrations of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were common clinical signs. The mean concentrations of cTnI and CKMB were significant (0.24 ng / mL ± 0.5, 229 ± 205 IU / mL) in comparison to the control group (0.042 ± 0.07 ng / mL, 126 ± 46.12 IU / mL). No significant differences were observed between NT-proBNP concentrations in G1 (135.46 ± 29.7) and G2 (138.28 ± 19.77). Nine of the twenty dogs (45%) presented a high frequency of arrhythmias during 24-hour recording, ranging from first and second-degree atrioventricular block, ventricular and supraventricular ectopic events and sinus tachycardia. No sinus pause was observed. One dog had 120 episodes of unsustained ventricular tachycardia and two episodes of sustained ventricular tachycardia. The short-term and long-term HRV data, represented by SDNN (ms), SDANN (ms) and pnn50 (%) were also significant lower (83 ± 65, 56.05 ± 37.3 and 14.56 ± 20, respectively) in comparison to the healthy animals (268 ± 74.6, 168.3 ± 39.14 and 55.87 ± 12.8, respectively). These results suggest that cytopenic CME is characterized by an arrhythmogenic component and intense stimulation of the sympathetic autonomic nervous system in the heart, reflecting an imbalance in the activity of the ANS.

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Association of myocardial parasitic load with cardiac biomarkers and other selected variables in 10 dogs with advanced Canine Leishmaniasis

et al. 2021

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Background: The association between myocardial parasitic load (MPL) and cardiac biomarkers in Canine Leishmaniasis (CanL) has not been studied. Methods: Dogs with advanced CanL were prospectively recruited and were included if they were euthanised. Prior to euthanasia these variables were assessed: hematocrit, globulin, creatinine, N‐terminal‐pro brain natriuretic peptide (NT‐proBNP), cardiac troponin I (cTnI), blood pressure, urine protein/creatinine ratio and echocardiographic parameters. A left ventricular (LV) sample was taken for histopathology and MPL evaluation by quantitative PCR. Correlation of MPL with all variables was analysed. Dogs with lower and higher histopathology scores were compared. Results: Ten dogs were included. NT‐proBNP was 6946 pmol/ (interquartile range [IQR] 3751–9268 pmol/L) and cTnI 4.56 ng/mL (IQR 0.46–13.1 ng/mL). In all dogs, echocardiography showed an increase in LV thickening, and histopathology revealed moderate to severe lympho‐plasmocytic myocarditis and/or myocardial cell degeneration. MPL was 215.53 parasites/gram (IQR 21.2–1372.63 parasites/gram). A strong correlation (p < 0.001; R = 0.90; R20.81) with cTnI was observed but correlation with any of the other variables or differences between the two histopathological scores, were not detected. Conclusions: MPL in dogs with advanced CanL shows variable but generally high levels. A strong association between MPL and cTnI was observed, which encourages the exploration of cTnI as a marker in CanL.

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Immunopathological Features of Canine Myocarditis Associated withLeishmania infantumInfection

Cited by 15 publications

References 31 publications

Interpretación de los hallazgos electrocardiográficos, ecocardiográficos y bioquímicos durante las diferentes etapas de la leishmaniasis visceral canina

Interpretación de los hallazgos electrocardiográficos, ecocardiográficos y bioquímicos durante las diferentes etapas de la leishmaniasis visceral canina

Evaluation of heart rate variability and behavior of electrocardiographic parameters in dogs affected by chronic Monocytic Ehrlichiosis

Association of myocardial parasitic load with cardiac biomarkers and other selected variables in 10 dogs with advanced Canine Leishmaniasis

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