Immunopathologie et Maladies Parasitaires

Benex, J; Gayral, P.

doi:10.1016/s0399-077x(79)80116-x

Cited by 1 publication

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As in man and laboratory animals, DEC is excreted mainly by the kidneys. The decreased renal clearance could be associated with renal impairments of immunologic origin, which are often seen in human filariasis (18). DEC is also active on adult worms (I).…”

Section: Discussionmentioning

confidence: 99%

Experimental filariasis ofDipetalonema dessetae inProechimys oris: 3. Effects of parasitism on the pharmacokinetics of diethylcarbamazine

Gayral

Pfaff-Dessales³

et al. 1983

European Journal of Drug Metabolism and Pharmacokinetics

View full text Add to dashboard Cite

The pharmacokinetic parameters of diethylcarbamazine were compared in the plasma and peritoneal fluid of 5 non-infected rodents. In the filarial animals, the absorption rate constant and the elimination rate constant were significantly increased. The peak plasma concentration was twofold higher in the infested rodents than the control animals, and this may account for the rapid action of diethylcarbamazine on blood-circulating microfilariae. The area under the curve was unchanged. Total clearance is slightly increased in filarial rodents. These data are explained by an important reduction of renal clearance combined with a moderate increase of extra renal clearance. High levels of diethylcarbamazine in peritoneal fluid, resulting from the excellent diffusion of the drug in filarial animals explains the activity on adult worms. But the parasitism does not affect the mechanism of distribution of the drug between plasma and peritoneal liquid.

show abstract

Section: Discussionmentioning

confidence: 99%