Immunopathology of Acute Kidney Injury in Severe Malaria

Katsoulis, Orestis; Georgiadou, Athina; Cunnington, Aubrey

doi:10.3389/fimmu.2021.651739

Cited by 37 publications

(35 citation statements)

References 59 publications

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“…In this process, the EG is likely eroded, promoting coagulation, leukocyte adhesion, and loss of endothelial barrier function that culminates in cerebral edema [119] , [120] , [121] . Acute kidney injury is also common with P. falciparum through microvascular occlusion, local inflammation, and EG erosion [122] , [123] , resulting in filtration and tubular absorption defects [124] .…”

Section: The Endothelial Glycocalyx In Specific Pediatric Critical Il...mentioning

confidence: 99%

The endothelial glycocalyx in critical illness: A pediatric perspective

Richter

Payne²,

Ambalavanan³

et al. 2022

Matrix Biology Plus

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Section: The Endothelial Glycocalyx In Specific Pediatric Critical Il...mentioning

confidence: 99%

The endothelial glycocalyx in critical illness: A pediatric perspective

Richter

Payne²,

Ambalavanan³

et al. 2022

Matrix Biology Plus

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“…Previously, it has been proposed that parasite sequestration in the kidney may play a role in the pathogenesis of AKI in malaria ( Katsoulis et al., 2021 ). In post-mortem studies, sequestration of P. falciparum parasites was higher in glomerular and peritubular capillaries of patients with AKI compared to malaria patients without AKI ( Nguansangiam et al., 2007 ).…”

Section: Discussionmentioning

confidence: 99%

“…Parasite sequestration, which is the binding of infected red blood cells (iRBCs) to endothelial cells (ECs), has been proposed as a potential contributor to AKI pathogenesis in malaria ( Katsoulis et al., 2021 ). Post-mortem studies observed parasite sequestration of P. falciparum in glomerular and peritubular capillaries in adults and children with MAKI ( Nguansangiam et al., 2007 ; Milner et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Experimental malaria-associated acute kidney injury is independent of parasite sequestration and resolves upon antimalarial treatment

Possemiers

Pollenus²,

Prenen³

et al. 2022

Front. Cell. Infect. Microbiol.

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Malaria remains a important global disease with more than 200 million cases and 600 000 deaths each year. Malaria-associated acute kidney injury (MAKI) may occur in up to 40% of patients with severe malaria and is associated with increased mortality. Histopathological characteristics of AKI in malaria are acute tubular injury, interstitial nephritis, focal segmental glomerulosclerosis, collapsing glomerulopathy and glomerulonephritis. We observed that C57BL/6 mice infected with Plasmodium berghei NK65 (PbNK65) develop MAKI in parallel with malaria-associated acute respiratory distress syndrome (MA-ARDS). MAKI pathology was associated with proteinuria, acute tubular injury and collapse of glomerular capillary tufts, which resolved rapidly after treatment with antimalarial drugs. Importantly, parasite sequestration was not detected in the kidneys in this model. Furthermore, with the use of skeleton binding protein-1 (SBP-1) KO PbNK65 parasites, we found that parasite sequestration in other organs and its subsequent high parasite load are not required for the development of experimental MAKI. Similar proteinuria, histopathological features, and increases in kidney expression of interferon-γ, TNF-α, kidney injury molecule-1 (KIM-1) and heme oxygenase-1 (HO-1) was observed in both infected groups despite a significant difference in parasite load. Taken together, we introduce a model of experimental AKI in malaria with important similarities to AKI in malaria patients. Therefore, this mouse model might be important to further study the pathogenesis of AKI in malaria.

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“…Despite multiple Plasmodium species being reported to lead to kidney pathology, the relationship between kidney immune complex deposition and kidney pathology has only been reported in P. malariae malaria (29). This suggest that other non-autoantibody immune factors are needed in addition to promote kidney pathology in other human malarias underscoring the complexity of this phenomena (30). Lastly, there have also been several studies reporting autoantibodies against brain-associated antigens in patients suffering from P. falciparum cerebral malaria, but their pathogenic relevance remains to be determined (25).…”

Section: Pathological Role Of Autoantibodies During Malarial Anemia A...mentioning

confidence: 99%

Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections

Rivera-Correa

Rodrı́guez

2022

Front. Immunol.

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Autoimmunity is a common phenomenon reported in many globally relevant infections, including malaria and COVID-19. These and other highly inflammatory diseases have been associated with the presence of autoantibodies. The role that these autoantibodies play during infection has been an emerging topic of interest. The vast numbers of studies reporting a range of autoantibodies targeting cellular antigens, such as dsDNA and lipids, but also immune molecules, such as cytokines, during malaria, COVID-19 and other infections, underscore the importance that autoimmunity can play during infection. During both malaria and COVID-19, the presence of autoantibodies has been correlated with associated pathologies such as malarial anemia and severe COVID-19. Additionally, high levels of Atypical/Autoimmune B cells (ABCs and atypical B cells) have been observed in both diseases. The growing literature of autoimmune B cells, age-associated B cells and atypical B cells in Systemic Lupus erythematosus (SLE) and other autoimmune disorders has identified recent mechanistic and cellular targets that could explain the development of autoantibodies during infection. These new findings establish a link between immune responses during infection and autoimmune disorders, highlighting shared mechanistic insights. In this review, we focus on the recent evidence of autoantibody generation during malaria and other infectious diseases and their potential pathological role, exploring possible mechanisms that may explain the development of autoimmunity during infections.

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Immunopathology of Acute Kidney Injury in Severe Malaria

Cited by 37 publications

References 59 publications

The endothelial glycocalyx in critical illness: A pediatric perspective

The endothelial glycocalyx in critical illness: A pediatric perspective

Experimental malaria-associated acute kidney injury is independent of parasite sequestration and resolves upon antimalarial treatment

Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections

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