2005
DOI: 10.1590/s0074-02762005000900032
|View full text |Cite
|
Sign up to set email alerts
|

Immunopathology of giardiasis: the role of lymphocytes in intestinal epithelial injury and malfunction

Abstract: T lymphocyte-mediated pathogenesis is common to a variety of enteropathies, including giardiasis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
4
0

Year Published

2006
2006
2022
2022

Publication Types

Select...
7
2
1

Relationship

0
10

Authors

Journals

citations
Cited by 12 publications
(6 citation statements)
references
References 49 publications
2
4
0
Order By: Relevance
“…However, on the 15 th dPI, improvement in villous architecture was noticed with clearance of Giardia trophozoites. This was in accordance with Buret [50], who detected also increased intestinal disacharidase activity and decreased intraepithelial lymphocytes. Buret [51] also added that shortening of the microvilli could aggravate the deficiency in enzymatic and absorptive capability of enterocytes.…”
Section: Discussionsupporting
confidence: 92%
“…However, on the 15 th dPI, improvement in villous architecture was noticed with clearance of Giardia trophozoites. This was in accordance with Buret [50], who detected also increased intestinal disacharidase activity and decreased intraepithelial lymphocytes. Buret [51] also added that shortening of the microvilli could aggravate the deficiency in enzymatic and absorptive capability of enterocytes.…”
Section: Discussionsupporting
confidence: 92%
“…IFN-γ stimulates the production of high levels of nitric oxide and frequently acts in concert with other cytokines, such as TNF-α (Nacy et al, 1991). The results of the histopathological examination of the intestinal mucosa of the infected non-treated group are in agreement with multiple studies (Buret, 2005;Abdel-Fattah and Nada, 2007;Abdalla et al, 2011;Fathy, 2011;Mahmoud et al, 2014;Ismail et al, 2017). Numerous host factors, in addition to the interaction between trophozoites and the intestinal epithelium, were responsible for the microvillus changes and epithelial barrier dysfunction observed in the case of giardiasis (Scott et al, 2000;Chin et al, 2002).…”
Section: Introductionsupporting
confidence: 85%
“…The mechanisms responsible for diarrhea in giardiasis are less well understood: no toxins have been clearly identified, and the diarrhea results from malabsorption, not secretion (3,9,11). Enteric infections typically affect intestinal motility patterns by altering neuronal reflex pathways and smooth muscle responses to stimulation (2,23).…”
Section: Discussionmentioning
confidence: 99%