Immunopathology of human inflammatory bowel disease

Subclinical Intestinal Inflammation in Siblings of Children with Crohn’s Disease

“…Although the pathogenesis of CD is not yet clearly defined, CD most probably results from an inappropriate response of the mucosal immune system to the normal enteric flora in a genetically susceptible individual. Activation of innate immune responses, such as to local intestinal flora, is an important component of the initiation and propagation of inflammation in CD [1,2].…”

Possible involvement of the interleukin-15 and interleukin-15 receptor system in a heightened state of lamina propria B cell activation and differentiation in patients with inflammatory bowel disease

“…3 Increased numbers of immunoglobulin G (IgG) plasma cells have also been shown to be scattered in the inflamed areas, with positive correlations with the degree of histological inflammation, which is in parallel with the observation that cultures of isolated LPMCs from such areas synthesize and secrete IgG to a much greater degree than do the cells from control mucosa. [28][29][30][31][32] Although these phenomena have been thought to represent a general response to a variety of inflammatory stimuli, including immunoregulatory cytokines, it is largely unknown whether IL-15 could contribute to a heightened state of B-cell activation and differentiation in intestinal mucosa with IBD. We therefore evaluated the mucosal expression of IL-15 and its specific α-chain receptor, IL-15Rα, in the inflamed colonic tissues of patients with IBD.…”

Oxidative Stress and Pathogenesis of Inflammatory Bowel Disease: An Epiphenomenon or the Cause?

“…It is generally hypothesized that IBD is caused by gastrointestinal tract immune dysregulation, because the disease is accompanied by a considerable infiltration of inflammatory cells in gut mucosa [1].…”