Immunopathology of natural infection with Trypanosoma cruzi in dogs

Cruz-Chan, Julio Vladimir; Bolio-González, Manuel Emilio; Colin-Flores, Rafael Francisco; Ramírez-Sierra, María Jesús; Quijano-Hernández, Israel Alejandro; Dumonteil, Eric

doi:10.1016/j.vetpar.2009.02.024

Cited by 33 publications

(32 citation statements)

References 28 publications

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“…Similar to humans, dogs can develop acute and chronic phases of Chagas disease, and thus can serve as a good experimental model to study the pathogenesis of Chagas disease (Andrade et al, 1997;Barbabosa-Pliego et al, 2009;Cruz-Chan et al, 2009). Although uncommon, acute fatal Chagas disease cases have been described in dogs from this area of Panama (Samudio et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of trypanosome infections in dogs from Chagas disease endemic regions in Panama, Central America

Pineda

Saldaña

Monfante

et al. 2011

Veterinary Parasitology

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Section: Discussionmentioning

confidence: 99%

Prevalence of trypanosome infections in dogs from Chagas disease endemic regions in Panama, Central America

Pineda

Saldaña

Monfante

et al. 2011

Veterinary Parasitology

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“…Electrocardiographic surveys of infected dogs from endemic rural areas evidenced either a very low frequency of abnormalities or unspecific ones (Lauricella et al, 1989;Ruiz et al, 1985) or significant cardiac alterations (Cruz-Chan et al, 2009). Numerous fatal cases of young dogs (mainly pure-bred) were recorded in veterinary clinics from southern USA (Barr, 2009;Kjos et al, 2008;Williams et al, 1977).…”

Section: Course Of Infectionmentioning

confidence: 99%

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

2015

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“…In seropositive dogs, high IgG1 and high IgG2 levels have been associated with myocarditis, suggesting that a humoral immune response may lead to an increasing severity of the disease (80). The development of chronic chagasic cardiomyopathy in dogs correlates with high levels of IFN-␥ and TNF-␣ and low levels of IL-10 production (161).…”

Section: Autoimmunitymentioning

confidence: 99%

Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

et al. 2011

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SUMMARY Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast DNA (kDNA) minicircle to the genome of chagasic patients can explain the pathogenesis of the disease; in cases of Chagas' disease with evident cardiomyopathy, the kDNA minicircles integrate mainly into retrotransposons at several chromosomes, but the minicircles are also detected in coding regions of genes that regulate cell growth, differentiation, and immune responses. An accurate evaluation of the role played by the genotype alterations in the autoimmune rejection of self-tissues in Chagas' disease is achieved with the cross-kingdom chicken model system, which is refractory to T. cruzi infections. The inoculation of T. cruzi into embryonated eggs prior to incubation generates parasite-free chicks, which retain the kDNA minicircle sequence mainly in the macrochromosome coding genes. Crossbreeding transfers the kDNA mutations to the chicken progeny. The kDNA-mutated chickens develop severe cardiomyopathy in adult life and die of heart failure. The phenotyping of the lesions revealed that cytotoxic CD45, CD8 + γδ, and CD8α + T lymphocytes carry out the rejection of the chicken heart. These results suggest that the inflammatory cardiomyopathy of Chagas' disease is a genetically driven autoimmune disease.

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Immunopathology of natural infection with Trypanosoma cruzi in dogs

Cited by 33 publications

References 28 publications

Prevalence of trypanosome infections in dogs from Chagas disease endemic regions in Panama, Central America

Prevalence of trypanosome infections in dogs from Chagas disease endemic regions in Panama, Central America

Reservoir host competence and the role of domestic and commensal hosts in the transmission of Trypanosoma cruzi

Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity

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