Immunopathology of respiratory infections

Labro, M. T.

doi:10.1111/j.1469-0691.1998.tb00689.x

Cited by 1 publication

(1 citation statement)

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“…Igs play a major role in the protection of the lung against infection, with specific roles for different isotypes ( 15 ). Different Ig isotypes are dominant in different parts of the lung in the airways: the respiratory surface in the upper and lower airways is covered predominantly with secretory IgA (sIgA) and IgM, while in the alveolar space, IgG is the dominant isotype ( 16 , 17 ).…”

Section: Immunity and Immunodeficiency Of The Respiratory Systemmentioning

confidence: 99%

The Lung in Primary Immunodeficiencies: New Concepts in Infection and Inflammation

et al. 2018

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Immunoglobulin replacement therapy (IGRT) has contributed critically to the management of primary antibody deficiencies (PAD) and the decrease in pneumonia rate. However, despite adequate IGRT and improved prognosis, patients with PAD continue to experience recurrent respiratory tract infections, leading to bronchiectasis and continuing decline in lung function with a severe impact on their quality of life. Moreover, non-infectious inflammatory and interstitial lung complications, such as granulomatous-lymphocytic interstitial lung disease, contribute substantially to the overall morbidity of PAD. These conditions develop much more often than appreciated and represent a major therapeutic challenge. Therefore, a regular assessment of the structural and functional condition of the lung and the upper airways with appropriate treatment is required to minimize the deterioration of lung function. This work summarizes the knowledge on lung complications in PAD and discusses the currently available diagnostic tools and treatment options.

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Section: Immunity and Immunodeficiency Of The Respiratory Systemmentioning

confidence: 99%