Immunopharmacological intervention for successful neural stem cell therapy: New perspectives in CNS neurogenesis and repair

Dooley, Dearbhaile; Vidal, Pía M.; Hendrix, Sven

doi:10.1016/j.pharmthera.2013.08.001

Cited by 64 publications

(63 citation statements)

References 141 publications

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“…Damaged tissue and microenvironment affected stem cells survival, migration, and differentiation [55,56]. Hypoxic preconditioning was one of effective approaches to enhance stem cell survival in ischemic environment.…”

Section: Strategies To Enhance Survival Of Transplanted Stem Cellsmentioning

confidence: 99%

Opportunities and Challenges: Stem Cell‐Based Therapy for the Treatment of Ischemic Stroke

Tang

Zhang

et al. 2015

CNS Neurosci Ther

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Stem cell-based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell-based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell-based therapy is still in its infancy. The next decade of stem cell research in stroke field needs to focus on combining different stem cells and different imaging modalities to fully explore the potential of this therapeutic avenue: from bench to bedside and vice versa.

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Section: Strategies To Enhance Survival Of Transplanted Stem Cellsmentioning

confidence: 99%

Opportunities and Challenges: Stem Cell‐Based Therapy for the Treatment of Ischemic Stroke

Tang

Zhang

et al. 2015

CNS Neurosci Ther

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“…Despite these observations, the dual role of the neuroinflammatory response following CNS injury makes stem cell-supported regeneration difficult due to the presence of inhibitory immune factors that are upregulated in and around the lesion site. Therefore, modulating the inflammatory milieu by upregulating anti-inflammatory cytokines may be crucial when designing therapies for CNS repair (Dooley et al., 2013). With this in mind, using mesenchymal stem cells (MSCs) as an immune-modulating cellular therapy may exert positive effects in rodent models of spinal cord injury (SCI) (Alexanian et al., 2011, Nakajima et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

et al. 2016

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SummaryThe therapeutic effects of mesenchymal stem cell (MSC) transplantation following spinal cord injury (SCI) to date have been limited. Therefore, we aimed to enhance the immunomodulatory properties of MSCs via continuous secretion of the anti-inflammatory cytokine interleukin-13 (IL-13). By using MSCs as carriers of IL-13 (MSC/IL-13), we investigated their therapeutic potential, compared with non-engineered MSCs, in a mouse model of SCI. We show that transplanted MSC/IL-13 significantly improve functional recovery following SCI, and also decrease lesion size and demyelinated area by more than 40%. Further histological analyses in CX3CR1EGFP/+ CCR2RFP/+ transgenic mice indicated that MSC/IL-13 significantly decrease the number of resident microglia and increase the number of alternatively activated macrophages. In addition, the number of macrophage-axon contacts in MSC/IL-13-treated mice was decreased by 50%, suggesting a reduction in axonal dieback. Our data provide evidence that transplantation of MSC/IL-13 leads to improved functional and histopathological recovery in a mouse model of SCI.

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“…Similarly, Dearbhaile Dooley (Hendrix lab, Hasselt University, Belgium) has transplanted MSCs, virally transduced to express the TH2 anti-inflammatory cytokine interleukin 13, rostral to a spinal lesion site in the mouse. Dooley observed a reduction in lesion size and demyelination, potentially mediated by a decrease in the number of microglia/macrophages and increased T-cell numbers in the lesion (Dooley et al, 2014).…”

Section: Bench-to-bedside In Spinal Cord Injury and Pathologymentioning

confidence: 98%

Neural development and regeneration: it's all in your spinal cord

Becker

Corral

2015

Development

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The spinal cord constitutes an excellent model system for studying development and regeneration of a functional nervous system, from specification of its precursors to circuit formation. The latest advances in the field of spinal cord development and its regeneration following damage were discussed at a recent EMBO workshop 'Spinal cord development and regeneration' in Sitges, Spain (October, 2014), highlighting the use of direct visualization of cellular processes, genome-wide molecular techniques and the development of methods for directed stem cell differentiation and regeneration.

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Immunopharmacological intervention for successful neural stem cell therapy: New perspectives in CNS neurogenesis and repair

Cited by 64 publications

References 141 publications

Opportunities and Challenges: Stem Cell‐Based Therapy for the Treatment of Ischemic Stroke

Opportunities and Challenges: Stem Cell‐Based Therapy for the Treatment of Ischemic Stroke

Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

Neural development and regeneration: it's all in your spinal cord

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