Immunopharmacological properties of noopept

Коваленко, Л. П.; Shipaeva, Elena; Алексеева, С. В.; Пронин, А В; Дурнев, А. Д.; Gudasheva, T. A.; Ostrovskaja, R.U.; Середенин, С. Б.

doi:10.1007/s10517-007-0251-3

Cited by 4 publications

(10 citation statements)

References 5 publications

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“…Similar changes were described previously [1,5]. For example, the dipeptide Noopept (N-phenyl-acetyl-L-propyl-glycine, peptide analogue of piracetam) exhibits nootropic, neuroprotective, and anxiolytic properties [1].…”

Section: Group Of Micesupporting

confidence: 70%

“…The cellular immune response was estimated from delayed-type hypersensitivity reaction (DTH) of F 1 (CBA×C57Bl/6) mice [11]. Secondary immunodeficiency was induced by intraperitoneal injection of an alkylating agent CPA (Sigma) in a dose of 150 mg/kg [5]. GBA-115 was administered 3 times.…”

Section: Methodsmentioning

confidence: 99%

“…This compound increases phagocytic activity of peritoneal macrophages and stimulates the humoral and cellular immune response in mice of various strains during antigenic stimulation. Noopept was effective during secondary immunodeficiency due to CPA administration [5]. Some peptide preparations (delta sleep-inducing peptide, Cerebrolysin, and Noopept) significantly stimulate proliferative activity of various cells, including splenocytes (Noopept) and neurons (Cerebrolysin).…”

Section: Group Of Micementioning

confidence: 99%

“…GB-115 in doses of 0.1-10 mg/kg stimulated phagocytic activity of peritoneal macrophages and humoral immune response in intact mice. GB-115 exhibited immunocorrecting activity in animals with secondary immunodeficiency.Oligopeptides involved in homeostatic regulation of the nervous, endocrine, and immune system have a wide range of functions and exhibit anxiolytic, neuroprotective, antiulcer, antithrombotic, immunocorrecting, and other properties [2,5,9,10]. Peptide preparations are effective in low doses and have insignificant toxic activity [9].…”

mentioning

confidence: 99%

“…Oligopeptides involved in homeostatic regulation of the nervous, endocrine, and immune system have a wide range of functions and exhibit anxiolytic, neuroprotective, antiulcer, antithrombotic, immunocorrecting, and other properties [2,5,9,10]. Peptide preparations are effective in low doses and have insignificant toxic activity [9].…”

mentioning

confidence: 99%

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Immunocorrecting properties of GB-115 dipeptide

et al. 2008

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We studied the effects of a new dipeptide with anxiolytic activity (GB-115, N-phenylhexanoyl-glycyl-L-tryptophan amide) on parameters of the immune in intact mice and in animals with secondary immunodeficiency caused by cyclophosphamide. GB-115 in doses of 0.1-10 mg/kg stimulated phagocytic activity of peritoneal macrophages and humoral immune response in intact mice. GB-115 exhibited immunocorrecting activity in animals with secondary immunodeficiency.

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Section: Group Of Micesupporting

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Section: Group Of Micementioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Immunocorrecting properties of GB-115 dipeptide

et al. 2008

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Study of Anti-Inflammatory Effects of GB-115, a Glycine-Containing Retropeptide Cholecystokinin Analog

et al. 2011

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Anti-inflammatory effects of GB-115 compound (N-phenylhexanoyl-glycyl-L-tryptophan amide) injected intraperitoneally in doses of 0.1, 1, and 10 mg/kg were demonstrated on the model of ConA- and carrageenan-induced inflammation. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg to C57Bl/6 female mice with experimental autoimmune encephalomyelitis significantly alleviated the pathological symptoms, improved spontaneous locomotor activity, promoted recovery of thymus weight, and reduced edema and neutrophil infiltration of the perivascular space of the brain tissue. Intraperitoneal injection of GB-115 in a dose of 1 mg/kg suppressed generation of active oxygen forms by neutrophils in the chemiluminescence test.

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Nootropic dipeptide, Noopept can modulate hyperalgesia by effecting on spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression and apoptosis during persistent inflammation

Taghizadeh

Maghsoudi

Manaheji

et al. 2020

Preprint

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Background: There are largely unknown associations between changes in pain behavior responses during persistent peripheral inflammation and spinal cell alteration such as apoptosis. Some evidence suggests that microglia and microglia related mediators play notable roles in induction and maintenance of central nervous system pathologies and inflammatory pain. By considering those relationships and microglia related nootrophic factors, such as the Brain Derived Neurotrophic Factor (BDNF) in CNS, we attempted to assess the relationship between microglia dependent BDNF and its precursor with pain behavior through spinal cell apoptosis as well as the effect of Noopept on this relationship. Methods: Persistent peripheral inflammation was induced by a single subcutaneous injection of Complete Freund’s Adjuvant (CFA) on day 0. Thermal hyperalgesia, paw edema, microglial activity, microglia dependent BDNF, pro-BDNF expression, and apoptosis were assessed in different experimental groups by confirmed behavioral and molecular methods on days 0, 7, and 21 of the study. Results: Our findings revealed hyperalgesia and spinal cell apoptosis significantly increased during the acute phase of CFA-induced inflammation but was then followed by a decrement in the chronic phase of the study. Aligned with these variations in spinal microglial activity, microglia dependent BDNF significantly increased during the acute phase of CFA-induced inflammation. Our results also indicated that daily administration of Noopept (during 21 days of the study) not only caused a significant decrease in hyperalgesia and microglia dependent BDNF expression but also changed the apoptosis process in relation to microglia activity alteration. Conclusions: It appears that the administration of Noopept can decrease spinal cell apoptosis and hyperalgesia during CFA-induced inflammation due to its direct effects on microglial activity and microglia dependent BDNF and pro-BDNF expression.

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Immunopharmacological properties of noopept

Cited by 4 publications

References 5 publications

Immunocorrecting properties of GB-115 dipeptide

Immunocorrecting properties of GB-115 dipeptide

Study of Anti-Inflammatory Effects of GB-115, a Glycine-Containing Retropeptide Cholecystokinin Analog

Nootropic dipeptide, Noopept can modulate hyperalgesia by effecting on spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression and apoptosis during persistent inflammation

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