Immunopharmacology of Mast Cells

Church, Martin K.; Benyon, R. Christopher; Clegg, L. S.; Holgate, S T

doi:10.1007/978-3-642-73797-8_8

Cited by 7 publications

(5 citation statements)

References 139 publications

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“…The cross-linkage of immunoglobulin E (IgE) molecules and their high-affinity receptors by an allergen leads to degranulation and release of MC inflammatory mediators, such as histamine. Also, the neuropeptides substance P (SP), VIP and somatostatin (32)(33)(34), as well as the anaphylatoxins C3a and C5a of the complement system and a human neutrophil-derived histamine-releasing activity (HRA-N) (35), can release histamine from these cells. The release of MC mediators may also be a response to a change in ion concentration with edema (spongiosis) (36).…”

Section: The Mast Cellmentioning

confidence: 99%

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A theoretical model based upon mast cells and histamine to explain the recently proclaimed sensitivity to electric and/or magnetic fields in humans

Gangi

Johansson

2000

Medical Hypotheses

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Section: The Mast Cellmentioning

confidence: 99%

“…Ref. 32). Feder and Webb (76) showed in a study on rat basophilic leukemia (RBL) cells, a tumor MC line, that receptor motion and aggregation is induced by application of small (10 V/cm) static electric fields.…”

Section: Direct Effects Of Emfs On Mast Cellsmentioning

confidence: 99%

A theoretical model based upon mast cells and histamine to explain the recently proclaimed sensitivity to electric and/or magnetic fields in humans

Gangi

Johansson

2000

Medical Hypotheses

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“…Bridging of IgE molecules on the cell surface of mast cells and basophils initiates a cascade of biochemical events resulting in the release of histamine, arachidonic acid metabolites, and other proinflammatory mediators [1], It has recently been shown by different laboratories that immunological activation of both celi populations via the IgE receptor (FceRI) leads to changes in the intracel lular concentration of the multifunctional serine/threonine protein kinase, protein kinase C (PKC) [2][3][4][5][6][7][8]. Though the role of PKC is suggested to be pivotal for signal trans duction in many different cell types [9], its exact function in basophils and mast cells is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Studies on the Role of Protein Kinase C in Signal Transduction of Human Basophils

Amon

Stebut

Dietz

et al. 1992

Int Arch Allergy Immunol

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Recent investigations have demonstrated that activation of basophils involves the activation of protein kinase C (PKC). In the present study the effects of different nonselective and selective PKC inhibitors on IgE-mediated histamine release from human basophils were investigated. While potent but nonselective inhibitors such as staurosporine exerted a dose-dependent inhibition of Fc_ε-receptor-mediated histamine release, staurosporine derivatives with high selectivity for PKC potentiated the IgE-mediated response. The results provide evidence that the histamine release-inhibiting activity of protein kinase inhibitors is inversely correlated with their specificity for PKC. This may confirm the hypothesis that PKC exerts a negative modulatory role during the process of stimulus secretion-coupling following receptor aggregation in basophils. Moreover, investigations with phorbol esters and diacylglycerol derivatives as potent PKC activators show that direct cellular PKC activation and antigen-stimulated mediator release are not closely correlated.

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“…Mast cells may be activated to secrete their mediators by a wide variety of mechanisms, the most familiar being the IgE-dependent process. This involves the crosslinkage of high affinity IgE FcsRI receptor with activation ofthe phosphatidyl-inositol (PI) cycle, an influx of extracellular calcium ions and mobilization of intracellular calcium resulting in sequential granule exocytosis and the mobilization of arachidonic acid for oxidation into newly formed mediators [12]. Activation of mast cells at mucosal surfaces seems to be relatively restricted in being almost totally dependent on the IgE-triggered mechanism.…”

Section: Mast Cell Heterogeneitymentioning

confidence: 99%