Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content

Underwood, J. C. E.; Giri, DD; Rooney, N.; Lonsdale, Ray

doi:10.1038/bjc.1987.281

Cited by 8 publications

(3 citation statements)

References 11 publications

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“…Giorno (1983), Rowe and Beverly (1984), Bilik et al (1989) and others, although at odds with the findings of such groups as Horny and Horst (1986), Underwood et al (1987) (Edwards, 1985) Consistently greater numbers of CD4 + rather than CD8 + T cells bear this marker, whether in blood or in the tumour infiltrate. Tsudo et al (1986) and Robb et al (1987) have demonstrated that the 11-2 receptor has two components, one at 55 kDa, and the other, which carries the signal transduction mechanism, at 75 kDa (reviewed by Smith, 1989 qualitative, difference between the two cell types.…”

Section: Resultsmentioning

confidence: 56%

“…Studies utilising the ability of T cells to rosette sheep red blood cells showed that T cells were the major component of the lymphocytic infiltrate (Eremin et al, 1981;Vose et al, 1981;Eremin et al, 1982) (Whitwell et al, 1984;Gotlinger et al, 1985;Horny & Horst, 1986;Ben Ezra & Sheibani, 1987;Underwood et al, 1987;von Kleist et al, 1987;Zuk & Walker, 1987), others showed a predominance of CD8 + T cells (Giorno, 1983;Bhan & des Marais, 1983; Correspondence: A.M. Campbell. Received 22 March 1990; and in revised form 13 July 1990.…”

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confidence: 99%

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Flow cytometric analysis of tumour infiltrating lymphocytes in breast cancer

Whitford

Mallon²,

George³

et al. 1990

Br J Cancer

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Summary In 31 patients with carcinoma of the breast the phenotype and activation status of tumour infiltrating lymphocytes (TILs) was analysed by flow cytometry. The predominant cells, in all patients, were T lymphocytes and in the majority of cases CD8 + (cytotoxic/suppressor) T lymphocytes were present in greater numbers than CD4+ (helper) T lymphocytes. There was no relationship between the degree of lymphocytic infiltration and either tumour stage or grade but there appeared to be an inverse correlation with the levels of oestrogen receptor (ER) in the tumour (P<0.01). Both populations of T cells had significantly higher numbers of cells carrying HLA DR (class II major histocompatibility antigen) than the equivalent populations in peripheral blood from the same patient group (P<0.001). The transferrin receptor was found on similar numbers of CD8+ T cells in peripheral blood and among the tumour infiltrating lymphocytes while more of the CD4+ T cells infiltrating the tumour were found to carry this receptor (P=0.034). The Tac (CD25) antigen was also on similar numbers of CD8 + T cells from both peripheral blood and the tumour but was on fewer of the CD4+ T cells in the tumour with respect to peripheral blood (P = 0.029). In both TILs and blood lymphocytes, the Tac antigen was consistently present on greater numbers of CD4+ T lymphocytes than on the CD8+ T lymphocytes (P<0.001) and as this is a component of the interleukin 2 (IL-2) receptor this may be of relevance to the use of IL-2 in TIL cancer therapy.Tumour infiltrating lymphocytes (TILs) and in particular their response to interleukin 2 (IL-2), have attracted considerable interest in recent years because of their possible therapeutic potential (for reviews see Oldham et al., 1989;Rosenberg et al., 1989). It was first suggested by MacCarty (1922), on the basis of his observations on patients with gastric carcinoma, that lymphoid infiltration in breast tumours was a sign of host resistance. This appeared to be supported by the study of medullary carcinoma, which often has a marked lymphocytic infiltrate and has a particularly good prognosis (Moore & Foote, 1949). However, as Richardson (1956)

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Section: Resultsmentioning

confidence: 56%

mentioning

confidence: 99%

Flow cytometric analysis of tumour infiltrating lymphocytes in breast cancer

Whitford

Mallon²,

George³

et al. 1990

Br J Cancer

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“…NK cell activity is generally low or absent in the axillary lymph nodes of patients with demonstrable metastatic disease [12,13], although lymphokine-activated killer (LAK) precursor cells are often present [13]. There appears to be an inverse relationship between ER expression and NK activity [14,15]. ER-positive tumors have fewer T-cells when compared avith ER positive tumors [9].…”

Section: Immunosurveiilance Of Neoplastic Cells: Breast Cancermentioning

confidence: 99%

Human breast cancer cell line xenografts as models of breast cancer — The immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines

Clarke

1996

Breast Cancer Res Tr

107

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The ability to maintain and study human tissues in an in vivo environment has proved to be a valuable tool in breast cancer research for several decades. The most widely studied tissues have been xenografts of established human breast cancer cell lines into athymic nude mice. Human breast tumor xenografts provide the opportunity to study various important interactions between the tumor and host tissues, including endocrinologic, immunologic, and tumor-stroma interactions. The nude mouse is not the only immune-deficient recipient system in which to study xenografts. Additional single and combined mutant strains have been used successfully, including mice homozygous for the severe combined immune deficiency mutation (scid), both the beige (bg) and nude (nu) mutations in combination (bg/nu), and mice bearing the combined bg/nu/xid mutations. The differing immunobiologies are discussed, with particular reference to the immunobiology of breast cancer, as are the characteristics of several of the more frequently utilized breast cancer xenografts and cell lines. The ability of several endocrine treatments to modulate effectors of cell mediated immunity, e.g., estrogens and antiestrogens, and the effect of site of inoculation on tumor take and metastasis, also are described.

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Mechanisms of Resistance to Antiestrogens and Their Implications for Crossresistance

Clarke¹,

Lippman²

1996

Tamoxifen

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Immunophenotype of the lymphoid cell infiltrates in breast carcinomas of low oestrogen receptor content

Cited by 8 publications

References 11 publications

Flow cytometric analysis of tumour infiltrating lymphocytes in breast cancer

Flow cytometric analysis of tumour infiltrating lymphocytes in breast cancer

Human breast cancer cell line xenografts as models of breast cancer — The immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines

Mechanisms of Resistance to Antiestrogens and Their Implications for Crossresistance

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