Immunophenotypic characterization of acute leukemias in Bahia, Brazil

Santos, Mariane Melo dos; Santos, Allan de souza; Santos, Herbert Henrique de Melo; Santos, Lorene da Silva; Meyer, Roberto; Torres, Alex José Leite

doi:10.31744/einstein_journal/2023ao0117

Cited by 5 publications

(2 citation statements)

References 52 publications

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“…Overall, we observed the expression of CD13 in 21.8% of the B‐ALL patients, CD33 in 19.7% of the B‐ALL patients, and CD117 in 4.7% of the B‐ALL patients. The authors from high‐income and low‐income countries reported the aberrant expression of myeloid marker expression including 10.5%–54.5% CD13, 2.6%–89% CD33, and 0%–26.2% CD117 38,39,60,62–75 . These differences in frequencies of expression of various myeloid markers might be attributed to the inherent genetic differences among ethnic subpopulations, technical factors such as lack of uniformity in using monoclonal antibody clone type, and differences in flow cytometry methodology, processing, and data analysis 74,76 .…”

Section: Discussionmentioning

confidence: 99%

Hematological, clinical, immunophenotypic characterization, and treatment outcomes of prognostically significant genetic subtypes of B‐lineage acute lymphoblastic leukemia: A report of 1021 patients from India

Gupta

Varma

Sharma

et al. 2023

Cancer

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BackgroundThe published literature on hematological, clinical, flowcytometric‐immunophenotyping, and minimal residual disease outcomes of the prognostically important genetic subtypes of acute lymphoblastic leukemia (ALL) is scarce from low‐income countries. For newer classifications such as BCR::ABL1‐like ALLs, the scarcity of patient‐level data is even more pronounced.MethodsThe authors performed comprehensive detection of recurrent gene fusions and BCR::ABL1‐like ALL cases followed by immunophenotypic profiling and obtained clinical outcome parameters for a large cohort (n = 1021) of patients from India. This cohort included a significant number of patients with BCR::ABL1‐like ALL subtype and other genetic subtypes of ALL.ResultsPatients with BCR::ABL1‐positive and BCR::ABL1‐like ALL were significantly older, had male preponderance, and expressed a higher white blood cell count than BCR::ABL1‐negative cases (p < .05). Logistic regression modeling of B‐lineage‐ALL (B‐ALL) subtypes revealed that cluster of differentiation (CD)36 is a strong statistically significant predictive marker of BCR::ABL1‐like ALL (p < .05). Furthermore, patients with BCR::ABL1‐like ALLs show a significantly higher frequency of CD36 expression compared to BCR::ABL1‐negative ALLs (p < .05). In terms of clinical symptoms, lymphadenopathy is a strong statistically significant predictive marker in BCR::ABL1‐like ALLs compared to BCR::ABL1‐negative ALL cases (p < .05). In terms of treatment outcomes, minimal residual disease (MRD) positivity in BCR::ABL1‐positive ALL cases were statistically significant (p < .05), and BCR::ABL1‐like ALL cases had high MRD‐positivity as compared to BCR::ABL1‐negative ALL cases but did not show statistical significance.ConclusionsThe findings evince the use of novel therapies and personalized treatment regimens to improve the overall survival of the newer incorporated entities in B‐ALLs. This is the first report characterizing the hematological, clinical, flowcytometric‐immunophenotyping, and minimal residual disease outcomes of the prognostically significant subtypes of ALLs in patients from India.Plain Language Summary Characterizing the hematological, clinical, flowcytometric‐immunophenotyping, and minimal residual disease outcomes of the prognostically significant subtypes (n = 1021) of acute lymphoblastic leukemia (ALLs) in patients from India. We have made two independent logistic regression models of cluster of differentiation (CD) markers and clinical symptoms to differentiate prognostically significant subtypes of ALLs. Logistic regression analysis of CD markers revealed CD36 as a strong predictor in BCR::ABL1‐like ALL cases compared to BCR::ABL1‐negative ALL cases. Logistic regression analysis of clinical symptoms revealed lymphadenopathy significantly predicts BCR::ABL1‐like ALLs (p < .05). In terms of treatment outcomes, BCR::ABL1‐positive ALL had statistically significant minimal residual disease (MRD) (p < .05), and BCR::ABL1‐like ALL cases had high MRD‐positivity but did not show statistical significance as compared to BCR::ABL1‐negative ALLs.

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Section: Discussionmentioning

confidence: 99%

Hematological, clinical, immunophenotypic characterization, and treatment outcomes of prognostically significant genetic subtypes of B‐lineage acute lymphoblastic leukemia: A report of 1021 patients from India

Gupta

Varma

Sharma

et al. 2023

Cancer

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“…Posteriormente, um tremor de terra foi sentido, e desde então moradores dos bairros do Pinheiro, Bom Parto, Mutange e Bebedouro passaram a se defrontar com o surgimento danos estruturais nas ruas e imóveis. Visando esclarecer o fenômeno que acometia a região, um estudo geológico foi realizado e concluiu que o processo de afundamento do solo era decorrente as atividades de mineração para extração de sal-gema que vinha sendo realizada pela Braskem desde a década de 1970 (Ferreira;Bufrem, 2023;Nascimento;Sobrinho, 2022;Feitosa;Romeiro, 2023). No Brasil, a lei 14.750 de 2023 define desastre como a consequência de um incidente adverso, seja de natureza natural ou provocado por ação humana, que impacta negativamente ecossistemas e comunidades em situação de vulnerabilidade, resultando em danos substanciais tanto para a saúde humana quanto para os recursos materiais e o meio ambiente, acarretando prejuízos econômicos e sociais.…”

Section: Introductionunclassified

Perfil Epidemiologico Das Vítimas Da Instabilidade Do Solo Nos Bairros Afetados Pela Extração De Sal-Gema

dos Santos,

Alves,

Melo

et al. 2024

Atualizações Em Promoção Da Saúde

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Flow cytometric detection of leukemic blasts in Libyan pediatric patients with acute lymphoblastic leukemia

Elbnnani,

Elbasir,

Altabal

et al. 2024

Libyan Journal of Medicine

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The diagnosis of acute lymphoblastic leukemia (ALL), which is the most common type of cancer in children, has become more accurate with the use of flow cytometry. Here, this technology was used to immunophenotype leukemic cells in peripheral blood samples from Libyan pediatric ALL patients. We recruited 152 newly diagnosed patients at Tripoli Medical Center (Tripoli, Libya) by morphological examination of blood and bone marrow. Twenty-three surface and cytoplasmic antigen markers were used to characterize B and T cells in circulating blood cells by four-color flow cytometry. Six children (3.9%) turned out to have biphenotypic acute leukemia, 88 (57.9%) had B ALL, and 58 (38.1%) had T ALL. There were 68 cases of pro-B ALL CD10-positive (44.7%), 8 cases of pro-B ALL CD10-negative (5.2%), 6 cases of pre-B ALL (3.9%), and 6 of mature-B ALL (3.9%). CD13 was the most commonly expressed myeloid antigen in ALL. We present immunophenotypic data for the first time describing ALL cases in Libya. The reported results indicate that the most common subtype was pro-B ALL, and the frequency of T-ALL subtype was higher compared to previous studies. Six cases were positive for both myeloid and B lymphoid markers. Our findings may provide the basis for future studies to correlate immunophenotypic profile and genetic characteristics with treatment response among ALL patients.

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Immunophenotypic characterization of acute leukemias in Bahia, Brazil

Cited by 5 publications

References 52 publications

Hematological, clinical, immunophenotypic characterization, and treatment outcomes of prognostically significant genetic subtypes of B‐lineage acute lymphoblastic leukemia: A report of 1021 patients from India

Hematological, clinical, immunophenotypic characterization, and treatment outcomes of prognostically significant genetic subtypes of B‐lineage acute lymphoblastic leukemia: A report of 1021 patients from India

Perfil Epidemiologico Das Vítimas Da Instabilidade Do Solo Nos Bairros Afetados Pela Extração De Sal-Gema

Flow cytometric detection of leukemic blasts in Libyan pediatric patients with acute lymphoblastic leukemia

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