2022
DOI: 10.3390/cancers14235751
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Immunophenotyping of Circulating and Intratumoral Myeloid and T Cells in Glioblastoma Patients

Abstract: Glioblastoma is the most common and lethal primary brain malignancy that almost inevitably recurs as therapy-refractory cancer. While the success of immune checkpoint blockade (ICB) revealed the immense potential of immune-targeted therapies in several types of cancers outside the central nervous system, it failed to show objective responses in glioblastoma patients as of now. The ability of glioblastoma cells to drive multiple modes of T cell dysfunction while exhibiting low-quality neoepitopes, low-mutationa… Show more

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