Immunophenotyping of HPV Types 16 and 18 among Sudanese Patients with Oral Lesions

Ginawi, Ibrahim Abdelmageem Mohamed; Mahgoub, Ebtihag A.; Ahmed, Hussain Gadelkarim

doi:10.5001/omj.2012.45

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…The host immune responses such as proliferation of immune to respond to HPV16 were lower among women with persistent HPV infection in the oldest age group (>65 years) that seems to be determinants of incident infections decreased, whereas persistence of infection increased in older women . According to Ginawi et al found that the highest prevalence of HPV‐positive cases was in the age range 31‐50 years. Ahmed et al found the highest prevalence of HPV infection in 31‐ to 40‐year‐old individuals, followed by those in the 51‐ to 60‐year‐old group.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus in oral rinse samples from healthy individuals in northern Thailand

Bumrungthai

Ekalaksananan

Duangchai

et al. 2018

J Oral Pathology Medicine

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Background The incidence of oral cancers associated with human papillomavirus (HPV) has been increasing in recent years. Therefore, it is necessary to elucidate HPV prevalence in oral cells and exposure to risk factors in various age groups. Methods Oral rinse samples from healthy individuals in northern Thailand were investigated for HPV prevalence and genotyped using the polymerase chain reaction (GP5+/6+ primers) and DNA sequencing of the PCR products. Results Samples were collected from 594 participants between 4 and 60 years of age. HPV was detected in 3.7% of samples. The prevalence of HPV‐positive cases was 8.6% in the 31‐50 age group. HPV prevalence increased with age and was the highest (9.2%) in the 41‐50 age group, but decreased (to 3%) in the 51‐60 age group. Risk factors significantly associated with HPV‐positive cases included alcohol consumption, coffee drinking, sexual activity, and having children. HPV 16 and 18 were common genotypes, especially in the 31‐50 age group, and were associated with having sexual activity (odds ratio 19.0 [95% CI: 2.5‐142.5]). At follow‐up of some individuals in the 4‐10 age group, a 9‐year‐old child was found to be positive for HPV18. Conclusions These results suggest that HPV can be acquired at a young age and the prevalence peaks in the middle age class among healthy individuals in northern Thailand, especially in the 31‐50 age group.

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Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus in oral rinse samples from healthy individuals in northern Thailand

Bumrungthai

Ekalaksananan

Duangchai

et al. 2018

J Oral Pathology Medicine

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show abstract

“…Helicobacter pylori was found in 80% of patients with gastritis, 56% of patients with duodenal ulcer, 60% of patients with duodenitis and 16% of normal control subjects (Azim et al, 1994). The role of HPV, herpes simplex virus and Epstein-Barr virus in the etiology of oral cancers (Ahmed and Eltom, 2010;Jalouli et al, 2010), as well as the role of HPV in the development of cervical cancers cancer (Salih et al, 2010;Elasbali, et al, 2012;Ginawi et al, 2012) in different parts of Sudan was well established.…”

Section: Figure 2 Description Of the Study Subjects Answered (No) Inmentioning

confidence: 99%

Awareness Survey on Knowledge of Microbial Infectious Causes of Cancer in Northern State of Sudan

Ahmed

2012

Asian Pacific Journal of Cancer Prevention

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Objective: The aim of this study was to assess the level of cancer awareness after delivering educational programs by assessing the awareness in regard to the role of microbial infectious agents in the etiology of some cancers. Hussain Gadelkarim Ahmed places such as schools, clubs, mosques and Government health centre. A total of 21,415 participants benefited from these programs. Two hundred individuals were randomly selected for filling a form regarding the relationship between cancer and microbial infectious agent. During the programs, information was given about cancer, causes and prevention. During the program, pamphlets related to cancer were distributed among the participants to educate them about cancer.

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Human Papillomavirus–Associated Head and Neck Malignancies in Sub-Saharan Africa: A Systematic Review

Okerosi

Mokoh

Rubagumya

et al. 2023

JCO Global Oncology

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PURPOSE The proportion of head and neck cancers (HNCs) with human papillomavirus (HPV) positivity in sub-Saharan Africa (SSA) is poorly characterized. Characterizing this has implications in staging, prognosis, resource allocation, and vaccination policies. This study aims to determine the proportion of HPV-associated HNC in SSA. MATERIALS AND METHODS This systematic review included searches from PubMed, EMBASE, Web of Science, African Index Medicus, Google Scholar, and African Journals Online. All English publications reporting the proportion of HNC specimens from SSA patients who tested positive for HPV and/or p16 were included. Study quality was assessed using the National Institutes of Health Quality Assessment Tool for Case Series Studies. RESULTS In this systematic review of 31 studies and 3,850 patients, the overall p16 positivity was 13.6% (41 of 1,037 patients tested) with the highest proportion among oropharyngeal cancers (20.3%, 78 of 384 patients) and the overall HPV polymerase chain reaction positivity was 15.3% (542 of 3,548 samples tested) with the highest proportion among nasopharyngeal cancers (16.5%, 23 of 139 patients). Among the 369 HPV strains detected, the most common genotypes were HPV 16 (226 patients, 59.2%) and HPV 18 (78, 20.4%). CONCLUSION HPV was found to be associated with a significant proportion of HNC in SSA. The genotypes reported suggest that the nine-valent vaccine and gender-neutral vaccination policies should be considered. Given that these studies may not accurately capture prevalence nor causation of HPV in HNC subsites, additional research is needed to provide a more thorough epidemiologic understanding of HPV-associated HNC in SSA, including risk factors and clinical outcomes.

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Immunophenotyping of HPV Types 16 and 18 among Sudanese Patients with Oral Lesions

Abstract: The study suggests the role of HPV 16 and 18 in the etiology of oral cancers in different parts of Sudan. However, the use of molecular techniques such as PCR are needed to confirm the results of immunohistochemistry in the role of the HPV in developing of OSCC in Sudan.

Cited by 4 publications

References 33 publications

Prevalence of human papillomavirus in oral rinse samples from healthy individuals in northern Thailand

Prevalence of human papillomavirus in oral rinse samples from healthy individuals in northern Thailand

Awareness Survey on Knowledge of Microbial Infectious Causes of Cancer in Northern State of Sudan

Human Papillomavirus–Associated Head and Neck Malignancies in Sub-Saharan Africa: A Systematic Review

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