Immunopotentiating properties of extracellular polysaccharide from Trametes hirsuta strain VKESR

Shenbhagaraman, R.; Premalatha, M.; Jenefar, S.; Jagadish, L.; Saravanamurali, Krishnan; Kaveri, K; Karthik, Sankar Narayan; Kaviyarasan, V.

doi:10.1016/j.carbpol.2014.02.003

Cited by 9 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fructooligosaccharides of Asparagus recemosus with a polymerization degree of 7 to 8, a polysaccharide with a molecular mass of 47 kDa isolated from Litchi chinensis , polysaccharides from Trametes hirsuta and Pseudostellaria heterophylla , and ODNs from bacteria enhanced the cytotoxicity of NK cells. 32 , 39 - 42 Nigerooligosaccharides, which are enzymatically synthesized and mainly composed of nigerosyl maltose and nigerosyl glucose, had a stimulatory effect on NK cells. 43 Moreover, a synthetic heparin-type oligosaccharide that interacts with the natural cytotoxicity receptor NKp44, one of the activating receptors of NK, enhanced anti-NKp44-induced release of interferon-γ from an NKp44-expressing NK-92 cell line, indicating induction of NKp44-mediated NK activation.…”

Section: Discussionmentioning

confidence: 93%

Augmentation of Cytolytic Activity in Murine Natural Killer Cells and Inhibition of Tumor Growth by the Ethanol Fraction of Oyster Extract

et al. 2016

View full text Add to dashboard Cite

A reduced number and/or reduced activity of natural killer (NK) cells, which are important for defense against a variety of cancers and viral infections, occur under various stress conditions and in patients with various diseases. In this article, we report that the 30% to 50% ethanol precipitate of oyster extract (EPOE50) dose-dependently enhanced the activity of mouse spleen NK cells in vitro and in vivo. The activity of EPOE50 was eluted with a molecular weight of about 2000 by gel filtration and was inactivated by periodate but not by proteinase K. The activity of highly purified NK cells was also augmented by EPOE50 but not by oligodeoxyribonucleotide 1585, which mimics bacterial DNA. Administration of EPOE50 to mice stimulated splenic NK cell activity without a change in splenic NK cell populations. Although the proliferation of B16 tumor cells in vitro was slightly stimulated by EPOE50, the growth of B16 melanoma in vivo was dose-dependently suppressed by administration of EPOE50. Taken together, our results indicate that EPOE50 augmented NK cell activity and that its administration to mice inhibited tumor growth presumably through the activation of NK cells and also suggest that the active substance is a sugar-containing oligomer or polymer and is not of bacterial origin.

show abstract

Section: Discussionmentioning

confidence: 93%

Augmentation of Cytolytic Activity in Murine Natural Killer Cells and Inhibition of Tumor Growth by the Ethanol Fraction of Oyster Extract

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Grifola frondosa, Hericium erinaceum, Lentinus edodes, Penicillium jiangxiense, Pleurotus abalonus, Pleurotus ostreatus, Polyporus sp., Poria cocos, Inonotus sp., Schizophyllum communes, Trametes hirsuta, Trametes versicolor, Tremella sp. and Tricholoma aggregatum are among the recent studied mushrooms with astonishing anticancer effect, which is assigned to their polysaccharides (Chang 2007;Zong et al 2012;Shenbhagaraman et al 2014;Wang et al 2014).…”

Section: Mushrooms As a Major Source Of Anticancer Polysaccharidesmentioning

confidence: 99%

Carbohydrates Against Cancer

Saeidnia

2014

New Approaches to Natural Anticancer Drugs

View full text Add to dashboard Cite

Trametes betulina (L.) Pilát.; Trametes cinnabarina (Jacq.) Fr.; Trametes gibbosa (Pers.) Fr.; Trametes hirsuta (Wulfen) Lloyd; Trametes pubescens (Schumach.) Pilát; Trametes suaveolens (L.) Fr.; Trametes versicolor (L.) Lloyd - POLYPORACEAE

Gafforov,

Rašeta,

İnci

et al. 2023

Ethnobiology

View full text Add to dashboard Cite

Immunopotentiating properties of extracellular polysaccharide from Trametes hirsuta strain VKESR

Cited by 9 publications

References 38 publications

Augmentation of Cytolytic Activity in Murine Natural Killer Cells and Inhibition of Tumor Growth by the Ethanol Fraction of Oyster Extract

Augmentation of Cytolytic Activity in Murine Natural Killer Cells and Inhibition of Tumor Growth by the Ethanol Fraction of Oyster Extract

Carbohydrates Against Cancer

Trametes betulina (L.) Pilát.; Trametes cinnabarina (Jacq.) Fr.; Trametes gibbosa (Pers.) Fr.; Trametes hirsuta (Wulfen) Lloyd; Trametes pubescens (Schumach.) Pilát; Trametes suaveolens (L.) Fr.; Trametes versicolor (L.) Lloyd - POLYPORACEAE

Contact Info

Product

Resources

About