Immunoprofile of Hodgkin′s lymphoma in India

Abstract

AIMS AND BACKGROUND: The immunoprofi le of the Reed Sternberg cell with respect to immunoreactivity for CD20 and lack of CD15 has been described as a poor prognostic factor. Large scale studies analyzing the immunoprofi le of Hodgkin's lymphoma (HL) from India are lacking. The aim of this study was to obtain baseline information on relative frequencies and immunoprofi les of the two major types of HL and comparing reports from developed and developing countries. MATERIALS AND METHODS: 451 cases of HL were classifi ed as per the WHO into classical (n= 397) HL (cHL) and nodular lymphocyte predominant HL (NLPHL) (n=54). Cases of cHL were divided into 5 immunophenotypic groups; Group A (CD15+,CD30+,CD20-), Group B (CD15-,CD30+,CD20-), Group C (CD15+,CD30+,CD20+), Group D (CD15-,CD30+,CD20+)and Group E (CD15-,CD30-,CD20+). In cases of NLPHL, the immunophenotype of lymphocytes in the background, whether T(CD3) or B(CD20) rich was observed. RESULTS: Most cases of cHL belonged to Group A (44.58%) followed by Group B (40.05%), C(5.54%), D(9.57%) and E(0.25%). Half, (50.89%) the cases of cHL were immunonegative for CD15, whereas CD20 was expressed by 15.61% of the cases. Three (5.55%) cases of NLPHL showed a CD3 (T) cell rich background. Signifi cant differences were also observed with respect to the age distribution of cHL as compared to the west. CONCLUSION: Our study demonstrates that India has a high number of CD15 negative and a relatively higher number of CD20 positive cHL cases as compared to the western population. Favorable treatment response and good cure rates that one sees in western cHL may not apply to India.

Infrequent expression of CD15 by classical Hodgkin's lymphomas in Taiwan

“…Similar to our low frequency (43%) of CD15 expression in CHL, in a cohort of 397 cases of CHL from India, only 49% cases were immune-reactive for CD15 (from Dako, for non-sialylated form) 10. In a small series (33 cases) of CHL from Taiwan, Chang et al 11 reported that CD15 (Clone C3-D1, DAKO, for non-sialylated CD15) was expressed in 71% cases.…”

Malignant lymphoma in northern Iraq: A retrospective analysis of 270 cases according to the World Health Organization classification

“…This rate of 31 % is similar to the 30% seen in west [1] and appears to be within the range reported from surrounding Eastern Mediterranean countries as well as India where rates varied from 21.6% in Jordan to 41% in UAE. [18][19][20][21][22][23][24] These findings contrast with the much lower frequency in East Asian countries such as Japan where HL constitutes only 7% of ML in a recent large study. [4] The most frequent histological subtype of HL in the current study was NS, which is different from earlier reports from Iraq, [10,11] and some earlier reports from nearby countries and India, [6,19,[22][23][24][25] in which the mixed cellularity subtype was the most frequent.…”

“…[18][19][20][21][22][23][24] These findings contrast with the much lower frequency in East Asian countries such as Japan where HL constitutes only 7% of ML in a recent large study. [4] The most frequent histological subtype of HL in the current study was NS, which is different from earlier reports from Iraq, [10,11] and some earlier reports from nearby countries and India, [6,19,[22][23][24][25] in which the mixed cellularity subtype was the most frequent. This changing pattern is consistent with more recent reports from Saudi Arabia, Jordan, UAE and Kuwait, where higher relative rates of NS HL were reported approaching those seen in the United States and Europe.…”

Pattern of lymphoma subtypes in a cohort of Sri Lankan patients

“…Mixed cellular and nodular sclerosis types is the most common HL sub types in the reviewed countries. In the Sri Lankan sample, Pakistan and India the commonest HL sub type was mixed cellular, where as in the USA and Japan the commonest was nodular sclerosis type [5,8,9,10].…”