Immunoproliferative small intestinal disease: Mediterranean lymphoma and α heavy chain disease

Martin, Ian; Aldoori, M I

doi:10.1002/bjs.1800810107

Cited by 44 publications

(21 citation statements)

References 34 publications

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“…Like gastric MALT lymphoma, IPSID responds to antibiotic therapy. When treated in the early stage, up to 40% of tumors will completely regress with antibiotic treatment (typically tetracycline) (91)(92)(93). The precise reason for these remissions remains unclear.…”

Section: Environmental Health Perspectivesmentioning

confidence: 99%

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Bacterial infection as a cause of cancer.

Parsonnet

1995

Environ Health Perspect

161

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Bacterial infections traditionally have not been considered major causes of cancer. Recently, however, bacteria have been linked to cancer by two mechanisms: induction of chronic inflammation and production of carcinogenic bacterial metabolites. The most specific example of the inflammatory mechanism of carcinogenesis is Helicobacter pylori infection. H. pylori has been epidemiologically linked to adenocarcinoma of the distal stomach by its propensity to cause lifelong inflammation. This inflammation is in turn thought to cause cancer by inducing cell proliferation and production of mutagenic free radicals and N-nitroso compounds. H. pylori is the first bacterium to be termed a definite cause of cancer in humans by the International Agency for Research on Cancer. Mutagenic bacterial metabolites are also suspected to increase risk for cancer. This model is best exemplified in colon cancer. Bile salt metabolites increase colonic cell proliferation. Exogenous compounds such as rutin may be metabolized into mutagens by resident colonic flora. Moreover, Bacteroides species can produce fecapentaenes, potent in vitro mutagens, in relatively high concentrations. In vivo data on human carcinogenesis by bacterial metabolites, however, are inconsistent. Local bacterial infections may also predispose to nonnodal lymphomas, although the mechanisms for this are unknown. Gastric lymphomas and immunoproliferative small intestinal disease have been most strongly linked to underlying bacterial infection. Because bacterial infections can be cured with antibiotics, identification of bacterial causes of malignancy could have important implications for cancer prevention. -Environ Health Perspect 1 03(Suppl 8): 263-268 (1995)

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Section: Environmental Health Perspectivesmentioning

confidence: 99%

“…Commonly known as Mediterranean lymphoma, IPSID is a MALT-type lymphoma that is almost invariably associated with excessive production of a heavy chains (91). Like gastric MALT lymphoma, IPSID responds to antibiotic therapy.…”

Section: Environmental Health Perspectivesmentioning

confidence: 99%

Bacterial infection as a cause of cancer.

Parsonnet

1995

Environ Health Perspect

161

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“…Laborchemisch wegweisend sind in frühen Krankheitsstadien erhöhte IgAWerte im Serum, eine breite α 2 -und β-Region in der Immunelektrophorese, sowie bei 20-87% der Patienten das Vorkommen von α-Ketten in Speichel, intestinalen Sekreten oder im Urin (α-Paraproteinurie bei charakteristischerweise fehlenden Bence-Jones-Proteinen; [12]). Von diesem Krankheitsbild betroffen sind in erster Linie Patienten mit einem niedrigen sozioökonomischen Status, Lebensalter zwischen 20 und 40 und mit einer direkten Abstammung überwiegend aus Nordafrika, Israel, dem mittleren Osten,Mexiko oder aus Mittelmeerländern.…”

Section: Ipsid: Definition Klinische Stadien Und Epidemiologieunclassified

“…Der oder die antigenen Stimuli sind bisher unbekannt [5,7,12]. Eine Konversion zu einem hochmalignen Lymphom kann mit einem plötz-lichen Abfall des Serum IgA-Wertes als Zeichen einer Entdifferenzierung einhergehen,die Lymphommanifestationen bilden in der Regel abgrenzbare Tumormassen in unterschiedlichen Bereichen des Gastrointestinaltrakts, jedoch nach Literaturlage nur selten außerhalb des Abdomens [8,11].…”

Section: Ipsid: Definition Klinische Stadien Und Epidemiologieunclassified

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Malassimilationsyndrom

et al. 2004

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In a young female patient originally coming from Albany, immunoproliferative small intestinal disease (IPSID) could be diagnosed as a cause for severe maladsorption. Considering clinical and histological criteria an early disease stage of IPSID could be diagnosed. Under the continuous treatment of doxycycline for more than 3 1/2 years, all disease manifestations like watery diarrhea, vomiting, pain in the upper abdomen and loss of weight disappeared. After discontinuation of the antibiotic therapy the patient reached a sustained response.

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Five-year results of the treatment of 23 patients with immunoproliferative small intestinal disease

Akbulut

Soykan

Yakaryılmaz

et al. 1997

Cancer

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(1 g/day, orally) for a median duration of 7 months (range, 6-11 months) initially, whereas the remaining patients (9 Stage B patients and 7 Stage C patients) received 1 Department of Medical Oncology, Ibn-i Sina combination chemotherapy (cyclophosphamide, vincristine, procarbazine, and Hospital, Ankara University School of Medicine, prednisolone [COPP regimen]) followed by tetracycline at a dose of 1 g/day for 6 Sihhiye-Ankara, Turkey.more months in patients with complete response (CR) after the COPP regimen. 2 Department of Gastroenterology, Ibn-i Sina RESULTS. The median follow-up was 68 months (range, 38-89 months). As first-Hospital, Ankara University School of Medicine, line therapy in Stage A patients, tetracycline yielded a 71% CR and 43% disease Sihhiye-Ankara, Turkey.free survival (DFS) rate. Eleven of 16 patients (69%) with Stage B or C disease who 3 Department of Third Internal Medicine, SSK received the COPP regimen achieved CR and only 2 patients had a recurrence Hospital, Diskapi-Ankara, Turkey.(DFS rate of 56%). The 5-year overall survival (OAS) rate for the entire group was 70%, and the 5-year DFS rate for patients with CR was 75%. However, the median

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Immunoproliferative small intestinal disease: Mediterranean lymphoma and α heavy chain disease

Cited by 44 publications

References 34 publications

Bacterial infection as a cause of cancer.

Bacterial infection as a cause of cancer.

Malassimilationsyndrom

Five-year results of the treatment of 23 patients with immunoproliferative small intestinal disease

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