Immunoprophylaxis of infections of the upper respiratory tract in the frequently ill children

Ep, Karpova; Zaplatnikov, A.L.; Da, Tulupov

doi:10.17116/otorino201580580-84

Cited by 5 publications

(2 citation statements)

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“…1 in Svyatoshynskiy district, Kyiv. Inclusion criteria were as follows: aged between 3-10 years old, experiencing a high frequency of acute UR-TIs characterized by a resistance index above 0.33 (i.e., URTI episode occurring more often than once every 3 months) during the past year [28], and the absence of other medications or supplements with immunomodulatory properties in the treatment regimen. Children with chronic pathological conditions (e.g., diabetes, asthma, leukaemia, primary immunodeficiencies, HIV, hepatitis etc.)…”

Section: Methodsmentioning

confidence: 99%

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Prophylactic Effect of a Probiotic Intervention in Children Prone to Acute Upper Respiratory Tract Infections: A Randomized Controlled Trial

2021

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Relevance. Upper respiratory tract infections (URTIs) are common in children and often progress with secondary complications such as otitis media, bronchitis, or pneumonia, especially in children with recurrent URTIs. Probiotics displayed immunomodulatory effects in children and adults, supporting immune functions to prevent winter diseases or common colds. Objectives. We assessed the effectiveness of a 6-week prophylaxis with probiotics (Lactobacillus helveticus Rosell®-52, Bifidobacterium infantis Rosell®-33 and Bifidobacterium bifidum Rosell®-71) for preventing primary infections and/or secondary complications in URTI-prone children. Methods. URTI-prone children were randomly divided into the probiotics (3×109 CFU/day; 6 weeks) or control arm (no preventive intervention). The number of URTIs, duration and related complications were monitored for 6 months. Resistance index, number of medical visits, and antibiotics prescriptions were also recorded. Results. After 2 months, probiotics reduced the number of URTIs (-2.34±0.13 vs -0.24±0.14; P<0.0001) and duration in (-1.13 ±0.18 vs -0.18±0.18 days; P=0.0011), and the number of secondary complications (-53% vs -5.8%; RR 0.5313 95% CI [0.3534, 0.7986] P= 0.0058). Probiotic lowered resistance index (P<0.0001), number of medical consultations with specialized physicians (P=0.0033) and antibiotics prescriptions (P<0.0001). Conclusions. Overall, a 6-week prophylaxis with combined probiotic (Lactobacillus helveticus Rosell®-52, Bifidobacterium infantis Rosell®-33 and Bifidobacterium bifidum Rosell®-71) in URTI-prone children exerted a significant and clinically important health benefit, decreasing the number and duration of URTI episodes and secondary complications and reducing the resistance index to a near-normal value. Furthermore, potential societal benefits of reducing health care use and inadequate antibiotic prescriptions in children favours the use of this probiotic product as a preventive strategy against URTIs and their consequences in frequently sick children. This trial was retrospectively registered on ClinicalTrials.gov (NCT04525040).

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Section: Methodsmentioning

confidence: 99%

“…The nomogram method was used for the calculation of sample size. A total of 60 children were anticipated based on a mean clinically significant difference of 0.37 in the resistance index, with a power of 0.80 and alpha of 0.05 [28,29].…”

Section: Methodsmentioning

confidence: 99%

Prophylactic Effect of a Probiotic Intervention in Children Prone to Acute Upper Respiratory Tract Infections: A Randomized Controlled Trial

2021

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Efficiency of topical bacterial lysates in inflammatory diseases of the oral cavity and pharynx

Шахов

Krasilnikova

2023

Medicinskij sovet

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Acute and chronic infectious and inflammatory diseases of the upper respiratory tract occupy one of the leading places in the structure of morbidity of the population of the world and remain the most frequent cause of patients seeking medical care. The prevalence and frequency of respiratory infectious diseases make a significant contribution to the structure of the causes of temporary disability, which entails negative socio-economic consequences. Specific attention in the current epidemic season is attracted by the change in the traditional structure of pathogens associated with several strict anti-epidemic measures during the COVID-19 pandemic, as well as a decrease in the activity of other pathogens during the active circulation of SARS-CoV-2. In this aspect, the increased resistance of pathogens to etiotropic drugs and insufficiency of the arsenal of pathogenic drugs dictate the need to search for alternative approaches to the treatment of inflammatory diseases of the mouth and throat. The main purpose of non-specific preventive measures of acute and recurrent diseases of the oral cavity and pharynx is to reduce bacterial content of mucous membranes by various pathogens and to activate own protective anti-infective mechanisms. In clinical practice medicines which contain bacterial lysates are considered to be an effective part of treatment of upper respiratory tract’s inflammatory diseases. They allow achieving elimination of a pathogenic organism and also help to restore autoregulation of immune response in the whole organism, reduce the frequency of infectious diseases. Topical bacterial lysates, acting directly in the locus of inflammation, do not harm the human microbiome, have a high safety profile, combine well with other medicines and can be used for patients of different ages. Topical immunotherapy has a significant preventive effect, preventing possible complications and improving the quality of life. The use of Imudon and IRS 19 leads to positive clinical and immunological shifts and promotes the efficiency of rehabilitation and preventive measures.

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Еffectiveness of immunocorrective therapy for frequently ill children

Zakirova,

Krasnozhen,

Shayapova

et al. 2024

Medicinskij sovet

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Introduction. All acute respiratory infections are characterized by damage to the mucous membrane of the respiratory tract, a decrease in local immune defense and a weakening of nonspecific protective factors.Aim. To characterize the clinical effectiveness of the use of the immunocorrective drug in frequently ill children.Materials and methods. The article assessed the microbiological spectrum of the rhinopharyngeal landscape in 65 children: 33 children took an immunocorrective drug in addition to conventional therapy – the main group; 32 children received conventional therapy (the comparison group), and also investigated the possibility of regulating their polypathogenic microbiota using topical bacterial lysates.Results and discussion. The result of the therapy was a clinical improvement characterized by the relief of pharyngoscopic signs of chronic tonsillitis in children while taking topical bacterial lysates in form of lozenges. Analysis of the microbiota of the oropharyngeal mucosa in the studied patients of both groups before the start of therapy revealed the species diversity of opportunistic flora, among which Streptococcus pyogenes, Staphylococcus aureus, the family Enterobacteriaceae and Candida albicans were identified in all patients in diagnostic significant titers of 105–1010. After treatment in the main group, the ratio of the microbiota of the nasopharynx significantly changed, stimulation of the production of local immunity components was noted, which was confirmed by a decrease in the intensity of contamination of microbiota with polypathogenic functions to diagnostically insignificant titers. When comparing the species composition of the microbiota in the studied groups after treatment with topical bacterial lysates, a statistically significant positive effect was found without additional use of antibacterial drugs.Conclusions. It has been shown that the immunocorrective drug eliminates pharyngoscopic signs of rhinopharyngeal dysbiosis in children who are often and long-term ill.

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Immunoprophylaxis of infections of the upper respiratory tract in the frequently ill children

Cited by 5 publications

References 28 publications

Prophylactic Effect of a Probiotic Intervention in Children Prone to Acute Upper Respiratory Tract Infections: A Randomized Controlled Trial

Prophylactic Effect of a Probiotic Intervention in Children Prone to Acute Upper Respiratory Tract Infections: A Randomized Controlled Trial

Efficiency of topical bacterial lysates in inflammatory diseases of the oral cavity and pharynx

Еffectiveness of immunocorrective therapy for frequently ill children

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