Immunoreactions Involving Platelets. Vi. Reactions of Maternal Isoantibodies Responsible for Neonatal Purpura. Differentiation of a Second Platelet Antigen System*

Shulman, N. Raphael; Aster, Richard H.; Pearson, Howard A.; Hiller, Merilyn C.

doi:10.1172/jci104556

Cited by 85 publications

(34 citation statements)

References 20 publications

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“…Since it has been shown that platelets often carry the same isoantigens as leukocytes (8,13), the question will arise whether leukocyte group four has any connection with the platelet groups described so far (20)(21)(22)(23)(24). Although leukocyte group four substance is present on platelets as can be demonstrated by absorption experiments, leukocyte group four is not identical with one of the platelet groups, because the isoantigetis of these groups are not present on leukocytes, and furthermore their gene-frequencies are basically different from those of group four.…”

Section: Discussionmentioning

confidence: 99%

Leukocyte Grouping. A Method and Its Application*

Rood¹,

Leeuwen²

1963

J. Clin. Invest.

286

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Section: Discussionmentioning

confidence: 99%

Leukocyte Grouping. A Method and Its Application*

Rood¹,

Leeuwen²

1963

J. Clin. Invest.

286

View full text Add to dashboard Cite

“…Platelets also harbor MHC class I molecules both on their plasma membrane and intracellularly (66). On the platelet plasma membrane, MHC class I molecules are primarily adsorbed from plasma and generally consist of denatured H chains.…”

Section: Platelet Mhc Class Imentioning

confidence: 99%

Nouvelle Cuisine: Platelets Served with Inflammation

Kapur

Zufferey

Boilard

et al. 2015

The Journal of Immunology

179

191

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Platelets are small cellular fragments with the primary physiological role of maintaining hemostasis. In addition to this well-described classical function, it is becoming increasingly clear that platelets have an intimate connection with infection and inflammation. This stems from several platelet characteristics, including their ability to bind infectious agents and secrete many immunomodulatory cytokines and chemokines, as well as their expression of receptors for various immune effector and regulatory functions, such as TLRs, which allow them to sense pathogen-associated molecular patterns. Furthermore, platelets contain RNA that can be nascently translated under different environmental stresses, and they are able to release membrane microparticles that can transport inflammatory cargo to inflammatory cells. Interestingly, acute infections can also result in platelet breakdown and thrombocytopenia. This report highlights these relatively new aspects of platelets and, thus, their nonhemostatic nature in an inflammatory setting.

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“…A foetalis thrombocyta felszínén lévő alloantigének (human platelet antigen -HPA) által az anyában termelődő antitestek okozzák [15,16]. Bár általában nem okoz sú-lyos problémát, mégis az újszülöttkori morbiditás és mortalitás egyik igen jelentős oka.…”

Section: úJszülöttkori Alloimmun Thrombocytopeniaunclassified

Thrombocytopenia

Gadó

Domján

2014

Orvosi Hetilap

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Thrombocytopenia alatt a vérlemezkék számbeli csökkenését értjük. Ez a vérzékenység leggyakoribb oka. Klinikailag petechiák, purpurák megjelenése, nyálkahártyavérzés jellemzi. Előfordulhat azonban akár életet fenyegető, emésztő-rendszert vagy központi idegrendszert érintő vérzés is. A haemostaseologiai laboratóriumi vizsgálatok közül a megnyúlt vérzési idő utal thrombocytaeredetű vérzékenységre. Kialakulásában vagy a csontvelői csökkent megakaryopoesis, vagy a fokozott thrombocytapusztulás, illetve a kettő kombinációja játszik szerepet. Thrombocytopenia észlelésekor a teendő az ok tisztázása. Ebben a csontvelő és a perifériás vérkenet vizsgálata mellett a háttérben álló feltételezett alapbetegség célzott diagnosztikája lehet segítségünkre. A kezelés részint az alapbetegséget célozza, ré-szint a hiányzó komponens -a thrombocyta -pótlását jelenti. Utóbbi a thrombocyták aktiválódása és felhasználó-dása által előidézett kórképek esetén azonban szigorúan tilos, mivel a kórfolyamat progresszióját idézheti elő. Orv. Hetil., 2014, 155(8), 291-303. Kulcsszavak: thrombocytopenia, vérzékenység, csontvelő, immunthrombocytopenia, terhességi thrombocytopenia ThrombocytopeniaThrombocytopenia means low platelet count. This is the most frequent cause of bleeding abnormalities. Petechias, purpuras, mucosal bleeding are typical clinical fi ndings. Severe, even life threatening gastrointestinal or intracranial bleeding may also occur. Diagnostic laboratory fi nding is the prolonged bleeding time. There are several causes of thrombocytopenia. The major mechanisms for a reduced platelet count are decreased production and increased destruction of platelets, or both. The major task is to reveal the underlying cause. Examination of the bone marrow and the peripheral blood smear can be helpful as well as special diagnostics of the assumed disease. Therapy targets the underlying disease, and also involves platelet transfusion. However, in case of diseases with increased platelet activation and consumption, platelet transfusion is forbidden because it may lead to aggravation of the pathologic process.Keywords: platelet, bleeding disorders, bone marrow, immune-thrombocytopenia, gestation thrombocytopenia Gadó, K., Domján, Gy. [Thrombocytopenia]. Orv. Hetil., 2014, 155(8), 291-303. (Beérkezett: 2013 elfogadva: 2013. december 27.) Rövidítések aPTI = aktivált parciális tromboplasztin; DIC = disszeminált intravascularis coagulopathia; DITP = gyógyszer indukálta immunthrombocytopenia; FDA = Food and Drug Administration (USA); HIT = heparin indukálta thrombocytopenia; HPA = human platelet antigen; ITP = immunthrombocytopeniás purpura; IVIG = intravénás immunglobulin; LMVH = alacsony molekulatömegű heparin; MDS = myelodysplasiás szindróma; TTP = thromboticus thrombocytopeniás purpura Thrombocytopeniáról beszélünk, ha a thrombocytaszám alacsony. Általában a normálérték alsó határát (<150×109/L) tekintjük küszöbnek, azonban a 100× 109/L alatti érték elfogadása mellett is szólnak érvek [1]. Ezek közé tartozik az, hogy így elkerülhetjük a teendőt...

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Immunoreactions Involving Platelets. Vi. Reactions of Maternal Isoantibodies Responsible for Neonatal Purpura. Differentiation of a Second Platelet Antigen System*

Cited by 85 publications

References 20 publications

Leukocyte Grouping. A Method and Its Application*

Leukocyte Grouping. A Method and Its Application*

Nouvelle Cuisine: Platelets Served with Inflammation

Thrombocytopenia

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