Immunoreactive atrial natriuretic factor is increased in ovine model of endotoxemia

Lubbesmeyer, H. J.; Woodson, Lee C.; Traber, Lillian D.; Flynn, John T.; Herndon, David N.; Traber, Daniel L.

doi:10.1152/ajpregu.1988.254.4.r567

Cited by 9 publications

(9 citation statements)

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“…Therefore, it appears that peptidases that degrade ANF are not induced during systemic inflammation, but rather it is the secretion of ANF that is induced. These data are consistent with the observed elevations in plasma ANF after LPS challenge that have been observed in sheep (48) and dogs (49). Given the inverse correlation between plasma OpdB activity and plasma ANF levels, we believed it plausible that OpdB released by trypanosomes into the rat circulation could modulate plasma ANF levels.…”

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confidence: 92%

Oligopeptidase B from Trypanosoma evansi

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et al. 2005

Journal of Biological Chemistry

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, and plasma ANF levels inversely correlated with plasma OpdB activity. The in vitro halflife of ANF in rat plasma was reduced 300-fold in plasma from T. evansi-infected rodents, which contains high levels of OpdB activity. Addition of OpdB inhibitors to cell-free plasma from infected rodents significantly abrogated this ANF hydrolysis. Furthermore the in vivo ANF half-life was reduced 5-fold in T. evansi-infected rats. Thus, we propose a role for OpdB in peptide hormone dysregulation in trypanosomiasis, specifically in generating the depressed plasma levels of ANF in mammals infected with T. evansi.

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supporting

confidence: 92%

Oligopeptidase B from Trypanosoma evansi

Morty

Pellé

Vadász

et al. 2005

Journal of Biological Chemistry

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“…The first observations that ANP may play a role during endotoxic shock came from animal studies in which ANP was elevated within 2–6 hours after lipopolysaccharide injection [32,33]. Subsequent studies in critically ill humans showed an association of ANP with various cardiac physiological parameters [34,35].…”

Section: Discussionmentioning

confidence: 99%

Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study

et al. 2004

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Introduction Additional biomarkers in sepsis are needed to tackle the challenges of determining prognosis and optimizing selection of high-risk patients for application of therapy. In the present study, conducted in a cohort of medical intensive care unit patients, our aim was to compare the prognostic value of mid-regional pro-atrial natriuretic peptide (ANP) levels with those of other biomarkers and physiological scores. Methods Blood samples obtained in a prospective observational study conducted in 101 consecutive critically ill patients admitted to the intensive care unit were analyzed. The prognostic value of pro-ANP levels was compared with that of the Acute Physiology and Chronic Health Evaluation (APACHE) II score and with those of various biomarkers (i.e. C-reactive protein, IL-6 and procalcitonin). Mid-regional pro-ANP was detected in EDTA plasma from all patients using a new sandwich immunoassay. Results On admission, 53 patients had sepsis, severe sepsis, or septic shock, and 68 had systemic inflammatory response syndrome. The median pro-ANP value in the survivors was 194 pmol/l (range 20-2000 pmol/l), which was significantly lower than in the nonsurvivors (median 853.0 pmol/l, range 100-2000 pmol/l; P < 0.001). On the day of admission, pro-ANP levels, but not levels of other biomarkers, were significantly higher in surviving than in nonsurviving sepsis patients (P = 0.001). In a receiver operating characteristic curve analysis for the survival of patients with sepsis, the area under the curve (AUC) for pro-ANP was 0.88, which was significantly greater than the AUCs for procalcitonin and C-reactive protein, and similar to the AUC for the APACHE II score. Conclusion Pro-ANP appears to be a valuable tool for individual risk assessment in sepsis patients and for stratification of high-risk patients in future intervention trials. Further studies are needed to validate our results.

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“…Based on physiological principles, the plasma levels of ANP would be expected to be lower in states of hypovolaemia (Levin et al 1998). However, ANP is increased during experimental endotoxic shock in sheep (Lubbesmeyer et al 1988;Redl et al 1992;Hinder et al 1996), and this is also seen in septic human subjects (Mitaka et al 1990). In endotoxic rats, plasma ANP concentrations have been shown initially to decrease, but then increase by 6 h and remain increased at 24 h (Aiura et al 1995).…”

Section: Introductionmentioning

confidence: 99%