Immunoreactive circulating endothelin‐1 in normal and hypertensive pregnancies

Schiff, Eyal; Ben-Baruch, G.; Peleg, Edna; Rosenthal, Talma; Alcalay, M.; Devir, M; Mashiach, S

doi:10.1016/0020-7292(92)90954-h

Cited by 27 publications

(38 citation statements)

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“…In this study, a significant increase in plasma ET-1 level and Th1:Th2 imbalance was observed in patients with preeclampsia which was in accordance with results of previous studies [1][2][3][4][10][11][12]. In addition, there were significant correlations between plasma ET-1 levels and Th2 cells in patients with preeclampsia and in all subjects in general.…”

Section: Discussionsupporting

confidence: 81%

“…In preeclampsia, an increase in the maternal circulation of strong vasoconstrictor factors such as endothelin 1 (ET-1) has been reported [1][2][3][4]. However, the origin of this increase in preeclampsia remains to be elucidated, although most investigators have hypothesized that it may be caused by systemic endothelial cell activation or dysfunction [1,5].…”

Section: Introductionmentioning

confidence: 97%

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Relation between Plasma Endothelin 1 Levels and T Helper 1: T Helper 2 Cell Immunity in Women with Preeclampsia

Kuwajima

Suzuki²,

Yoneyama³

et al. 2001

Gynecol Obstet Invest

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The aim of this study was to investigate the relationship between plasma endothelin 1 (ET-1) levels and T helper (Th)-1:Th2 cell immunity in women with preeclampsia. The percentage of Th1 and Th2 cells and the Th1:Th2 cell ratios in peripheral blood from 11 normal pregnant women and 11 patients with preeclampsia at 29–34 weeks of gestation were calculated using flow cytometry. The plasma ET-1 level was also determined using a modified radioimmunoassay. The plasma ET-1 concentrations and the Th1:Th2 cell ratios in normal pregnancies were significantly lower than those in patients with preeclampsia. Negative correlations were found between plasma ET-1 levels and Th2 cells in both the preeclamptic pregnancy groups and in the normal pregnant women. Our results indicate that elevated ET-1 levels are associated with a Th1:Th2 imbalance in preeclampsia.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 97%

Relation between Plasma Endothelin 1 Levels and T Helper 1: T Helper 2 Cell Immunity in Women with Preeclampsia

Kuwajima

Suzuki²,

Yoneyama³

et al. 2001

Gynecol Obstet Invest

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“…In interference with relaxation factors, ET-1 plays an important role in regulating blood flow and blood pressure [17,18]. Previous reports on ET-1 concentrations in peripheral maternal plasma in patients with pre-eclampsia have been contradictory, some showing increased [4][5][6] and some normal values [7,8].…”

Section: Introductionmentioning

confidence: 98%

Peripartal Temporal Course of Endothelin 1, Angiotensin II, and Atrial Natriuretic Peptide in Pre-Eclampsia and Normotensive Pregnancy

Zunker¹,

Happe

Louwen

et al. 1998

Fetal Diagn Ther

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Objective: To investigate the temporal peripartal course of plasma endothelin 1 (ET-1), angiotensin II (ANG II), and atrial natriuretic peptide (ANP) in patients with pre-eclampsia as compared to women with normotensive pregnancy. Methods: Levels of ET-1, ANG II, and ANP were measured by means of radio-immunoassay twice a week in 17 patients with pre-eclampsia and in 17 women with normotensive uncomplicated pregnancy during four different periods: (a) from admission to 1 week before delivery, (b) 1st week before delivery, (c) 1st week after delivery, and (d) 2nd week after delivery. Results: ET-1 levels were not statistically different between the two groups. ANG II concentrations were lower in the pre-eclampsia group than in the control group with statistical significance in period c (2.8 ± 3.0 vs. 7.1 ± 5.9 pg/ml, mean ± SD). ANP levels were higher in pre-eclamptic women than in the control group, the difference being statistically significant in period a (54 ± 46 vs. 11 ± 16 pg/ml) and in period c (122 ± 134 vs. 39 ± 22 pg/ml). Conclusions: There are considerable differences in ANP and ANG II concentrations during the peripartal period between patients with pre-eclampsia and normotensive pregnant women. Decreased ANG II and elevated ANP levels in the 1st week postpartum may reflect the clinical observation that some women deteriorate in this period.

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“…It has been demonstrated that multiple mechanisms contribute to the increased vascular resistance during PE, including increased vascular sensitivity to angiotensin II (ANG II) [4,5], the presence of angiotensin II receptor-1 (AT 1 ) autoantibody [2,6], an imbalance between the vasoconstrictor thromboxane (TX) and decreased vasodilator prostacyclin (PGI2) [7,8], and altered endothelin (ET) [9,10] and nitric oxide (NO) [11] levels in both the maternal circulation and in the placenta in women with PE. These alterations may result in a detrimental positive feedback system that promotes inflammation and further vasoconstriction.…”

Section: Introductionmentioning

confidence: 99%

Vasoreactivity of Chorionic Plate Arteries in Response to Vasoconstrictors Produced by Preeclamptic Placentas

2007

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Inadequate blood flow and increased vasoconstriction of the placenta contribute to pregnancy associated disorders such as preeclampsia (PE). Because placental vessels lack autonomic innervation, humoral effects of the placenta must play critical roles in regulation of fetal-placental vascular contractility. In this study, we examined the nature of humoral factors produced by PE trophoblasts on placental vessel contractility using an organ bath perfusion model. Vasomotor responses were studied in vitro using placental chorionic plate arteries. Vessel rings from third branch chorionic plate arteries were dissected from human placentas following normal or PE delivery. The arterial rings were equilibrated in Krebs Henseleit buffer and exposed to placental conditioned medium, which was prepared by culture of villous tissue from PE placentas. Receptor antagonists for angiotensin II (ANG II), thromboxane (TX), and endothelin (ET) were used to determine which humoral factor produced by placental tissue (trophoblasts) was more effective in promoting vasoconstriction. The role of angiotensin converting enzyme (ACE) and non-ACE ANG II generating enzymes in regulation of placental vasomotor tone were also investigated. A total of 80 arterial rings from 48 placentas were studied. Our results showed: 1) enhanced vasomotor tone in arteries from PE placentas compared to those from normal placentas; 2) PE-CM induced vaso-constrictive activity could be partially attenuated by receptor antagonists for TX, ANG II and ET, respectively; and 3) chymostatin (a chymase inhibitor) produced a stronger inhibitory effect than captopril (ACE inhibitor) on PE conditioned medium induced vasoconstriction. Our data demonstrate increased vasocontractility in PE placentas and suggest that the non-ACE pathway is probably a major source of ANG II produced in the human placenta.

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Immunoreactive circulating endothelin‐1 in normal and hypertensive pregnancies

Cited by 27 publications

References 0 publications

Relation between Plasma Endothelin 1 Levels and T Helper 1: T Helper 2 Cell Immunity in Women with Preeclampsia

Relation between Plasma Endothelin 1 Levels and T Helper 1: T Helper 2 Cell Immunity in Women with Preeclampsia

Peripartal Temporal Course of Endothelin 1, Angiotensin II, and Atrial Natriuretic Peptide in Pre-Eclampsia and Normotensive Pregnancy

Vasoreactivity of Chorionic Plate Arteries in Response to Vasoconstrictors Produced by Preeclamptic Placentas

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