Immunoreactive inhibin levels during ovarian stimulation may predict granulosa cell maturity

Buckler, Helen; Robertson, W. R.; Sun, Jianlong; Morris, Ian D.

doi:10.1111/j.1365-2265.1992.tb01487.x

Cited by 15 publications

(6 citation statements)

References 14 publications

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“…Increase of inhibin serum levels is apparently the earlier pharmacodynamic marker that the dose given will be effective, and careful inspection of the data indicates that, if after 1 week of treatment, inhibin serum levels are Ͼ5 U/mL, a significant follicular development reasonably can be expected. Besides being an early index of follicular development, inhibin has been shown to be an index of follicular maturation (22) and a prediction of follicle quality (11). Together, this suggests the need for further investigations of the use of inhibin as a useful clinical index for monitoring FSH treatment.…”

Section: Smentioning

confidence: 99%

Clinical Pharmacology of Recombinant Human Follicle-Stimulating Hormone. III. Pharmacokinetic-Pharmacodynamic Modeling After Repeated Subcutaneous Administration

Porchet¹,

Cotonnec²,

Loumaye³

1998

Fertility and Sterility

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Section: Smentioning

confidence: 99%

Clinical Pharmacology of Recombinant Human Follicle-Stimulating Hormone. III. Pharmacokinetic-Pharmacodynamic Modeling After Repeated Subcutaneous Administration

Porchet¹,

Cotonnec²,

Loumaye³

1998

Fertility and Sterility

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“…It was reported that human ovarian cystic fluids produced a marked inhibition of FSH-binding activity in the absence of an effect on FSH or LH secretion [38]. Polycystic ovarian syndrome (PCOS) is the most common pathological cystic ovarian disease in human and is associated with a deficit in the paracrine control of folliculogenesis [4]. Autocrine/paracrine factors, especially those which are FSH-dependent, e.g.…”

Section: Discussionmentioning

confidence: 99%

“…They are developmentally and physiologically important growth factors with structural homology to a large group of proteins including the transforming growth factor-β (TGF-β) [51], and have been reported to play a role in cystic ovarian diseases [4,5,19]. Similar to other members of the TGF-β family, inhibins interact with cell surface receptors [29].…”

mentioning

confidence: 99%

Serous Cysts Are a Benign Component of the Cyclic Ovary in the Guinea Pig with an Incidence Dependent upon Inhibin Bioactivity.

et al. 2002

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ABSTRACT. Ovaries were collected from normal cycling female guinea pigs on each day of the estrous cycle (n=5 per day) for histological analysis of ovarian morphology. Three types of ovarian cysts were observed: serous cysts, follicular cysts and parovarian cysts. The most common were serous cysts (cystic rete ovarii), which were present throughout the estrous cycle with an overall incidence of 63.5% (54 out of 85 animals). Follicular cysts occurred in 22.4% of guinea pigs overall (19 out of 85). Only one parovarian cyst (1 out of 85) was observed in the present experiment. Follicular cysts always coincided with serous cysts and were less common during diestrus. The incidence of serous cysts did not vary significantly across the estrous cycle. In a second experiment, cycling female guinea pigs were arrested in a prolonged luteal phase by a progesterone implant in order to achieve ovarian synchrony. They were then treated with inhibin antiserum (0.5 or 1 ml per animal i.v.; n=6 per group) or normal goat serum (controls; n=6 per group). There was a dose dependent increase in the incidence of serous ovarian cysts following passive immunization against the inhibin α-subunit. These results suggest that serous cysts are a normal component of the cyclic guinea pig ovary and that alterations in the inhibin-follicle-stimulating hormone system appear to modulate the incidence of serous ovarian cysts in this species. KEY WORDS: guinea pig, inhibin, ovarian cyst, passive immunization, serous cyst.

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“…However, a high degree of assay specificity does not seem to be required for all clinical applications of inhibin measures, as previously suggested (14). For example, ␣-inhibin levels may be used as a valuable index of granulosa cell (GC) activity or maturity (15,16), as the majority of serum immunoreactive inhibin is thought to arise from the GC in nonpregnant women.…”

Section: Nhibins Are Dimeric Glycoproteins Consisting Of Anmentioning

confidence: 91%

Serum α-Inhibin Levels in Polycystic Ovary Syndrome: Relationship to the Serum Androstenedione Level1

Pigny

Desailloud

Cortet‐Rudelli

et al. 1997

The Journal of Clinical Endocrinology &Amp; Metabolism

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To date, only one study has demonstrated increased serum inhibin levels in women with polycystic ovary syndrome (PCOS). Moreover, no relationship between serum inhibin and either FSH or androgen levels has been noted. This lack of data could be due to 1) the heterogeneity of PCOS and the small sample size of previous studies, and/or 2) the complexity of circulating inhibin molecular forms, which hinders the precise evaluation of bioactive inhibin. In the present study, ␣-inhibin levels were assayed in the serum of 61 healthy women and 72 PCOS patients by means of an ␣-␣ enzyme-linked immunosorbent assay. Serum ␣-inhibin levels together with LH and androstenedione (A) levels were significantly increased in PCOS women (mean Ϯ SD, 1.45 Ϯ 0.55 vs. 0.94 Ϯ 0.36 U/mL in controls; P Ͻ 0.001). Moreover, simple and partial regression analysis demonstrated that serum A levels were positively and independently correlated to serum ␣-inhibin (r ϭ 0.32; P Ͻ 0.01) and LH levels (r ϭ 0.48; P Ͻ 0.001) in PCOS. The respective influences of ␣-inhibin and LH on A variability were 20% and 80%, as determined by multiple regression analysis. In conclusion, in agreement with recent in vitro data, our in vivo results argue for a role of inhibin in the hyperandrogenism of PCOS together with, but independently from, that of LH. Further studies are needed to determine whether this effect is produced by inhibin A and/or B.

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Immunoreactive inhibin levels during ovarian stimulation may predict granulosa cell maturity

Cited by 15 publications

References 14 publications

Clinical Pharmacology of Recombinant Human Follicle-Stimulating Hormone. III. Pharmacokinetic-Pharmacodynamic Modeling After Repeated Subcutaneous Administration

Clinical Pharmacology of Recombinant Human Follicle-Stimulating Hormone. III. Pharmacokinetic-Pharmacodynamic Modeling After Repeated Subcutaneous Administration

Serous Cysts Are a Benign Component of the Cyclic Ovary in the Guinea Pig with an Incidence Dependent upon Inhibin Bioactivity.

Serum α-Inhibin Levels in Polycystic Ovary Syndrome: Relationship to the Serum Androstenedione Level1

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