Immunoreactive proteins of<i>Campylobacter concisus</i>, an emergent intestinal pathogen

Kovách, Zsuzsanna; Kaakoush, Nadeem O.; Lamb, Sarah; Zhang, Li; Raftery, Mark J.; Mitchell, Hazel M.

doi:10.1111/j.1574-695x.2011.00864.x

Cited by 28 publications

(24 citation statements)

References 35 publications

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“…Further studies conducted by us and others, have supported this finding in patients with CD71 107 108 and UC 29 70 72 109. Moreover, recent advances suggest that C. concisus is an immunogenic micro-organism as C. concisus flagellin B, ATP synthase F1 α subunit and outer membrane protein 18 have been shown to be consistently recognised by all patients with CD110 while Campylobacteraceae DNA has been found in the lymph nodes of patients with CD 111…”

Section: Discussionmentioning

confidence: 62%

Dual role ofHelicobacterandCampylobacterspecies in IBD: a systematic review and meta-analysis

Castaño-Rodríguez

Kaakoush

Lee

et al. 2015

Gut

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Section: Discussionmentioning

confidence: 62%

Dual role ofHelicobacterandCampylobacterspecies in IBD: a systematic review and meta-analysis

Castaño-Rodríguez

Kaakoush

Lee

et al. 2015

Gut

187

206

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“…In line with this, a study by Kovach and colleagues identified 37 immunoreactive proteins of C. concisus, detected using sera collected from 10 C. concisus-positive children with CD (97). Of these proteins, flagellin B, the ATP synthase F1 ␣ subunit, and outer membrane protein 18 were consistently recognized by all CD patients (97).…”

Section: Inflammatory Bowel Diseasesmentioning

confidence: 54%

Global Epidemiology of Campylobacter Infection

et al. 2015

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SUMMARY Campylobacter jejuni infection is one of the most widespread infectious diseases of the last century. The incidence and prevalence of campylobacteriosis have increased in both developed and developing countries over the last 10 years. The dramatic increase in North America, Europe, and Australia is alarming, and data from parts of Africa, Asia, and the Middle East indicate that campylobacteriosis is endemic in these areas, especially in children. In addition to C. jejuni , there is increasing recognition of the clinical importance of emerging Campylobacter species, including Campylobacter concisus and Campylobacter ureolyticus . Poultry is a major reservoir and source of transmission of campylobacteriosis to humans. Other risk factors include consumption of animal products and water, contact with animals, and international travel. Strategic implementation of multifaceted biocontrol measures to reduce the transmission of this group of pathogens is paramount for public health. Overall, campylobacteriosis is still one of the most important infectious diseases that is likely to challenge global health in the years to come. This review provides a comprehensive overview of the global epidemiology, transmission, and clinical relevance of Campylobacter infection.

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“…Infection with C. concisus can predispose individuals to the development of microscopic colitis and irritable bowel syndrome (6,7). Furthermore, this bacterium has been associated with the development of more severe chronic conditions, such as inflammatory bowel diseases (IBD) (8)(9)(10)(11)(12)(13)) and Barrett's esophagus (14,15).…”

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confidence: 99%

Transcriptomic and Proteomic Analyses Reveal Key Innate Immune Signatures in the Host Response to the Gastrointestinal Pathogen Campylobacter concisus

et al. 2015

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e Pathogenic species within the genus Campylobacter are responsible for a considerable burden on global health. Campylobacter concisus is an emergent pathogen that plays a role in acute and chronic gastrointestinal disease. Despite ongoing research on Campylobacter virulence mechanisms, little is known regarding the immunological profile of the host response to Campylobacter infection. In this study, we describe a comprehensive global profile of innate immune responses to C. concisus infection in differentiated THP-1 macrophages infected with an adherent and invasive strain of C. concisus. Using RNA sequencing (RNAseq), quantitative PCR (qPCR), mass spectrometry, and confocal microscopy, we observed differential expression of pattern recognition receptors and robust upregulation of DNA-and RNA-sensing molecules. In particular, we observed IFI16 inflammasome assembly in C. concisus-infected macrophages. Global profiling of the transcriptome revealed the significant regulation of a total of 8,343 transcripts upon infection with C. concisus, which included the activation of key inflammatory pathways involving CREB1, NF-B, STAT, and interferon regulatory factor signaling. Thirteen microRNAs and 333 noncoding RNAs were significantly regulated upon infection, including MIR221, which has been associated with colorectal carcinogenesis. This study represents a major advance in our understanding of host recognition and innate immune responses to infection by C. concisus. Anumber of Campylobacter species, in addition to Campylobacter jejuni and Campylobacter coli, are now recognized as human and animal pathogens (1). Campylobacter concisus, first isolated from the oral cavity of humans in 1981 (2), is an emergent pathogen of the human gastrointestinal tract (3). C. concisus is a causative agent of a more prolonged but less severe form of acute gastroenteritis compared to that caused by C. jejuni (4-6). Infection with C. concisus can predispose individuals to the development of microscopic colitis and irritable bowel syndrome (6, 7). Furthermore, this bacterium has been associated with the development of more severe chronic conditions, such as inflammatory bowel diseases (IBD) (8-13) and Barrett's esophagus (14,15).Studies of C. concisus virulence factors have identified distinct pathogenic traits within different strains, which have been used to classify C. concisus strains into potential pathotypes, including adherent and invasive C. concisus (AICC) and adherent and toxigenic C. concisus (AToCC), in addition to nonpathogenic strains (16). The basis of this division arises from the ability of AICC to invade host cells and evade autophagy, thereby accumulating within host cells to intracellular levels 500-fold greater than those of other C. concisus strains (17-19), while AToCC strains produce a zonula occludens toxin with the potential to target tight junctions of host cells (20). A restriction-modification (R-M) system specific to AICC strains has been hypothesized to be involved in the ability of these strains to manipul...

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Immunoreactive proteins ofCampylobacter concisus, an emergent intestinal pathogen

Cited by 28 publications

References 35 publications

Dual role ofHelicobacterandCampylobacterspecies in IBD: a systematic review and meta-analysis

Dual role ofHelicobacterandCampylobacterspecies in IBD: a systematic review and meta-analysis

Global Epidemiology of Campylobacter Infection

Transcriptomic and Proteomic Analyses Reveal Key Innate Immune Signatures in the Host Response to the Gastrointestinal Pathogen Campylobacter concisus

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