Immunoreactive‐somatostatin concentrations of the human stomach and mood state in patients with functional dyspepsia: A preliminary case–control study

Abstract

Immunoreactive-somatostatin (ir-SS) concentrations of the gastric mucosa and mood state in patients with functional dyspepsia were examined. The subjects were 12 patients with upper abdominal discomfort, nausea and/or vomiting (motility disorder group) and 14 patients complaining of upper abdominal pain (ulcer-like disorder group) for more than a month without any organic upper-gastrointestinal tract disease proven by endoscopy. These patients were compared with either an age- and sex-matched group of asymptomatic outpatients without any organic disease (control group: n = 26) or to a group of patients with peptic ulcer (n = 19). Somatostatin concentrations of the stomach were measured by radio-immunoassay, and the mood state of each subject was assessed by Manifest Anxiety Scale (MAS) and Self-rating Depression Scale test. Immunoreactive-somatostatin concentrations of the gastric mucosa were significantly higher in the ulcer-like disorder group than in the peptic ulcer, motility disorder or control group, and gastric juice levels were higher in the ulcer-like disorder group. The psychometric tests showed that the motility disorder group was more depressive than the ulcer-like disorder group, but there were no differences between the motility disorder, ulcer-like disorder and peptic ulcer group in MAS scores or environmental factors. These results indicate that there may be two different subgroups in functional dyspepsia influenced by both ir-SS concentration of the stomach and/or mood state.

Functional gastrointestinal disorders: psychological, social, and somatic features

“…Despite substantial differences in experimental design, the relations found in this study between type of distress and type of FGID support previous associations (for example, depression with DL dyspepsia27; hypochondriasis with IBS28-30; and emotional distress (anxiety and depression) with heartburn/reflux31). The present findings, however, shed further light on how personality, chronic social stressors, and distress may differentially influence the development and/or exacerbation of FGID.…”

Evidence-based clinical practice guidelines for functional dyspepsia

“…Similarly, 6 months after H. pylori eradication, approximately 27 % of the treated FD patients had a recurrence [79]. Some previous studies have suggested that psychological problems are more commonly seen in FD patients than in patients with peptic ulcer disease and healthy controls [80,81], but another study indicates that psychological problems in FD patients occurred at the same frequency as in healthy individuals [82]. A meta-analysis based on studies that were performed up to 2001 suggested that there was no significant difference in the ratios of affective disorders and neurotic disorders between FD patients and healthy individuals [23].…”

Demography and treatment response in patients with predominant non‐erosive reflux disease or functional dyspepsia

“…Recently, it has been suggested that exposure of the esophagus and duodenum to gastric acid is also a cause of dyspepsia symptoms . Furthermore, several common pathophysiological features such as hyperesthesia and abnormal motor function, as well as psychological factors, are observed with both conditions . Nevertheless, there is ongoing discussion concerning the differences between these two diseases .…”

“…4,14-16 Furthermore, several common pathophysiological features such as hyperesthesia and abnormal motor function, as well as psychological factors, are observed with both conditions. [17][18][19][20][21][22][23][24][25] Nevertheless, there is ongoing discussion concerning the differences between these two diseases. 6,7 To investigate this issue, we compared demographics and treatment response to the proton pump inhibitor lansoprazole between patients with FD and patients with NERD.…”