Immunoreactivity of B-Cell Markers (CD79a, L26) in Rare Cases of Extranodal Cytotoxic Peripheral T- (NK/T-) Cell Lymphomas

Blakolmer, Karin; Vesely, Michael; Kummer, J. Alain; Jurecka, Wolfgang; Mannhalter, Christine; Chott, Andreas

doi:10.1038/modpathol.3880133

Cited by 80 publications

(72 citation statements)

References 18 publications

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“…Immunohistochemical studies revealed that neoplastic cells from the first patient were CD20 + , CD79a [4][5][6][7][8][9]. Cells from the patient with a small intestinnal lymphoma exhibited a similar phenotype, but also demonstrated positive reactivity for CD56.…”

Section: Resultsmentioning

confidence: 92%

“…We recently evaluated two such CD20-positive T cell lymphomas. We present these cases herein and review those previously reported [6][7][8][9][10][11][12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 87%

“…More than 10 cases of CD20-positive T cell lymphoma have been reported 6,8,9,[11][12][13][14][15][16] ( Table 2). Given that as high a proportion as 12% of normal peripheral blood can coexpress CD20dim and CD3, Quintanilla-Martinez et al 9 concluded that the CD20-positive T cell lymphoma phenotype was not aberrant, but instead represented the neoplastic counterpart of a small subpopulation of normal peripheral blood T cells.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the liver biopsy was performed thirteen months after the initial operation, raising the possibility that the characteristics of the neoplastic cells might have changed in that time. In two of four CD79a-positive peripheral T cell lymphomas reported by Blakolmer et al 8 , biopsies each from two different sites were obtained ; the neoplastic cells were positive for CD79a, while the lymphomatous tissue at the site of the second biopsy was negative. The authors questioned the legitimacy of this result, hypothesizing that the observed expression of CD79a might result from cross-reactivity with an unknown epitope.…”

Section: Discussionmentioning

confidence: 99%

“…Blakolmer et al 8 investigated 94 extranodal non-B cell lymphoma cases, including 52 enteropathy-type intestinal T cell lymphoma, 11 cases of nasal NK/T cell lymphoma, 31 patients with primary cutaneous peripheral T cell lymphoma, and 17 instances of nodal peripheral T cell lymphoma, unspecified. Four of these cases, including three cases of enteropathy-type intestinal T cell lymphoma and one of NK/T cell lymphoma, expressed both T and B cell-specific surface markers.…”

Section: Discussionmentioning

confidence: 99%

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CD20-Positive Cytotoxic T Cell Lymphoma: Report of Two Cases and Review of the Literature

Kitamura

Yamashita

Mori

2005

J Clin Exp Hematopathol

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We explored two cases of CD20-positive cytotoxic T cell lymphoma, a gastric lymphoma and an intestinal lymphoma. Neoplastic cells of the gastric lesion, possessing small cleaved-like nuclei with dense nuclear chromatin, infiltrated the mucosa in association with disappearance of the gastric glands. Neoplastic cells of the intestinal case had large, round nuclei with conspicuous nucleoli, with ulceration of intestinal surface membrane. In both cases, the neoplastic cells exhibited CD3 + , CD4 − , CD8 + , CD20 + , CD79a − , perforin + , granzyme B + , TIA-1 + phenotypes. Neoplastic cells of the intestinal lesion also demonstrated positive reactivity for CD56. The gastric lymphoma was initially diagnosed as an extranodal marginal zone B-cell lymphoma, due to morphological similarity to gastric MALT lymphomas and CD20 positivity. Thus, CD20 expression on neoplastic cells in T cell lymphoma may complicate accurate diagnosis. In this report, we review previously reported CD20-positive T cell lymphoma cases, reinforcing our suggestion that recognition of this type of CD20+ lymphoma is important in making a correct diagnosis and providing adequate therapy for patients.

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Section: Resultsmentioning

confidence: 92%

“…We recently evaluated two such CD20-positive T cell lymphomas. We present these cases herein and review those previously reported [6][7][8][9][10][11][12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 87%