Immunoregulation of Autoimmunity by Natural Killer T Cells

Linsen, Loes; Somers, Veerle; Stinissen, Piet

doi:10.1016/j.humimm.2006.02.020

Cited by 72 publications

(46 citation statements)

References 115 publications

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“…In humans, approximately 40% to 60% of invariant NKT cells are CD4 + cells [12]. We previously reported that intrathyroidal CD4 + T cells strongly express Fas and that intrathyroidal CD4 + CD8 + macrophage/dendritic cells express Fas ligand in patients with AITD [9].…”

Section: Discussionmentioning

confidence: 94%

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Decrease of Intrathyroidal CD161+V.ALPHA.24+V.BETA.11+ NKT Cells in Graves' disease

et al. 2008

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Abstract. To clarify changes in the intrathyroidal natural killer T (NKT) cell subset, which prevents autoimmunity in patients with Graves' disease (GD), we examined intrathyroidal and peripheral lymphocytes in 11 patients with GD and peripheral lymphocytes in nine healthy volunteers using three-color flow cytometry. The proportion of CD161 + T cell receptor Vα24 + Vβ11 + cells, which represent the NKT cell subset, was lower in the thyroid of patients with GD than in the peripheral blood of the same patients and in the peripheral blood of healthy subjects. These results indicate that the proportion of intrathyroidal NKT cells is decreased in patients with GD and that this decrease may contribute to incomplete regulation of autoreactive T cells in GD.

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Section: Discussionmentioning

confidence: 94%

“…Natural killer T (NKT) cells are T cells that express the natural killer (NK) cell-associated marker NK1.1 (CD161) [12]. This subset is restricted by CD1d and expresses both a heavily biased, semi-invariant T cell receptor (TCR) and NK cell markers [13].…”

mentioning

confidence: 99%

Decrease of Intrathyroidal CD161+V.ALPHA.24+V.BETA.11+ NKT Cells in Graves' disease

et al. 2008

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“…[39][40][41] NKT cells exhibit powerful immune regulation over autoimmune disease. 42 The most well-known model is the type 1 diabetes-susceptible non-obese diabetic (NOD) mouse model, where adoptive transfer of NKT cells can prevent diabetes onset, 43,44 presumably by IL-4-mediated skewing of CD4 1 T cells toward Th2, thus preventing Th1-mediated autoimmune responses in NOD mice. 45 Moreover, NKT cells can also suppress immune responses by secreting IL-10 in autoimmune disease.…”

Section: 22mentioning

confidence: 99%

The liver works as a school to educate regulatory immune cells

Tian

2013

Cell Mol Immunol

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Because of its unique blood supply, the liver maintains a special local immune tolerogenic microenvironment. Moreover, the liver can impart this immune tolerogenic effect on other organs, thus inducing systemic immune tolerance. The network of hepatic regulatory cells is an important mechanism underlying liver tolerance. Many types of liver-resident antigen-presenting cells (APCs) have immune regulatory function, and more importantly, they can also induce the differentiation of circulating immune cells into regulatory cells to further extend systemic tolerance. Thus, the liver can be seen as a type of 'school,' where liver APCs function as 'teachers' and circulating immune cells function as 'students.'

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“…Natural killer (NK) cells are large granular lymphocytes that were first identified in mice because of their capacity to spontaneously lyse certain tumour cells [14]. In recent years, NK cells have been appreciated to act as an important regulator for Th1 cell-mediated autoimmune diseases [15][16][17]. NK cells also share many functions with T cells such as the release of regulatory cytokines (e.g.…”

Section: Introductionmentioning

confidence: 99%

Passive Transfer of Experimental Autoimmune Neuritis by IL‐12 and IL‐18 Synergistically Potentiated Lymphoid Cells is Regulated by NKR‐P1+ Cells

Sun

Wang

et al. 2007

Scand J Immunol

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The aim of this study was to investigate the roles and mechanism of interleukin‐12 (IL‐12) and interleukin‐18 (IL‐18) in potentiating the autoreactivity of lymphoid cells specific for P2 53–78 peptide. P2 53–78‐specific lymphoid cells in the presence of IL‐12 or IL‐18 alone passive transferred only moderate experimental autoimmune neuritis (EAN) into a low percentage of recipients. However, lymphoid cells co‐cultured with both cytokines transferred aggressive clinical and histological EAN into all recipients. NKR‐P1+ cells (including NK and NKT cells) played an immunosuppressive function in passive transfer EAN and depletion of NKR‐P1+ cells by anti‐NKR‐P1 Ab and complement induced a more serious form of EAN. Nevertheless, lymphoid cells co‐cultured with both IL‐12 and IL‐18 induced high levels of interferon‐γ (IFN‐γ) and promoted Th1 differentiation partially through NKR‐P1+ cells and to some extent, NKR‐P1+ cell depletion inhibited the auto‐reactivity of lymphoid cells treated with IL‐12 and IL‐18.

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Immunoregulation of Autoimmunity by Natural Killer T Cells

Cited by 72 publications

References 115 publications

Decrease of Intrathyroidal CD161+V.ALPHA.24+V.BETA.11+ NKT Cells in Graves' disease

Decrease of Intrathyroidal CD161+V.ALPHA.24+V.BETA.11+ NKT Cells in Graves' disease

The liver works as a school to educate regulatory immune cells

Passive Transfer of Experimental Autoimmune Neuritis by IL‐12 and IL‐18 Synergistically Potentiated Lymphoid Cells is Regulated by NKR‐P1+ Cells

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