Immunoregulation with levamisole

Symoens, J.; Rosenthal, M.; Brabander, M. De; Goldstein, Gideon

doi:10.1007/bf00201973

Cited by 30 publications

(3 citation statements)

References 35 publications

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“…Its use quickly fell out of favor, as it showed no benefit in the treatment of the disease. 7 It was then used for its immunomodulating effects in the nephrotic syndrome in children. After prolonged clinical trials in Europe, numerous case reports had evidence linking levamisole to autoimmune vasculitis in many of the children.…”

Section: Disclosurementioning

confidence: 99%

Cocaine-Induced Full-Thickness Tissue Necrosis

Amalfi

Neumeister

Bueno

et al. 2013

Plastic and Reconstructive Surgery

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DISCLOSUREThe authors have no financial interest to declare in relation to the content of this article. Fig. 1. A 60-year-old woman who underwent resection of a liposarcoma on the right shoulder. (Left) The location of the perforating branches of the tenth intercostal artery in the lateral part of the latissimus dorsi muscle was detected by color Doppler sonography. The divided latissimus dorsi flap was designed to include the perforator in the distal flap. (Right) Three months after primary closure of the donor site.REFERENCES 1. Zhang YX, Messmer C, Pang FK, et al. A novel design of the multilobed latissimus dorsi myocutaneous flap to achieve primary donor-site closure in the reconstruction of large defects. Plast Reconstr Surg. 2013;131:752e-758e. 2. Sawaizumi M, Maruyama Y. Sliding shape-designed latissimus dorsi flap. Ann Plast Surg. 1997;38:41-45.

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Section: Disclosurementioning

confidence: 99%

Cocaine-Induced Full-Thickness Tissue Necrosis

Amalfi

Neumeister

Bueno

et al. 2013

Plastic and Reconstructive Surgery

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“…Clinical observations have also suggested benefit from levamisole treatment in recurrent urinary tract infections in children, recurrent pyogenic and mycotic infections and Crohn's disease. Further uncontrolled studies in chronic infections have revealed potential activity in acne conglobata, and leprosy as well as reversal of anergy associated with brucellosis, toxoplasmosis hepatitis, measles and in fluenza [reviewed in [3][4][5].…”

Section: Recurrent and Chronic Infectionsmentioning

confidence: 99%

“…Further discussions can be found in other recent reviews [4,5], Levamisole is rapidly absorbed, peak blood levels of 0.7 ,«g/ml (approximately 3 x 10-6 M ) being observed within 1-2 h of ingestion of a single 150-mg dose. It is rapidly metabolized in the liver and the half-life of the unchanged drug is 4 h. An interesting metabolite -OMP1 ( fig.…”

Section: Introductionmentioning

confidence: 99%

Levamisole and Immunotherapy: Some Theoretic and Practical Considerations and Their Relevance to Human Disease

Amery¹,

Gough²

1981

Oncology

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The major features of levamisole immunotherapy are distilled from experiences gained so far. The biochemical effects of levamisole are discussed in view of its effects on T lymphocytes and phagocytes. Potential indications for levamisole treatment are classified after Jerry et al. as immune deficiencies or as immune dysregulation syndromes (such as rheumatoid arthritis and cancer). After a scrutiny of investigations in cancer patients, the conclusion emerges that, in a subsection of patients, mainly those with poor prospects, levamisole improves the prognosis after effective chemotherapy, radiotherapy or surgery when given in time and in an appropriate dosage.

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Restoration of defective EAG-rosetting capacity of cancer patient neutrophils by levamisole

Patrone¹,

Dallegri

Pistoia

et al. 1985

Cancer

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Levamisole, used in vitro at therapeutic concentrations, was found able to restore the defective Fc‐receptor activity of cancer patient neutrophils. In addition, the drug prevented the inhibition of normal neutrophils Fc‐receptor function by cancer patient sera. The neutrophil Fc‐receptor function was also restored in six of seven cancer patients after in vivo administration of levamisole (2.5 mg/Kg/day for 3 days). Due to the central role played by the Fc‐receptor function in host defence mechanisms, including phagocytosis as well as antibody dependent cellular cytotoxicity, the capacity of levamisole to restore defective neutrophil Fc‐receptor function in cancer patients could contribute to the “immunomodulating” effect of the drug.

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Immunoregulation with levamisole

Cited by 30 publications

References 35 publications

Cocaine-Induced Full-Thickness Tissue Necrosis

Cocaine-Induced Full-Thickness Tissue Necrosis

Levamisole and Immunotherapy: Some Theoretic and Practical Considerations and Their Relevance to Human Disease

Restoration of defective EAG-rosetting capacity of cancer patient neutrophils by levamisole

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