Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

Amoriello, Roberta; Mariottini, Alice; Ballerini, Clara

doi:10.3389/fimmu.2021.799380

Cited by 18 publications

(6 citation statements)

References 112 publications

(204 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, using IIF and CTD Screen, a significant increase in the prevalence of ANA was found in those subjects with higher serum CRP levels, which could indicate the involvement of systemic inflammation in the development of systemic AID. In the same way, this finding could be related to the processes of immunosenescence and autoimmunity that are observed in aging people, in whom, the development of autoreactive T cells, as well as an increase in the production of autoantibodies, has been described [ 49 – 51 ]. Moreover, there is a relationship between immunosenescence and the development of a senescence-associated secretory phenotype (SASP), which has been associated with malignancy progression as well as with autoimmune disorders [ 51 – 54 ].…”

Section: Discussionmentioning

confidence: 88%

Prevalence and sociodemographic correlates of antinuclear antibody testing by indirect immunofluorescence or solid-phase assays in a Spanish population: the Camargo Cohort

Irure-Ventura,

Martínez-Revuelta,

López-Hoyos

et al. 2023

Immunol Res

View full text Add to dashboard Cite

Autoantibodies are the hallmark of autoimmunity, and specifically, antinuclear antibodies (ANA) are one of the most relevant antibodies present in systemic autoimmune diseases (AID). In the present study, we evaluate the relationship between ANA and sociodemographic and biobehavioral factors in a population with a low pre-test probability for systemic AID. ANA were determined in serum samples at baseline visit from 2997 participants from the Camargo Cohort using indirect immunofluorescence assay, and two solid phase assays (SPA), addressable laser bead immunoassay, and fluorescence enzyme immunoassay. Sociodemographic and biobehavioral features of the subjects were obtained at baseline visit using a structured questionnaire. The prevalence of ANA positive results was significantly higher when indirect immunofluorescence assay was used as screening method in comparison with SPAs, being higher in females, older subjects, and those with higher C-reactive protein levels. Considering biobehavioral features, the prevalence was higher in those individuals with a sedentary lifestyle, and in ex- and non-alcohol users. Moreover, considering the relevance of the antibody load using ANA Screen, the prevalence of the antibody load also increased with age, especially in females. In conclusion, the prevalence of ANA varies depending on sociodemographic and biobehavioral features of the subjects, which could be relevant specifically in a population with a low pre-test probability for systemic AIDs.

show abstract

Section: Discussionmentioning

confidence: 88%

Prevalence and sociodemographic correlates of antinuclear antibody testing by indirect immunofluorescence or solid-phase assays in a Spanish population: the Camargo Cohort

Irure-Ventura,

Martínez-Revuelta,

López-Hoyos

et al. 2023

Immunol Res

View full text Add to dashboard Cite

show abstract

“…The top ten KEGG pathways were shown in Supplementary Table S5 (containing the starting point) (Lasky, 1991 ; Reichardt, 2006 ; Allen et al, 2007 ; O'Callaghan et al, 2017 ; Conway, 2018 ; Gao et al, 2018 ; Kotelnikova et al, 2019 ; Plantone et al, 2019 ; Cui et al, 2020 ; Amoriello et al, 2021 ; Balkan and Bilge, 2021 ; Wu and Zhou, 2022 ; Chen et al, 2023 ; Leonard and Lin, 2023 ; Suptela and Marriott, 2023 ; Touil et al, 2023 ; Guerra-Espinosa et al, 2024 ). For example, one enriched pathway was “COMPLEMENT AND COAGULATION CASCADES,” where complement and coagulation were major blood-borne proteolytic cascades (Conway, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Identification of crucial inflammaging related risk factors in multiple sclerosis

Xu,

Wang,

Ren

et al. 2024

Front. Mol. Neurosci.

View full text Add to dashboard Cite

BackgroundMultiple sclerosis (MS) is an immune-mediated disease characterized by inflammatory demyelinating lesions in the central nervous system. Studies have shown that the inflammation is vital to both the onset and progression of MS, where aging plays a key role in it. However, the potential mechanisms on how aging-related inflammation (inflammaging) promotes MS have not been fully understood. Therefore, there is an urgent need to integrate the underlying mechanisms between inflammaging and MS, where meaningful prediction models are needed.MethodsFirst, both aging and disease models were developed using machine learning methods, respectively. Then, an integrated inflammaging model was used to identify relative risk factors, by identifying essential “aging-inflammation-disease” triples. Finally, a series of bioinformatics analyses (including network analysis, enrichment analysis, sensitivity analysis, and pan-cancer analysis) were further used to explore the potential mechanisms between inflammaging and MS.ResultsA series of risk factors were identified, such as the protein homeostasis, cellular homeostasis, neurodevelopment and energy metabolism. The inflammaging indices were further validated in different cancer types. Therefore, various risk factors were integrated, and even both the theories of inflammaging and immunosenescence were further confirmed.ConclusionIn conclusion, our study systematically investigated the potential relationships between inflammaging and MS through a series of computational approaches, and could present a novel thought for other aging-related diseases.

show abstract

“…There is in fact considerable evidence that both cellular and humoral immunity are affected by aging (although, there is more published evidence demonstrating age-related changes to the adaptive immune system, particularly T-cells) determining a state of apparent immunosuppression and autoreactivity (autoimmunity) (47)(48)(49). This is evidenced by the increased prevalence of infectious diseases in the elderly, both hospitalized and at home (11,12,50).…”

Section: Immunosenescence and Immunometabolismmentioning

confidence: 99%

Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging – from theory to practice

et al. 2022

View full text Add to dashboard Cite

Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced response to vaccine regimens. The loss of capacity for cell regeneration and the surrounding tissue microenvironment itself is conditioned by genetic, metabolic, and even environmental factors, such as nutrition. The senescence of the immune system (immunosenescence) represents a challenge, especially when associated with the presence of age-related chronic inflammation (inflammaging) and affecting the metabolic programming of immune cells (immunometabolism). These aspects are linked to poorer health outcomes and therefore present an opportunity for host-directed interventions aimed at both eliminating senescent cells and curbing the underlying inflammation. Senotherapeutics are a class of drugs and natural products that delay, prevent, or reverse the senescence process – senolytics; or inhibit senescence-associated secretory phenotype – senomorphics. Natural senotherapeutics from food sources – nutritional senotherapeutics – may constitute an interesting way to achieve better age-associated outcomes through personalized nutrition. In this sense, the authors present herein a framework of nutritional senotherapeutics as an intervention targeting immunosenescence and immunometabolism, identifying research gaps in this area, and gathering information on concluded and ongoing clinical trials on this subject. Also, we present future directions and ideation for future clinical possibilities in this field.

show abstract

Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

Cited by 18 publications

References 112 publications

Prevalence and sociodemographic correlates of antinuclear antibody testing by indirect immunofluorescence or solid-phase assays in a Spanish population: the Camargo Cohort

Prevalence and sociodemographic correlates of antinuclear antibody testing by indirect immunofluorescence or solid-phase assays in a Spanish population: the Camargo Cohort

Identification of crucial inflammaging related risk factors in multiple sclerosis

Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging – from theory to practice

Contact Info

Product

Resources

About