Immunosenescence profiles of lymphocyte compartments and multiple long-term conditions (multimorbidity) in very old adults: The Newcastle 85+ Study

Granic, Antoneta; Martin‐Ruiz, Carmen; Rimmer, Lucy; Dodds, Richard; Robinson, Louise; Spyridopoulos, Ioakim; Kirkwood, Thomas B. L.; Zglinicki, Thomas von; Sayer, Avan A.

doi:10.1016/j.mad.2022.111739

Cited by 2 publications

(3 citation statements)

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“…Similar to CD8 + T‐cells, late‐differentiated CD4 + EM T‐cell populations are expanded due to chronic antigen exposure 1,4,48 . The CD4 + CD45RO + CD27 – CD28 – phenotype combination is regarded as an adequate biomarker of senescence in late‐differentiated CD4 + T‐cells 48,49 .…”

Section: Resultsmentioning

confidence: 99%

“…ulations are expanded due to chronic antigen exposure. 1,4,48 The CD4 þ CD45RO þ CD27 -CD28phenotype combination is regarded as an adequate biomarker of senescence in late-differentiated CD4 þ T-cells. 48,49 Support for the relationship between CMV and CD4 þ T-cell frequencies or proportions was presented in 14 studies.…”

Section: Citationmentioning

confidence: 99%

“…1,4,48 The CD4 þ CD45RO þ CD27 -CD28phenotype combination is regarded as an adequate biomarker of senescence in late-differentiated CD4 þ T-cells. 48,49 Support for the relationship between CMV and CD4 þ T-cell frequencies or proportions was presented in 14 studies. 20,[22][23][24]26,29,30,33,34,36,[38][39][40]43 In the majority of these studies, CD4-subtype counts or proportions were investigated: seven studies (7/14; 50%) evaluated total CD4 þ T-cell frequencies and ≥1…”

Section: Citationmentioning

confidence: 99%

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Potential relationship between cytomegalovirus and immunosenescence: Evidence from observational studies

Gadoth,

Ourfalian,

Basnet

et al. 2024

Reviews in Medical Virology

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Immunosenescence (IS) occurs as a natural outcome of ageing and may be described as a decline in immune system flexibility and adaptability to sufficiently respond to new, foreign antigens. Potential factors that may precipitate IS include persistent herpesvirus infections, such as cytomegalovirus (CMV). Here, we conducted a review of the literature evaluating the potential association between CMV and IS. Twenty‐seven epidemiologic studies that included direct comparisons between CMV‐seropositive and CMV‐seronegative immunocompetent individuals were analysed. The majority of these studies (n = 20) were conducted in European populations. The strength of evidence supporting a relationship between CMV, and various IS‐associated immunologic endpoints was assessed. T‐cell population restructuring was the most prominently studied endpoint, described in 21 studies, most of which reported a relationship between CMV and reduced CD4:CD8 T‐cell ratio or modified CD8+ T‐cell levels. Telomere length (n = 4) and inflammageing (n = 3) were less frequently described in the primary literature, and the association of these endpoints with CMV and IS was less pronounced. An emergent trend from our review is the potential effect modification of the CMV‐IS relationship with both sex and age, indicating the importance of considering various effector variables when evaluating associations between CMV and IS. Our analysis revealed plausible mechanisms that may underlie the larger epidemiologic trends seen in the literature that support the indirect effect of CMV on IS. Future studies are needed to clarify CMV‐associated and IS‐associated immunologic endpoints, as well as in more diverse global and immunocompromised populations.

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Section: Resultsmentioning

confidence: 99%

Section: Citationmentioning

confidence: 99%

Section: Citationmentioning

confidence: 99%

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Potential relationship between cytomegalovirus and immunosenescence: Evidence from observational studies

Gadoth,

Ourfalian,

Basnet

et al. 2024

Reviews in Medical Virology

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A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs

Wambacq,

Apper,

Le Bourgot

et al. 2024

Front. Vet. Sci.

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IntroductionElderly dogs often suffer from chronic diseases, in part attributed to immunosenescence, characterized by reduced blood CD4+ T cells (helper T cells) and elevation in the CD8+ T cells subset (cytotoxic T cells). Studies conducted in adult dogs suggested that supplementing short chain fructo-oligosaccharides (scFOS) or postbiotics derived from yeasts may positively influence the immune response. The aim of the current study was to investigate whether dietary supplementation with a combination of scFOS with a new yeast postbiotic (Profeed ADVANCED® called scFOS+) could have a positive influence on the immune status of senior dogs subjected to an immune challenge (Lyme disease vaccination).MethodsTo this end, 22 healthy senior client-owned dogs were divided into two groups: one group received a placebo diet without scFOS+ and the other group the basal diet supplemented with 1.1% scFOS+. In order to assess immune function, complete blood count, serum acute phase proteins, immunoglobulins, cytokines, T-cell subsets and antibody secreting cells were analyzed. Furthermore, faecal score and pH were recorded.Results and discussionDogs fed the scFOS+ supplement had decreased total serum IgA concentrations (p < 0.01), which might suggest a more local IgA response in agreement with what was previously found when adult dogs were supplemented with β-1, 3/1, 6-glucan, a yeast-based product. More importantly, the present study demonstrated that feeding 1.1% scFOS+ to healthy senior dogs increased the CD4+:CD8+ T-cell (Helper:Cytotoxic T cell) ratio (p < 0.001) during and after vaccination against Lyme disease. Combining scFOS and yeast-derived postbiotics in the diet can therefore counter certain characteristics of T-cell immunosenescence in dogs.

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Immunosenescence profiles of lymphocyte compartments and multiple long-term conditions (multimorbidity) in very old adults: The Newcastle 85+ Study

Cited by 2 publications

References 64 publications

Potential relationship between cytomegalovirus and immunosenescence: Evidence from observational studies

Potential relationship between cytomegalovirus and immunosenescence: Evidence from observational studies

A new combination of a prebiotic and postbiotic mitigates immunosenescence in vaccinated healthy senior dogs

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