Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors

Lee, Ga Hye; Hong, Kyung Taek; Choi, Jung Yoon; Shin, Hee Young; Lee, Won Woo; Kang, Hyoung Jin

doi:10.1002/cti2.1124

Cited by 9 publications

(16 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, the prevalence of myelodysplasia and secondary malignancies increases after HSCT ( 64 ). An increase in senescent features and a reduction in cytokine production have been reported in T-cells of pediatric patients undergoing HSCT ( 48 ). Moreover, some studies have analyzed the effect of HSCT combined with total body irradiation or high-dose chemotherapy on the immune system of cancer patients.…”

Section: Effect Of Cancer Treatment Regimens On Immunosenescencementioning

confidence: 96%

Immunosenescence in Testicular Cancer Survivors: Potential Implications of Cancer Therapies and Psychological Distress

et al. 2021

View full text Add to dashboard Cite

Testicular cancer (TC) is the most frequent solid tumor diagnosed in young adult males. Although it is a curable tumor, it is frequently associated with considerable short-term and long-term morbidity. Both biological and psychological stress experienced during cancer therapy may be responsible for stimulating molecular processes that induce premature aging and deterioration of immune system (immunosenescence) in TC survivors, leading to an increased susceptibility to infections, cancer, and autoimmune diseases. Immunosenescence is a remodeling of immune cell populations with inversion of the CD4:CD8 ratio, accumulation of highly differentiated memory cells, shrinkage of telomeres, shift of T-cell response to Th2 type, and release of pro-inflammatory signals. TC survivors exposed to chemotherapy show features of immunological aging, including an increase in memory T-cells (CD4+ and CD8+) and high expression of the senescence biomarker p16INK4a in CD3+ lymphocytes. However, the plethora of factors involved in the premature aging of TC survivors make the situation more complex if we also take into account the psychological stress and hormonal changes experienced by patients, as well as the high-dose chemotherapy and hematopoietic stem cell transplantation that some individuals may be required to undergo. The relatively young age and the long life expectancy of TC patients bear witness to the importance of improving quality of life and of alleviating long-term side-effects of cancer treatments. Within this context, the present review takes an in-depth look at the molecular mechanisms of immunosenescence, describing experimental evidence of cancer survivor aging and highlighting the interconnected relationship between the many factors modulating the aging of the immune system of TC survivors.

show abstract

Section: Effect Of Cancer Treatment Regimens On Immunosenescencementioning

confidence: 96%

Immunosenescence in Testicular Cancer Survivors: Potential Implications of Cancer Therapies and Psychological Distress

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Donor age has also been claimed to affect significantly the occurrence and the quality of CMV immune recovery ( 25 ), in accordance to investigation on healthy subjects that showed an evolution of CMV T-cell immunity with increasing age ( 32 , 33 ). These issues may have a particular impact on patients receiving parent-derived haploidentical HSCT ( 34 ). Since T-lymphocytes from patients failing to clear CMV had a poorer cytokine release after challenge with CMV antigens, quality of CMV immune recovery is supposed to play an important role in controlling CMV reactivation ( 35 ).…”

Section: Management Of Viral Infections After Hsctmentioning

confidence: 99%

“…Patient age over 50 years is commonly considered as an adverse risk factor ( 101 ). Moreover, attention has been driven to the possible lymphocyte senescence in case of parental donor, possibly leading to a reduced antiviral response ( 34 ). In a previous study, EBV reactivation was more common among HSCT recipients with gamma-interferon 3/3 genotype ( 102 ).…”

Section: Management Of Viral Infections After Hsctmentioning

confidence: 99%

Viral Infections in HSCT: Detection, Monitoring, Clinical Management, and Immunologic Implications

et al. 2021

View full text Add to dashboard Cite

In spite of an increasing array of investigations, the relationships between viral infections and allogeneic hematopoietic stem cell transplantation (HSCT) are still controversial, and almost exclusively regard DNA viruses. Viral infections per se account for a considerable risk of morbidity and mortality among HSCT recipients, and available antiviral agents have proven to be of limited effectiveness. Therefore, an optimal management of viral infection represents a key point in HSCT strategies. On the other hand, viruses bear the potential of shaping immunologic recovery after HSCT, possibly interfering with control of the underlying disease and graft-versus-host disease (GvHD), and eventually with HSCT outcome. Moreover, preliminary data are available about the possible role of some virome components as markers of immunologic recovery after HSCT. Lastly, HSCT may exert an immunotherapeutic effect against some viral infections, notably HIV and HTLV-1, and has been considered as an eradicating approach in these indications.

show abstract

“…The distinctive traits of adaptive immunosenescence include the decline of naïve lymphocytes and increasing antigen-experienced lymphocytes, especially of the memory phenotype. The senescent lymphocytes have limited capacity in eliminating novel antigens, have a pro-inflammatory cytokine profile, favors the development of autoimmunity and can evade apoptosis [ 86 , 98 , 99 , 100 , 101 ].…”

Section: Age-associated Changes In the Adaptive Immune Systemmentioning

confidence: 99%

“…The aging cells losing CD28 yet gaining CD57 is another characteristic of immunosenescence, which reflects its diminished capacity to proliferate [ 16 , 98 , 103 ]. Lee et al also noted that stimulated CD28- T cells produce larger amounts of pro-inflammatory IFN-γ and TNF-α [ 99 ]. Senescent T cells that lost the CD28 expression also show resistance to apoptosis and diminished caspase 3 activity in response to apoptotic stimuli.…”

Section: Age-associated Changes In the Adaptive Immune Systemmentioning

confidence: 99%

Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System

Yeo

Nordin

et al. 2021

IJMS

View full text Add to dashboard Cite

Rapid growth of the geriatric population has been made possible with advancements in pharmaceutical and health sciences. Hence, age-associated diseases are becoming more common. Aging encompasses deterioration of the immune system, known as immunosenescence. Dysregulation of the immune cell production, differentiation, and functioning lead to a chronic subclinical inflammatory state termed inflammaging. The hallmarks of the aging immune system are decreased naïve cells, increased memory cells, and increased serum levels of pro-inflammatory cytokines. Mesenchymal stem cell (MSC) transplantation is a promising solution to halt immunosenescence as the cells have excellent immunomodulatory functions and low immunogenicity. This review compiles the present knowledge of the causes and changes of the aging immune system and the potential of MSC transplantation as a regenerative therapy for immunosenescence.

show abstract

Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors

Abstract: Immunosenescence in young HaploSCT patientsGH Lee et al.The conditioning regimen was composed of targeted busulfan with intensive pharmacokinetic monitoring, fludarabine (40 mg m À2 once daily via IV from days À8 to ª

Cited by 9 publications

References 75 publications

Immunosenescence in Testicular Cancer Survivors: Potential Implications of Cancer Therapies and Psychological Distress

Immunosenescence in Testicular Cancer Survivors: Potential Implications of Cancer Therapies and Psychological Distress

Viral Infections in HSCT: Detection, Monitoring, Clinical Management, and Immunologic Implications

Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System

Contact Info

Product

Resources

About