Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post‐Resection (Adv. Funct. Mater. 43/2022)

Hydrogel‐Based Strategies to Enhance T‐Cell Performance for Solid Tumor Immunotherapy

“…used TSBPA‐crosslinked poly(vinyl) alcohol (PVA) hydrogel to deliver STING agonist ADU‐S100 and an adeno‐associated virus (AAV) that released soluble PD‐1 to block PD‐1/PD‐L1 interaction and target remaining GBM tissues after surgical resection. [ 92 ] TSBPA is a material that can be degraded by reactive oxygen species. After injection with the hydrogel to cover up the resected area, radiotherapy (RT) was used to both kill tumor cells and add ROS into the hydrogel to break it down and release the therapeutic agents.…”

“…However, treatment of the hydrogel with all components and the radiotherapy successfully helped animal survival. [ 92 ] These experiments show that combination treatment of various therapies can be used synergistically and effectively.…”

“…[ 136 ] Like hypoxia and pH, hydrogel approaches to decrease ROS levels in the TME are not common, but ROS is often used as a trigger to degrade hydrogels to release drugs or other components upon delivery. [ 92,137 ] Recent progress on examining immune responses in response to these chemical barriers is necessary to improve actual patient therapy.…”

X‐Ray Excited Luminescence Materials for Cancer Diagnosis and Theranostics

“…In addition to widely explored biocompatible hydrogels, metalphenolic networks networks have been developed as novel coordination materials for various multifunctional nanoplatforms for biomedical applications. [103] Sang et al developed an oxygenrich X-ray nanomultiplier (Hb@Hf-Ce6) using a unique metallopolyphenol ligand interaction (Figure 13d). [104] This nano-RT multiplier delivered oxygen directly to deep tumor tissues to overcome the deep tumor hypoxic environment and further boosted -c) Reproduced with permission.…”