Immunostimulatory activities of<i>Haberlea rhodopensis</i>leaf extract on the specific antibody response: protective effects against γ-radiation-induced immunosuppression

Dobreva, Zlatka Georgieva; Popov, B.; Georgieva, S.; Stanilova, Spaska

doi:10.1080/09540105.2014.922935

Cited by 13 publications

(7 citation statements)

References 25 publications

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“…Groups of rabbits were formed from clinically healthy animal analogues in terms of age, live weight and physiological state. A dry type of feeding was used [19,22,25], access to water was free (nipple drinking was used). The method of growing the number of rabbits is in accordance with the scheme for conducting a scientific and economic experiment, which is presented in table 1.…”

Section: Results Of Production Approbationmentioning

confidence: 99%

Use of a complex of biologically active additives in complete compound feed for farm animals

Дранников

Iskusnykh

Дерканосова

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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In the organization of scientifically grounded feeding of farm animals, the use of compound feed balanced in terms of basic nutrients ensures an increase in the productivity of animals by 10-12%, and when enriched with biological additives that contribute to the safety of livestock, an increase in the physiological status and productivity of animals, their effectiveness increases by 25-30 %. There is the issue of providing the population with high-quality livestock products, which can only be obtained with adequate feeding, which contributes to the intensity of animal growth, productivity and a decrease in feed costs per unit of production. An important WHO recommendation is to limit the consumption of processed and red meat products, due to the increased risk of developing cancer of the gastrointestinal tract in humans. One of the alternatives to red meat is rabbit meat. Rabbit meat is rich in polyunsaturated fatty acids, which interfere with carcinogenesis, inducing apoptosis, controlling the cell cycle and eicosanoid production, and also inducing antiproliferative effects. The main problem in industrial rabbit breeding is maintaining a high immune status of rabbits to increase the safety of livestock, productivity and meat quality. The use of non-traditional biologically active additives from agroindustrial complex waste in the composition of compound feed has been insufficiently studied. It is necessary to qualitatively change the nature of the feed base through the creation and use of effective biologically active feed additives and probiotics that have a protective effect and the ability to optimize the metabolic processes of the body, treat and prevent diseases of the gastrointestinal tract. It is possible to restore normal intestinal microflora, improve the bioavailability of nutrients in compound feed and increase safety of livestock without the use of antibiotics for therapeutic and prophylactic purposes. The comparative assessment of the effectiveness of the action of biologically active additives in the composition of feed for the development of rabbit breeding is of undoubted scientific and practical importance.

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Section: Results Of Production Approbationmentioning

confidence: 99%

Use of a complex of biologically active additives in complete compound feed for farm animals

Дранников

Iskusnykh

Дерканосова

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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“…Numerous studies revealed that myconoside is a potent antioxidative modulator [ 13 ]. Extracts from H. rhodopensis have an immunomodulatory potential through ROS reduction in radiation-exposed rabbits [ 43 ], and mimic the ROS-induced apoptotic effect in the non-malignant HEK293 cell line and prostatic cancer cell line PC3 [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Biotechnologically-Produced Myconoside and Calceolarioside E Induce Nrf2 Expression in Neutrophils

Amirova

Dimitrova

Marchev

et al. 2021

IJMS

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The pathological manifestation of various diseases can be suppressed by the activation of nuclear factor erythroid 2 p45-related factor 2 (Nrf2), a transcriptional regulator of the cellular redox balance. Haberlea rhodopensis Friv. is a resurrection plant species endemic for Bulgaria, containing biologically active phenylethanoid glycosides that might possess antioxidant or redox activity. This study aimed to analyze the metabolic profile of in vitro cultured H. rhodopensis and to identify molecules that increase Nrf2 expression in bone marrow neutrophils. Fractions B, D, and E containing myconoside, or myconoside and calceolarioside E in ratios 1:0.6 and 0.25:1 were found to be the most active ones. Fraction B (200 µg/mL) improved neutrophil survival and strongly increased the Nrf2 intracellular level, while D and E, as well as, myconoside and calceolarioside E at the same ratios had a superior effect. Calceolarioside E (32 µg/mL) had stronger activity than myconoside, the effect of which was very similar to that of 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester (CDDO-Me), used as a positive control. These data indicate that both molecules, used alone or in combination have stimulatory activity on the endogenous Nrf2 level, indicating their therapeutic potential to regulate the cellular redox homeostasis oxidative stress-associated pathologies.

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“…Isolated-polysaccharides or polysaccharides fraction derived from plants often show anti-allergic activity (Ishihara, Oyamada, Matsushima, Murata, & Muraoka, 2005;Kobayashi et al 2004;Maruyama, Tamauchi, Hashimoto, & Nakano, 2005;Yoshida, Hirano, Wada, Takahashi, & Hattori, 2004). In addition, other immune-reactive molecules derived from plants have been found occasionally (Chin, Hung, Yang, Wanga, & Lin, 2015;Dobreva, Popov, Georgieva, & Stanilova, 1992). Further analysis of Sasa components will assist in identifying the anti-allergic substance in Sasa veitchii.…”

Section: Discussionmentioning

confidence: 99%

Sasa veitchiiextracts suppress 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice

Usuda

Fujii

Nonogaki

2016

Food and Agricultural Immunology

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We examined the therapeutic effect of the extract from Sasa veitchii leaves (Sasa extract: SE) on the allergic skin inflammation model. SE derived from 0.141 g (low dose) or 0.562 g (high dose) of the leaves was administered orally for 15 days. High dose of SE suppressed ear swelling response induced by repeated 2,4-dinitrofluorobenzene (DNFB) paintings, and both low and high doses of SE reduced infiltration of immune cells into the ear dermis. Although the number of T cells, Treg, CD4 + T cells and CD8 + T cells in draining lymph nodes (dLNs) was not changed by SE, IFN-γ secretion from dLN induced by concanavalin A or 2,4-dinitrobenzenesulfonic acid was suppressed by a high dose of SE while IL-10 levels remained unchanged. These results suggest that SE suppresses allergic skin inflammation via reducing IFN-γ secreted from immune cells, especially T cells. ARTICLE HISTORY

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Immunostimulatory activities ofHaberlea rhodopensisleaf extract on the specific antibody response: protective effects against γ-radiation-induced immunosuppression

Cited by 13 publications

References 25 publications

Use of a complex of biologically active additives in complete compound feed for farm animals

Use of a complex of biologically active additives in complete compound feed for farm animals

Biotechnologically-Produced Myconoside and Calceolarioside E Induce Nrf2 Expression in Neutrophils

Sasa veitchiiextracts suppress 2,4-dinitrofluorobenzene-induced contact hypersensitivity in mice

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