Immunostimulatory activity of stem bark of Kalopanax pictus in RAW 264.7 macrophage

Kim, Sunggun; Lee, Chung Hyeon; Yeo, Ji-Yun; Hwang, Kwang Woo; Park, Soyoung

doi:10.1016/j.hermed.2021.100504

Cited by 5 publications

(6 citation statements)

References 29 publications

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“…Cytokines are important mediators involved in modulating immune and inflammatory responses [42]. A variety of cytokines, including TNF-α, IL-1β, and IL-6, are potent immunomodulators in activated macrophages [47,48]. According to our findings, PGSP increased serum IL-1β, IL-6, and TNF-α levels.…”

Section: Plos Onesupporting

confidence: 55%

In vitro immune-enhancing effects of Platycodon grandiflorum combined with Salvia plebeian via MAPK and NF-κB signaling in RAW264.7 cells

Jang,

Kim,

Rod-in

et al. 2024

PLoS ONE

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The immune-enhancing activity of the combination of Platycodon grandiflorum and Salvia plebeian extracts (PGSP) was evaluated through macrophage activation using RAW264.7 cells. PGSP (250–1000 μg/mL) showed a higher release of NO in a dose-dependent manner. The results showed that PGSP could significantly stimulate the production of PGE2, COX-2, TNF-α, IL-1β, and IL-6 in RAW264.7 cells and promote iNOS, COX-2, TNF-α, IL-1β, IL-4, and IL-6 mRNA expression. Western blot analysis demonstrated that the protein expression of iNOS and COX-2 and the phosphorylation of ERK, JNK, p38, and NF-κB p65 were greatly increased in PGSP-treated cells. PGSP also promoted the phagocytic activity of RAW264.7 cells. All these results indicated that PGSP might activate macrophages through MAPK and NF-κB signaling pathways. Taken together, PGSP may be considered to have immune-enhancing activity and might be used as a potential immune-enhancing agent.

show abstract

Section: Plos Onesupporting

confidence: 55%

In vitro immune-enhancing effects of Platycodon grandiflorum combined with Salvia plebeian via MAPK and NF-κB signaling in RAW264.7 cells

Jang,

Kim,

Rod-in

et al. 2024

PLoS ONE

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show abstract

“…Several studies on functional substances with immune-enhancing activity have confirmed the effects of such molecules on the production of NO as well as the expression of iNOS, which are enzymes synthesizing them ( Eom et al, 2021 , Kim et al, 2022a ).…”

Section: Resultsmentioning

confidence: 96%

“…IL-1β belongs to the IL-1 subfamily of cytokines and is an essential cytokine against pathogens, responding to various infections, injuries, and immunological challenges ( Lopez-Castejon & Brough, 2011 ). Due to the functional properties of these cytokines, their effect on cytokine expression is often measured to determine the immune-modulating activity of the bioactive compound ( Jiang et al, 2021c , Kim et al, 2022a , Lee et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

“…In addition, macrophages involved in immune mediator production are mainly activated through the activation of several cell signaling pathways such as the nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) ( Geum et al, 2020 ). If the immune system is weakened and the macrophage function is not activated, the host's homeostasis can be fatally damaged ( Kim, Lee, Yeo, Hwang, & Park, 2022 ). Research on natural substances that can activate macrophages is currently underway ( Geum et al, 2020 , Jiang et al, 2021a , Kim et al, 2022a , Lee et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…If the immune system is weakened and the macrophage function is not activated, the host's homeostasis can be fatally damaged ( Kim, Lee, Yeo, Hwang, & Park, 2022 ). Research on natural substances that can activate macrophages is currently underway ( Geum et al, 2020 , Jiang et al, 2021a , Kim et al, 2022a , Lee et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Structural, physicochemical, and immune-enhancing properties of edible insect protein isolates from Protaetia brevitarsis larvae

Lee

Kim

et al. 2023

Food Chemistry: X

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Kalopanax septemlobus: its phytochemistry, pharmacology and toxicity (1966–2022)

Liu,

Ma,

Sun

et al. 2023

Fitoterapia

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Immunostimulatory activity of stem bark of Kalopanax pictus in RAW 264.7 macrophage

Cited by 5 publications

References 29 publications

In vitro immune-enhancing effects of Platycodon grandiflorum combined with Salvia plebeian via MAPK and NF-κB signaling in RAW264.7 cells

In vitro immune-enhancing effects of Platycodon grandiflorum combined with Salvia plebeian via MAPK and NF-κB signaling in RAW264.7 cells

Structural, physicochemical, and immune-enhancing properties of edible insect protein isolates from Protaetia brevitarsis larvae

Kalopanax septemlobus: its phytochemistry, pharmacology and toxicity (1966–2022)

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