Immunostimulatory Effect of Gold Nanoparticles Conjugated with Transmissible Gastroenteritis Virus

Староверов, С. А.; Vidyasheva, Irina V.; Габалов, К. П.; Василенко, О. А.; Ласкавый, В Н; Дыкман, Л. А.

doi:10.1007/s10517-011-1350-8

Cited by 51 publications

(37 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and the activation of immune response genes. Thus, in addition to early observations by Shukla et al 16 for bare GNPs, the published data [26][27][28][29] indicate a signicant role of surface coating in macrophage response aer GNP uptake.…”

Section: Interaction Of Gold Nanoparticles With Immune Cellsmentioning

confidence: 53%

“…The recognition of GNP-peptide conjugates was made more effective through toll-like receptors 4 (TLR-4) on the surface of the macrophages. Yet, Staroverov et al 28,29 demonstrated that both 15 nm nonconjugated GNPs and their conjugates with highand low-molecular-weight antigens, on entry into rat peritoneal macrophages, enhance their respiratory activity and the activity of macrophage mitochondrial enzymes ( Fig. 1).…”

Section: Interaction Of Gold Nanoparticles With Immune Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Immunological Properties of Gold Nanoparticles

Дыкман¹,

Khlebtsov²

2017

Gold Nanoparticles in Biomedical Applications

View full text Add to dashboard Cite

In the past decade, gold nanoparticles have attracted strong interest from the nanobiotechnological community owing to the significant progress made in robust and easy-to-make synthesis technologies, in surface functionalization, and in promising biomedical applications. These include bioimaging, gene diagnostics, analytical sensing, photothermal treatment of tumors, and targeted delivery of various biomolecular and chemical cargos. For the last-named application, gold nanoparticles should be properly fabricated to deliver the cargo into the targeted cells through effective endocytosis. In this review, we discuss recent progress in understanding the selective penetration of gold nanoparticles into immune cells. The interaction of gold nanoparticles with immune cell receptors is discussed. As distinct from other published reviews, we present a summary of the immunological properties of gold nanoparticles. This review also summarizes what is known about the application of gold nanoparticles as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. For each of the above topics, the basic principles, recent advances, and current challenges are discussed. Thus, this review presents a detailed analysis of data on interaction of gold nanoparticles with immune cells.Emphasis is placed on the systematization of data over production of antibodies by using gold nanoparticles and adjuvant properties of gold nanoparticles. Specifically, we start our discussion with current data on interaction of various gold nanoparticles with immune cells. The next section describes existing technologies to improve production of antibodies in vivo by using gold nanoparticles conjugated with specific ligands. Finally, we describe what is known about adjuvant properties of bare gold or functionalized nanoparticles. In the Conclusion section, we present a short summary of reported data and some challenges and perspectives.

show abstract

Section: Interaction Of Gold Nanoparticles With Immune Cellsmentioning

confidence: 53%

Section: Interaction Of Gold Nanoparticles With Immune Cellsmentioning

confidence: 99%

Immunological Properties of Gold Nanoparticles

Дыкман¹,

Khlebtsov²

2017

Gold Nanoparticles in Biomedical Applications

View full text Add to dashboard Cite

show abstract

“…Also, the formulation containing AuNPs, TT antigen, and immunostimulant Quillaja saponaria (QS, a normal immune stimulator) elicited enhanced immune responses after oral administration in mice . The increased titer of antibodies in animals immunized with transmissible gastroenteritis virus‐conjugated AuNRs was also reported . Wang et al conjugated a recombinant protein vaccine targeting human Nogo‐66 receptor (hNgR‐Fc) to 15 nm AuNPs to develop a therapeutic vaccine for spinal cord injury therapy.…”

Section: Gold Nanomaterialsmentioning

confidence: 98%

Functional Nanomaterials Can Optimize the Efficacy of Vaccines

Liu

Tian

et al. 2014

Small

View full text Add to dashboard Cite

Nanoscale materials can improve the efficacy of vaccines. Herein we review latest developments that use nanomaterials for vaccines. By highlighting the relationships between the nanoscale physicochemical characteristics and working mechanisms of nanomaterials, this paper shows the current status of the developments where researchers employ functional nanomaterials as vector and/or immunoregulators for vaccines. It also provides us some clues for improving the design and application of nanomaterials to optimize the efficacy of vaccines.

show abstract

“…The ability of gold nanoparticles to provoke a humoral immune response to weak immunogenic antigens and haptens seem of great interest [10]. There are some data on immune stimulating ability of gold nanoparticles conjugated with a TGE virus [11,12].…”

Section: Introductionmentioning

confidence: 99%

Study of immunogenic properties of transmissible gastroenteritis virus antigen conjugated to gold nanoparticles

Mezhenny

Староверов

Fomin

et al. 2016

JBPE

View full text Add to dashboard Cite

Abstract. There was performed the study of immunogenic properties of the transmissible gastroenteritis virus antigen conjugated to gold nanoparticles. In comparative immunobiological studies there was found that immunization of guinea pigs driven by the colloidal gold conjugated to transmissible gastroenteritis virus antigen of swine, leads to activation of the respiratory activity of lymphoid cells and peritoneal macrophages, which is directly related to increased activity of antibodyproducing cells and activation of antibody generating. The obtained data suggest that the colloid particles promote antigen presentation to the reticuloendothelial system organs. In addition, there was established that these carriers stimulate production of proinflammatory cytokines, which leads to a complete and consistent immune response of both cellular and humoral components of immune system.

show abstract

Immunostimulatory Effect of Gold Nanoparticles Conjugated with Transmissible Gastroenteritis Virus

Cited by 51 publications

References 11 publications

Immunological Properties of Gold Nanoparticles

Immunological Properties of Gold Nanoparticles

Functional Nanomaterials Can Optimize the Efficacy of Vaccines

Study of immunogenic properties of transmissible gastroenteritis virus antigen conjugated to gold nanoparticles

Contact Info

Product

Resources

About