Immunostimulatory properties of Toll-like receptor ligands in chickens

Paul, Michael St.; Brisbin, Jennifer T.; Abdul-Careem, Mohamed Faizal; Sharif, Shayan

doi:10.1016/j.vetimm.2012.10.013

Cited by 107 publications

(57 citation statements)

References 77 publications

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“…TLRs recognise the conserved microbial patterns such as flagellin, LPS, peptidoglycan in an efficient and non self reactive manner to initiate pro inflammatory cytokines. Role of TLR in the immunomodulation has been demonstrated and at least 10 TLRs have been identified in chickens, including TLR1A, 1B, 2A, 2B, 3, 4, 5, 7, 15 and 21 (Barjesteh et al, 2013;St Paul et al, 2013). Sunder et al (2014b) studied that supplementation of Noni and Kalmegh influenced the expression levels of TLR-2, TLR-3, TLR-4, TLR-5, TLR-15 and TLR-21 significantly (P<0.05).…”

Section: Morinda Citrifolia and Andrographis Paniculata On Expressionmentioning

confidence: 99%

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Sunder¹,

Sujatha²,

Kundu³

2016

JEBAS

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KEYWORDS Morinda citrifolia Livestock Poultry Growth Production Immunomodulatory Properties ABSTRACTMorinda citrifolia L. is commonly known as Noni and has been found to have wide range of medicinal properties. It is usually found in the coastal region in many countries including Andaman and Nicobar Islands and belongs to the family Rubiaceae. This small evergreen tree is widely grown and well adapted to the tropics and can grow in fertile, acidic, alkaline and saline affected soils. It tolerates high soil salinity and brackish water stagnation. All the components of this plant have high demand in case of alternative medicines and herbal medicines. Due to its high demand and as a source of revenue generation the detail study on its nutritional benefits and therapeutic values are essential for its commercial exploitation. More than 200 nutraceutical compounds have been identified from the plant. Morinda citrifolia is reported to have broad spectrum biological activities such as antimicrobial, immunomodualtory, antioxidant wound healing etc. Apart from the in-vitro scientific validation of the activities and in-vivo trial in some lab animal model, the plant has been used for livestock and poultry health and production. A lot of reviews have been written on the different uses of Noni, however, scientific review on the use of this plant on the growth, production, immunomodulator and other pharmacological activities of M. citrifolia in livestock and poultry has not been compiled. Therefore this review discusses the compilation of the work done on the use of M. citrifolia in livestock and poultry.

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Section: Morinda Citrifolia and Andrographis Paniculata On Expressionmentioning

confidence: 99%

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Sunder¹,

Sujatha²,

Kundu³

2016

JEBAS

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“…Toll-like receptors (TLRs) are the best characterized members of the PRR family [2]. Ten TLRs are present in chickens [3]. The interaction of TLRs with PAMPs leads to activation of intracellular signaling pathways and expression of type I interferons (IFNs) and pro-inflammatory cytokines [4].…”

Section: Q2mentioning

confidence: 99%

“…The immunostimulatory properties of TLR ligands have been studied in mammalian species and chickens [3,8]. TLR ligands have been used in mammals as therapeutic or prophylactic agents against several infectious diseases [9][10][11].…”

Section: Q2mentioning

confidence: 99%

Reduction of avian influenza virus shedding by administration of Toll-like receptor ligands to chickens

Barjesteh

Shojadoost

Brisbin

et al. 2015

Vaccine

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“…A few studies have demonstrated the immunomodulatory properties of the Toll-like receptor 21 adjuvant, CpG, in chickens [16,22], however, limited data are available regarding the evaluation of various doses of this adjuvant for enhancing the immunogenicity of AIV vaccines. Here we report that a dose of 2 g of CpG 2007, when administered intramuscularly with a formalin-inactivated H9N2 virus induces significantly higher serum antibody responses (HI and VN) compared to 20 g of CpG 2007, although the exact dosedependent mechanism of action requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Systemic immune responses to an inactivated, whole H9N2 avian influenza virus vaccine using class B CpG oligonucleotides in chickens

Singh

Alkie

Hodgins

et al. 2015

Vaccine

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Immunostimulatory properties of Toll-like receptor ligands in chickens

Cited by 107 publications

References 77 publications

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Reduction of avian influenza virus shedding by administration of Toll-like receptor ligands to chickens

Systemic immune responses to an inactivated, whole H9N2 avian influenza virus vaccine using class B CpG oligonucleotides in chickens

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