Immunosuppresive Factors in Cancer

Vaccination with hybrids of tumor and dendritic cells induces tumor‐specific T‐cell and clinical responses in melanoma stage III and IV patients

“…4 However, the response rates reported so far from cancer vaccination trials are not yet satisfying and progression during therapy as much as manifest cancer testifies to insufficient immune defenses. These deficiencies have been attributed, among other causes such as disease-related immune suppression 5 and immune evasion, 6 to poor immunogenicity of the tumors. 7 Fusion of tumor cells with antigen-presenting cells such as dendritic cells (DCs) 8 is meant to enhance the immunogenicity of antigenic tumors for induction of tumor-specific cytotoxic T cells (CTLs).…”