Immunosuppressants: implications in Orthodontics

Abstract

INTRODUCTION: There are medications capable of affecting bone metabolism and the rate of tooth movement. Among these medications are the immunosuppressants, which act by repressing the action of T lymphocytes, however they can cause bone loss and consequently lead to osteoporosis. Osteoporosis is a common complication following kidney, heart, liver or lung transplantation. The immunosuppressant treatment for preventing organ rejection after transplantation, in general, includes glucocorticoids, cyclosporine, tacrolimus, and sirolimus. All these drugs can have jeopardizing effects on bone mineral homeostasis and consequently influence tooth movement. In recent years, however, the increasing use of immunosuppressants has raised questions about their effects on bone metabolism in patients undergoing orthodontic treatment. OBJECTIVE: The objective of this review study was to inform orthodontists about the influence of immunosuppressants on bone metabolism and tooth movement

Wonders to Orthodontics - Drugs and Hormone

“…Long term Section: Dentistry medication therapy may accelerate tooth movement, thus orthodontic appliances must be adjusted customarily, or with greater frequency. [42] Estrogens These are female sex hormones that present in three forms; estradiole, estrone and estriole. Estrogens enhance bone formation by stimulating bone forming activity of osteoblasts and inhibit tumour necrosis factor, [43] interleukin 1and 6 which are involved in bone resorption.…”