Immunosuppressants in the Treatment of Pemphigus

Jabłońska, Stefania; Chorzelski, T; Błaszczyk, M

doi:10.1111/j.1365-2133.1970.tb15707.x

Cited by 77 publications

(36 citation statements)

References 24 publications

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“…Five had only cutaneous lesions with or without oral ulcers in addition to serological markers for SLE [22, 24, 31, 32, 34]. Seven patients had additional symptoms of SLE including renal, pleural, cardiac or CNS involvement [5,23,24,25,26, 28]. …”

Section: Resultsmentioning

confidence: 99%

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Concurrence of Systemic Lupus Erythematosus and Pemphigus: Coincidence or Correlation?

Malik¹,

Ahmed²

2007

Dermatology

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Background: Pemphigus and systemic lupus erythematosus (SLE) have previously been reported to coexist in the same patient. However, the relationship between the 2 diseases has not been elucidated. Objective: This review was conducted to examine the relationship between pemphigus and SLE when they occur together in the same patient. Methods: We conducted a retrospective review of the literature to identify previously reported cases of pemphigus and SLE coexisting in the same patient. The temporal relationship, clinical course, response to therapy and effects of 1 disease on the other were examined. Results: Eight patients with a dual diagnosis of pemphigus and SLE have been previously reported. Most were female and non-Caucasian, with a mean age of 41 years. In the 8 patients reviewed here clinical outcomes, organ system involvement and demographic profiles are more typical of SLE. Seven of these 8 patients had pemphigus vulgaris, and 1 had pemphigus erythematosus. The limited follow-up did not permit studying issues of disease interaction. An additional 17 patients with pemphigus have been reported who have features suggestive of SLE. Organ system involvement in these patients was less typical of SLE. Conclusion: It appears that a true dual diagnosis of pemphigus and SLE is less common than suggested by the literature. Comparing patients with only pemphigus or only SLE to those with both may provide insights into genetic predisposition and pathogenesis, and provide an opportunity to study the effects of drugs that influence their course.

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Section: Resultsmentioning

confidence: 99%

“…Three patients had myasthenia gravis and a thymoma [24, 29, 31], 1 had oral lichen planus and a thymoma [33], and 1 had a benign thymoma [30]. …”

Section: Resultsmentioning

confidence: 99%

Concurrence of Systemic Lupus Erythematosus and Pemphigus: Coincidence or Correlation?

Malik¹,

Ahmed²

2007

Dermatology

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“…196 In total, 13 case series have detailed its efficacy. [121][122][123][124][125][126][127][128][129][130][131][132]197 The available data on 116 patients with pemphigus vulgaris demonstrated a clinical improvement in 96 (83%)of the patients. [121][122][123][124][125][126] In patients with severe to moderately severe pemphigus vulgaris, methotrexate may be a useful maintenance therapy once control is achieved with steroid therapy, while allowing a lowering of the corticosteroid dose.…”

Section: American Academy Of Dermatology Guidelinesmentioning

confidence: 99%

The use of methotrexate in dermatology: a review

et al. 2011

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Methotrexate is a synthetic folic acid analogue valued for both its anti-proliferative and anti-inflammatory properties. Considered one of the original immune-modifying agents, it is used widely for the treatment of steroid-recalcitrant inflammatory diseases. While there are abundant studies documenting its efficacy in rheumatic diseases, the use of methotrexate for dermatological conditions, with the exception of psoriasis, has yet to be comprehensively explored. This two-part review firstly outlines current data concerning the pharmacology of methotrexate, including its mechanism of action, side-effect profile and recommended therapeutic approach, and, secondly, examines the emerging evidence for methotrexate's efficacy in a wide range of cutaneous disorders.

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“…Jablonska et a!. [10] reported good results with azathio prine alone in two cases of pemphigus erythematosus. Krakowski et al [11] was able to withdraw steroids in a patient with pemphigus, in whom the treatment was continued with azathioprine alone.…”

mentioning

confidence: 99%

“…These drugs include alkylating agents such as cyclophosphamide [8,12], folic acid antagonists such as methotrexate [10,13,14,16,17,21], and purine analogues such as azathioprine [2, 3, 6, 7, 10, 11, 18-20, 25, 27], There is little doubt that these immunosuppressive agents usually have a beneficial effect in the treatment of pemphigus and pemphigoid. Most authors recommend the combined administration of a corticosteroid and an immuno suppressive drug, the latter permitting a significant reduction in steroid dosage.…”

mentioning

confidence: 99%

Treatment of Pemphigus and Pemphigoid with Azathioprine

Dijk

Velde

1973

Dermatology

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The results obtained with azathioprine in 10 patients with pemphigus and pemphigoid are reported. Seven of these patients showed a very good response to azathioprine alone. In two patients an initial high dosage of corticosteroids could be considerably reduced after azathioprine was added. In one patient a short initial azathioprine treatment gave noimprovement. Further investigations on the clinical usefulness of this drug are recommended.

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Immunosuppressants in the Treatment of Pemphigus

Cited by 77 publications

References 24 publications

Concurrence of Systemic Lupus Erythematosus and Pemphigus: Coincidence or Correlation?

Concurrence of Systemic Lupus Erythematosus and Pemphigus: Coincidence or Correlation?

The use of methotrexate in dermatology: a review

Treatment of Pemphigus and Pemphigoid with Azathioprine

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