Immunosuppressants: Remarkable Microbial Products

Vaishnav, Preeti; Yoo, Young Je; Yoon, Yeo Joon; Demain, Arnold L.

doi:10.1002/9783527684403.ch4

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Antifungal Peptides1

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2017

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“…This could end up in activating and recruiting immune cells to the site of infection and thus boosting the host immune defense. Many originally isolated antifungal peptides possess immunosuppressive activity blocking the recipient’s immune system, thus preventing a transplanted organ rejection [ 82 , 83 ]. They are also employed to slow down the immune response in patients suffering from certain immune disorders [ 84 ].…”

Section: Antifungal Peptidesmentioning

confidence: 99%

Natural Antimicrobial Peptides as Inspiration for Design of a New Generation Antifungal Compounds

Bondaryk

Staniszewska

Zielińska

et al. 2017

JoF

105

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Invasive fungal infections are associated with high mortality rates, despite appropriate antifungal therapy. Limited therapeutic options, resistance development and the high mortality of invasive fungal infections brought about more concern triggering the search for new compounds capable of interfering with fungal viability and virulence. In this context, peptides gained attention as promising candidates for the antimycotics development. Variety of structural and functional characteristics identified for various natural antifungal peptides makes them excellent starting points for design novel drug candidates. Current review provides a brief overview of natural and synthetic antifungal peptides.

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Section: Antifungal Peptidesmentioning

confidence: 99%