Immunosuppression: A cause of porokeratosis?

Lederman, Josiane S.; Sober, Arthur J.; Lederman, Gilbert S.

doi:10.1016/s0190-9622(85)70146-6

Cited by 70 publications

(26 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2,3,11,13,14,16 In addition to organ transplantation, porokeratosis has been observed in various other types of immunosuppression, including that following immunosuppressive chemotherapy, electron beam radiation, 16,17 and systemic corticosteroids, 18 as well as in the setting of human immunodeficiency virus (HIV) infection 19 and hematopoietic malignancies. 2,3,11,13,14,16 In addition to organ transplantation, porokeratosis has been observed in various other types of immunosuppression, including that following immunosuppressive chemotherapy, electron beam radiation, 16,17 and systemic corticosteroids, 18 as well as in the setting of human immunodeficiency virus (HIV) infection 19 and hematopoietic malignancies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Porokeratosis of Mibelli following bone marrow transplantation

Alexis¹,

Busam²,

Myskowski³

2004

Int J Dermatol

View full text Add to dashboard Cite

Background Porokeratosis is a rare disorder of keratinization with both autosomal dominant and acquired forms. Immunosuppression has been associated with the development of porokeratosis in numerous case reports and series. To our knowledge, however, only five cases of porokeratosis have been reported following bone marrow transplantation. Results We report five cases of porokeratosis of Mibelli following bone marrow transplantation. The diagnosis of porokeratosis was made between 1 and 13 years post‐transplantation. The underlying malignancy in four of the five cases was leukemia, while the fifth patient had non‐Hodgkin's lymphoma. Porokeratosis developed during remission in the four leukemia patients, whereas, in the fifth patient, it occurred during a relapse of lymphoma. Conclusions Porokeratosis may develop following bone marrow transplantation. Our five cases double the number reported in the medical literature, and the incidence of porokeratosis following bone marrow transplantation may be significantly higher than previously recognized. As cutaneous carcinomas have been reported in association with porokeratosis, careful surveillance for porokeratosis in bone marrow transplant recipients is warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

“…2,3,[5][6][7][8] Basal cell carcinoma has also been observed at sites of porokeratosis. [11][12][13][14][15] In this series, we report five new cases of porokeratosis of Mibelli in patients who had undergone bone marrow transplantation. 2,10 It has been widely recognized following solid organ transplantation.…”

Section: Introductionmentioning

confidence: 99%

Porokeratosis of Mibelli following bone marrow transplantation

Alexis¹,

Busam²,

Myskowski³

2004

Int J Dermatol

View full text Add to dashboard Cite

show abstract

“…Ultraviolet radiation (UVR) may have played a part in the pathogenesis of some of the porokeratotic lesions but the patient has been exposed to other pathogenic agents that have been associated with porokeratosis including electron‐beam radiation 9 and immunosuppressive drugs 10 …”

Section: Reportmentioning

confidence: 99%

Poromas and porokeratosis in a patient treated for solid-organ and haematological malignancies

Шерман

Reed

Hollowood³

et al. 2010

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…There is evidence that porokeratosis is transmitted as an autosomal dominant trait with variable penetrance (1). Immunosuppression has recently been recognized as a precipitating factor for porokeratosis, especially porokeratosis of Mibelli (2) and disseminated superficial porokeratosis (DSP) (3,4). We report a patient with porokeratosis who had not received any immunosuppressive treatment and recently suffered from exacerbation of long-standing alcoholic liver cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Disseminated Superficial Porokeratosis in a Patient with Chronic Liver Disease

Park

Moon

Kim

1997

The Journal of Dermatology

View full text Add to dashboard Cite

A 55-year-old male suffering from liver cirrhosis presented with diffuse annular hyperkeratotic papules of abrupt onset on the trunk and extremities. Histopathologic examination revealed cornoid lamella and eosinophilic spongiosis. He did not receive any medications other than cephalosporin for spontaneous bacterial peritonitis. A review of the literature revealed that three cases developed porokeratosis when their liver function declined and that, in one case, the porokeratosis disappeared spontaneously with liver transplantation. Although the precise mechanism is unclear, there is evidence demonstrating immunoincompetence in cirrhosis. Even though we did not perform immunologic studies or exclude the possibility of drug-induced porokeratosis in our case, it is conceivable that porokeratosis can be triggered by immunosuppression due to liver cirrhosis per se.

show abstract

Immunosuppression: A cause of porokeratosis?

Cited by 70 publications

References 11 publications

Porokeratosis of Mibelli following bone marrow transplantation

Porokeratosis of Mibelli following bone marrow transplantation

Poromas and porokeratosis in a patient treated for solid-organ and haematological malignancies

Disseminated Superficial Porokeratosis in a Patient with Chronic Liver Disease

Contact Info

Product

Resources

About