Immunosuppression and Plasmapheresis in Chronic Progressive Multiple Sclerosis

Hauser, Stephen L.

doi:10.1001/archneur.1983.04050100027009

Cited by 19 publications

(9 citation statements)

References 24 publications

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“…It ranges from 95 to 100 in healthy adults [18] and was determined using the GaitRite System (CIR Systems, Inc., Havertown, PA) [19]. The ambulatory index is an ordinal, symptom-based rating scale for characterizing ambulatory capacity [20] and ranges from 0 (normal gait) to 9 (inability to walk alone).…”

Section: Clinical Testsmentioning

confidence: 99%

Differentiating shunt-responsive normal pressure hydrocephalus from Alzheimer disease and normal aging: pilot study using automated MRI brain tissue segmentation

et al. 2014

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Evidence suggests that normal pressure hydrocephalus (NPH) is underdiagnosed in day to day radiologic practice, and differentiating NPH from cerebral atrophy due to other neurodegenerative diseases and normal aging remains a challenge. To better characterize NPH, we test the hypothesis that a prediction model based on automated MRI brain tissue segmentation can help differentiate shunt-responsive NPH patients from cerebral atrophy due to Alzheimer disease (AD) and normal aging. Brain segmentation into gray and white matter (GM, WM), and intracranial cerebrospinal fluid was derived from pre-shunt T1-weighted MRI of 15 shunt-responsive NPH patients (9 men, 72.6 ± 8.0 years-old), 17 AD patients (10 men, 72.1 ± 11.0 years-old) chosen as a representative of cerebral atrophy in this age group; and 18 matched healthy elderly controls (HC, 7 men, 69.7 ± 7.0 years old). A multinomial prediction model was generated based on brain tissue volume distributions. GM decrease of 33% relative to HC characterized AD (P < 0.005). High preoperative ventricular and near normal GM volumes characterized NPH. A multinomial regression model based on gender, GM and ventricular volume had 96.3% accuracy differentiating NPH from AD and HC. In conclusion, automated MRI brain tissue segmentation differentiates shunt-responsive NPH with high accuracy from atrophy due to AD and normal aging. This method may improve diagnosis of NPH and improve our ability to distinguish normal from pathologic aging.

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Section: Clinical Testsmentioning

confidence: 99%

Differentiating shunt-responsive normal pressure hydrocephalus from Alzheimer disease and normal aging: pilot study using automated MRI brain tissue segmentation

et al. 2014

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“…A randomized controlled study of the use of cyclophosphamide was reported in 1983 by Hauser et al [38] based on the previous studies of Gonsette and Hommes. Patients with progressive MS were treated with a 2-to 3-week course of cyclophosphamide given intravenously 400 -500 mg/day in the hospital to achieve leukopenia of 2000/mm 3 plus ACTH and compared to a group that received ACTH alone or a group that received plasma exchange, ACTH, and oral cyclophosphamide.…”

Section: New England Journal 1983 Study and The Northeast Cooperativementioning

confidence: 99%

Immunosuppressive treatment in multiple sclerosis

Weiner

2004

Journal of the Neurological Sciences

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“…In the case of 7 criteria -not an unusual number -there may be as much as a 30% chance of at least one significant result at the 0.5% level occurring by chance [79]. With even more criteria such chance results are more likely, and this concern may have prompted the use of other summary indices such as the Ambulatory Index [82] and the Scripps Rating Scale [83].…”

Section: Objective and Subjective Measures In 23 Trials In Msmentioning

confidence: 99%

Analysing the Structure of 23 Clinical Trials in Multiple Sclerosis

Robinson¹

1987

Neuroepidemiology

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At present many trials appear to be using subjective data, but using these data in an unsystematic and inappropriate way. In this context it is not surprising that subjective measures have a generally low status amongst investigators in clinical trials in MS. A more careful approach to such subjective measures would enable trials to take into account a significantly wider range of features. Controlled trials can then act as an important psychosocial as well as biomedical laboratory in the understanding of MS.

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Immunosuppression and Plasmapheresis in Chronic Progressive Multiple Sclerosis

Cited by 19 publications

References 24 publications

Differentiating shunt-responsive normal pressure hydrocephalus from Alzheimer disease and normal aging: pilot study using automated MRI brain tissue segmentation

Differentiating shunt-responsive normal pressure hydrocephalus from Alzheimer disease and normal aging: pilot study using automated MRI brain tissue segmentation

Immunosuppressive treatment in multiple sclerosis

Analysing the Structure of 23 Clinical Trials in Multiple Sclerosis

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