Immunosuppression by cobra factor: Distribution, antigen-induced blast transformation and trapping of lymphocytes during in vivo complement depletion

Role of Complement in the Induction of Immunological Responses

“…This suggests that it involves the other cell types which function in T-dependent responses, B cells and macrophages, both of which bear complement receptors. (We (Pepys, Bell & Rowe 1976b) and others (Parish & Chilcott 1975) have been unable to confirm (Amaiz-Villena, Gyongyossy & Playfair 1974) that T cells have C3 receptors). In cooperation experiments in which CRL have been removed from the source of B cells, thymus-dependent antibody formation is generally suppressed while thymus-independent responses are not impaired (Dukor, Dietrich et al 1974, Amaiz-Villena, Playfair & Roitt 1975, although Parish has found the importance of CRL to be greater with a soluble than with a particulate antigen (Parish & Chilcott 1975).…”

Biologically active products from African Trypanosomes.

“…This may be a reflection of the failure of these organisms to generate fatty acids on autolysis. The finding that trypanosomes possess B-cell mitogens lends support to the hypothesis that these organisms function as polyclonal B-cell stimulators (9,106; Hazlett and Tizard, in press) and that it is this stimulation, in conjunction with a failure in the IgM-to-IgG switch, which accounts for the elevation in serum IgM levels in these diseases (139,141).…”