Immunosuppression by Combined Use of Cyclosporine and Resveratrol in a Rat Liver Transplantation Model

Mycophenolate Mofetil and Sirolimus in Hepatocyte Transplantation in an Experimental Model of Toxic Acute Liver Failure

“…In addition, Papalois et al [20] using MMF had comparatively better outcomes than when using cyclosporine. Moreover, Wu et al [21] using rats as experimental models found that the combination of cyclosporine and resveratol was better than monotherapy with cyclosporine. In another major study, Wu et al [22] demonstrated the central role that sirolimus may have in hepatocyte transplantation, since it promotes the engraftment of transplanted cells; however, it is necessary to replace it with another immunosuppressant during the phase of cell proliferation as sirolimus appears to have a negative effect on the proliferation of cells.…”

Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D‐dependent pathways

“…For instances, resveratrol was shown to enhance the immune response of mice treated with dinitrofluorobenzene in a delayed hypersensitivity assay (Feng et al, 2002), and resveratrol protected mice from infections by HSV1 and HSV2 (Docherty et al, 2004(Docherty et al, , 2005. Moreover, other studies showed that resveratrol suppresses T lymphocyte activation in rats with liver transplantation (Wu et al, 2005). Still other studies found that resveratrol may either enhance or suppress the activity of the cytotoxic T cells depending on the concentrations used (Falchetti et al, 2001).…”

“…Resveratrol has also been reported to possess antiviral effects against human immunodeficiency virus (HIV)-1 and herpes simplex virus (HSV) (Docherty et al, 2004(Docherty et al, , 2005. Higher doses of resveratrol have been shown to inhibit the production of nitric oxide (NO) and tumor necrosis factor (TNF)-a by macrophages (Tsai et al, 1999), and to reduce the severity of hepatic allograft rejection in rats (Wu et al, 2005). In contrast, low doses of resveratrol has been shown to enhance immune responses in mice by promoting the production of Th1 cytokines such as IL-12 and IFN-g, and by enhancing lymphocyte proliferation and IL-2 production (Feng et al, 2002).…”

Polyphenols in the treatment of inflammatory bowel disease and acute pancreatitis

“…[84][85][86] Oral curcumin and quercetin reduced acute rejection and immunosuppressive-drug side effects in a double-blind study on cadaveric renal transplant recipients. 87 Also of pertinence to the nutritional support of patients with IBD in a catabolic state is the finding that intraperitoneal administration of resveratrol for 10 days attenuated skeletal muscle cachexia in tumourbearing mice.…”