Immunosuppressive activity of a polychlorinated biphenyl preparation on the humoral immune response in guinea pigs

Vos, J.G.; Roij, Th. de

doi:10.1016/0041-008x(72)90011-7

Cited by 118 publications

(24 citation statements)

References 18 publications

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“…Feeding 50 ppm of Clophen A60 or Aroclor 1260, commercial PCB preparations, for 6 or 8 weeks in guinea pigs caused thymic atrophy and significantly reduced the antibody response to tetanus toxoid and the delayed hypersensitivity response to tuberculin (12,13). However, part of the immunosuppressive effects caused by feeding PCB may have been due to the presence of chlorinated dibenzofurans as toxic impurities in commercial PCB preparations.…”

Section: Discussionmentioning

confidence: 98%

Effects of polybrominated biphenyls (PBB) on immune response in rodents.

Luster¹,

Faith²,

Moore³

1978

Environ Health Perspect

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Studies were performed to investigate the effects of FireMaster FF-1, a chemical fire retardant consisting of a mixture of polybrominated biphenyls (PBB), on immune functions in mice and rats. Animals received 22 daily treatments of 0.03, 0.3, 3.0, or 30 mg PBB/kg body weight in a period covering 30 days. PBB exposure severely depressed cell mediated immunity in both mice and rats at the higher dosage levels as indicated by depressed responsiveness of splenic lymphocytes to mitogenic stimulation by polyclonal T-cell activators. Additionally, humoral immunity was depressed in mice at the 30.0 ppm dosage level. Assays for humoral immune functions included antibody production, serum immunoglobulin levels, and mitogenic stimulation of splenic lymphocytes to a polyclonal B-cell activator. These studies indicate that PBB exposure can lead to suppression of both humoral and particularly cell-mediated immune responses.

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Section: Discussionmentioning

confidence: 98%

Effects of polybrominated biphenyls (PBB) on immune response in rodents.

Luster¹,

Faith²,

Moore³

1978

Environ Health Perspect

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“…The residue levels of chlorinated hydrocarbons (PCBs, DDT and dieldrin) in humpback dolphins from the KwaZulu-Natal coast were reported to be higher than in any other marine mammal from the region (Cockcroft, 1989;Cockcroft et al, 1991;De Kock et al, 1994). These pollutants are known to be strongly immunosuppressive (Vos & De Roy, 1972), possibly carcinogenic (Martineau et al, 1994) and cause severe reproductive abnormalities (Reijnders, 1980;Subramanian et al, 1987). As both DDT and PCBs are in widespread use in many African and Asian countries, it is unlikely that the levels of coastal contamination will decrease in the foreseeable future.…”

Section: Implications For the Conservation Of Humpback Dolphinsmentioning

confidence: 99%

Conservation and management of humpback dolphins: the South African perspective*

Karczmarski¹

2000

ORX

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Population biology and socio-ecology of Indo-Pacific humpback dolphins Sousa chinensis were investigated during a 3-year study period in the Algoa Bay region, South Africa. The dolphins inhabit a narrow strip of coastal waters, mostly less than 15 m deep. Groups are small (mean = 7 animals) and their daily activities concentrate around shallow rocky reefs-the primary feeding grounds. Dependence on these restricted, shallow-water habitats is evident throughout the year. Site fidelity is generally weak and is subject to seasonal migration, although female site fidelity seems to be related to reproductive stage. Births occur predominantly in summer. The social system is highly fluid, structured to some degree by sex and age, 'matesearching' behaviour being the most likely male reproductive strategy. The dolphins inhabiting Algoa Bay are part of a substantially larger population that uses a considerable length of the coastal zone. Estimated population parameters are generally low, as are modelled population growth rates, and an increase in the population size seems unlikely. Humpback dolphins appear to be vulnerable to negative environmental pressure and the alteration/destruction of inshore habitats is probably among the greatest threats to them. Conservation of this species should be given high priority and be seen as an important part of integrated coastal zone management. Establishment of multiple-use management areas with controlled ecotourism and several priority sites declared as strict reserves seems to be the most effective conservation approach. In order to be successful, conservation and management policies need to recognize the needs and lifestyles of the local inhabitants.

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“…Animals were inoculated on Day 15 with the virus, and birds treated with PCB suffered a significantly higher mortality rate than control animals. Function studies of humoral and cell-mediated immunity were reported in guinea pigs with 60% chlorinated PCB compounds; 148,149 these studies were performed because of lymphopenia, thymus atrophy, and a reduction in the number of germinal centers in the spleens and lymph nodes after dermal application of PCB in rabbits. 150 Guinea pigs were fed diets containing 0, 10, and 50 ppm Aroclor 1260 for 8 weeks.…”

Section: Halogenated Biphenyls and Certain Pesticidesmentioning

confidence: 99%

“…150 Guinea pigs were fed diets containing 0, 10, and 50 ppm Aroclor 1260 for 8 weeks. 148 Animals were immunized with tetanus toxoid. Terminal body weights in the 50 ppm group were lower than the weights of controls.…”

Section: Halogenated Biphenyls and Certain Pesticidesmentioning

confidence: 99%

Immune Suppression as Related to Toxicology

Vos

2007

Journal of Immunotoxicology

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Immunosuppressive activity of a polychlorinated biphenyl preparation on the humoral immune response in guinea pigs

Cited by 118 publications

References 18 publications

Effects of polybrominated biphenyls (PBB) on immune response in rodents.

Effects of polybrominated biphenyls (PBB) on immune response in rodents.

Conservation and management of humpback dolphins: the South African perspective*

Immune Suppression as Related to Toxicology

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