Immunosuppressive Bibenzyl‐phenylpropane Hybrids from Dendrobium devonianum

Abstract

Two new bibenzyl‐phenylpropane hybrids, dendrophenols A and B (1 and 2), along with nine known bibenzyls, were isolated from the aerial part of Dendrobium devonianum Paxt. Their structures were determined by extensive spectroscopic methods and methylation. Bioassays revealed that compounds 1–9 were specifically immunosuppressive to T lymphocytes with IC50 values ranging from 0.41 to 9.4 μM, of which compounds 1 (IC50=1.62 μM) and 2 (IC50=0.41 μM) were promising immunosuppressive agents for T lymphocytes with the selectivity indices of 19.9 and 79.5, respectively.

Traceability Research on Dendrobium devonianum Based on SWATHtoMRM

“…Dendrobium devonianum is a characteristic Chinese herbal medicine produced in the Longling area of Yunnan, China, and it is also a Chinese plant that can be eaten as food [1][2][3]. Dendrobium devonianum has good biological health effects [4,5], and the geographical location where it grows has a large impact on it. Among them, the Longling area produces nationally important products, but the Dendrobium devonianum that grows in other parts of Yunnan is not a notable product [6].…”