Immunosuppressive Effect of Honey on the Induction of Allergen-Specific Humoral Antibody Response in Mice

Duddukuri, Govinda Rao; Kumar, Prasanna S.; Kumar, Veerendra B.; Athota, Rao R.

doi:10.1159/000237699

Cited by 17 publications

(6 citation statements)

References 17 publications

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“…For example, in mice, ovalbumin-specific IgE antibody responses elicited against different allergens were found to be completely suppressed by different sources of commercial honey. 18 Other animal studies showed the anti-allergic mechanism of honey involves the inhibition of IgE-mediated mast cell activation both in vivo and in vitro. 19 , 20 In another study, royal jelly, a principal food of the queen bee, suppressed antigen-specific IgE production and histamine release from mast cells, restored macrophage function, and improved Th1/Th2 cell responses, resulting in the suppression of allergic reactions in mice.…”

Section: Discussionmentioning

confidence: 99%

Ingestion of honey improves the symptoms of allergic rhinitis: evidence from a randomized placebo-controlled trial in the East Coast of Peninsular Malaysia

Asha'ari

Ahmad

Jihan

et al. 2013

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVESThe role of honey in the treatment of allergic rhinitis (AR) is controversial. We studied the complementary effect of ingestion of a high dose of honey, in addition to standard medications, on AR.DESIGN AND SETTINGSProspective randomized placebo-controlled study. Subjects were recruited from an otolaryngology clinic in 2 tertiary referral centers in the East coast of Peninsular Malaysia. The study period ranged from April 2010-April 2011.METHODSForty AR patients were divided equally into a case group and a control group. All the subjects received a daily dose of 10 mg of loratadine for 4 weeks. The case group ingested 1 g/kg body weight of honey daily in separate doses for the 4-week period. The control group ingested the same dose of honey-flavored corn syrup as placebo. AR symptoms were scored at the start, week 4, and week 8 of the study.RESULTSThere were no significant differences between the mean total symptom score of the case and the control groups at the start of the study. At week 4, both groups showed progressive improvement in the symptoms; at week 8, only the case group showed a continuous improvement in the symptom score. Only the group that ingested honey showed a significant improvement in individual AR symptoms. The improvement persisted for a month after the cessation of the treatment.CONCLUSIONHoney ingestion at a high dose improves the overall and individual symptoms of AR, and it could serve as a complementary therapy for AR.

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Section: Discussionmentioning

confidence: 99%

Ingestion of honey improves the symptoms of allergic rhinitis: evidence from a randomized placebo-controlled trial in the East Coast of Peninsular Malaysia

Asha'ari

Ahmad

Jihan

et al. 2013

Annals of Saudi Medicine

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“…Earlier, we have reported that intraperitoneal administration of honey in low doses suppresses the induction of ovalbumin-specific murine humoral antibody responses, as determined by passive cutaneous anaphylaxis (PCA) and Ouchterlony double immunodiffusion (Duddukuri et al, 1997). The substance also suppresses ovalbumin-specific IgG subclasses and other classes of antibody response as evaluated by ELISA (Duddukuri et al, 2001).…”

Section: Introductionmentioning

confidence: 95%

Suppressive Effect of Honey on Antigen/Mitogen Stimulated Murine T Cell Proliferation

Duddukuri

Rao

Athota

2002

Pharmaceutical Biology

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It has been reported that the intraperitoneal administration of honey suppressed the induction of antigen-specific humoral antibody response in mice as determined by passive cutaneous anaphylaxis and Ouchterlony double immunodiffusion tests. Hence, we studied the effect of honey on induction of antigen-specific IgG antibody response and found suppression in mice as determined by ELISA and also T cell proliferation in vitro. T cell proliferation induced by antigens such as ovalbumin, diphtheria toxoid and tetanus toxoid, as well as the mitogens concanavalin A and phytohemagglutinin, was significantly suppressed by various doses of natural and commercial honeys, as evaluated by 3 H-thymidine incorporation. Furthermore, the suppressive effect of honey was also confirmed on antigen-or mitogen-induced T cell proliferative responses using splenic T cells from different haplotypes of mice. The results obtained in this work confirm the antiproliferative activity of honey.

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“…Anti-OVA-specific IgE antibody titers were determined by passive cutaneous anaphylaxis as described elsewhere (Duddukuri et al, 1997;Amara et al, 1999).…”

Section: Passive Cutaneous Anaphylaxis (Pca)mentioning

confidence: 99%

“…In our laboratory, we have screened some natural products for immunomodulatory activity and observed that honey (Duddukuri et al, 1997) and Withania somnifera Dunal (Solanaceae) (Amara et al, 1999) were suppressing antigenspecific antibody response in mice. Furthermore, in our preliminary investigation, we also found that the phosphatebuffered saline (PBS) extract of Achyranthes aspera Linn.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Activity of Achyranthes aspera on the Elicitation of Antigen-Specific Murine Antibody Response

Vasudeva

Duddukuri

Sunil

et al. 2002

Pharmaceutical Biology

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The extract of Achyranthes aspera Linn. (Amaranthaceae) was found to enhance the induction of ovalbumin (OVA)-specific humoral antibody response in mice, on intraperitoneal injection of extract along with OVA. The antibody response was evaluated by passive cutaneous anaphylaxis (PCA) and ELISA for IgE and other classes or subclasses of antibodies, respectively. Furthermore, the plant extract was found to increase the induction of OVA-specific antibody response in a dose-dependent manner. A significant elevation of IgM, IgG 1 and IgG 3 antibodies was observed (p < 0.01); however, interestingly, the anti-OVA PCA titers were suppressed. The adjuvant property of the extract was further examined in different strains of mice and a significant elevation of the OVA-specific IgG antibody response in all strains tested was found. When the extracts of different parts of the herb were tested, the seed and root extracts appeared to exhibit relatively higher activity. These results confirm the immunostimulatory properties of Achyranthes aspera.Pharmaceutical Biology Downloaded from informahealthcare.com by Library of Health Sci-Univ of Il on 11/28/14For personal use only. a bPharmaceutical Biology Downloaded from informahealthcare.com by Library of Health Sci-Univ of Il on 11/28/14For personal use only.

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Immunosuppressive Effect of Honey on the Induction of Allergen-Specific Humoral Antibody Response in Mice

Cited by 17 publications

References 17 publications

Ingestion of honey improves the symptoms of allergic rhinitis: evidence from a randomized placebo-controlled trial in the East Coast of Peninsular Malaysia

Ingestion of honey improves the symptoms of allergic rhinitis: evidence from a randomized placebo-controlled trial in the East Coast of Peninsular Malaysia

Suppressive Effect of Honey on Antigen/Mitogen Stimulated Murine T Cell Proliferation

Immunomodulatory Activity of Achyranthes aspera on the Elicitation of Antigen-Specific Murine Antibody Response

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