Immunosuppressive effects of<i>Pteridium aquilinum</i>enhance susceptibility to urethane-induced lung carcinogenesis

Caniceiro, Beatriz Dorr; Latorre, Andréia Oliveira; Fukumasu, Heidge; Sanches, Daniel Soares; Haraguchi, Mitsue; Górniak, Silvana Lima

doi:10.3109/1547691x.2014.885619

Cited by 6 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 4 shows representative histological microphotographs as a function of scan timepoint for the histological analysis (LC) subgroup, and at 5 months for the NC group. Precancerous lesions classified as alveolar epithelial hyperplasia were observed at 1 month after urethane injection [ 22 ]. This was followed by a mixture of alveolar epithelial hyperplasia and atypical adenomatous hyperplasia at 2 months, and adenoma at 3 and 5 months.…”

Section: Resultsmentioning

confidence: 99%

Inflammation during Lung Cancer Progression and Ethyl Pyruvate Treatment Observed by Pulmonary Functional Hyperpolarized 129Xe MRI in Mice

Kimura

Utsumi

Shimokawa

et al. 2021

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

This study aimed to assess the suitability of hyperpolarized 129Xe (HPXe) MRI for noninvasive longitudinal evaluation of pulmonary function in preclinical lung cancer models. A mouse model of lung cancer (LC) was induced in 5 mice by intraperitoneal injection of urethane, while a negative-control (NC) mice (N = 5) was prepared by injection of saline solution. Longitudinal HPXe MRI was performed over a 5-month period to monitor lung ventilation and gas exchange. The treatment efficacy of ethyl pyruvate (EP), an anti-inflammatory drug, to the mouse LC model was monitored using HPXe MRI by commencing administration of EP pre (early-phase) and 1-month post (late-phase) injection of urethane (N = 5 mice for each group). Gas-exchange function in LC mice was significantly reduced at 1-month after urethane injection compared with NC mice administered with saline ( P < 0.01 ). Thereafter, it remained consistently lower than that of the NC group for the full 5-month measurement period. In contrast, the ventilation function of the LC model mice was not significantly different to that of the NC mice. Histological analysis revealed alveolar epithelial hyperplasia in LC mice alveoli at 1 month after urethane injection, and adenoma was confirmed 3 months after the injection. The early- and late-phase EP interventions were found to improve HPXe MRI metrics (reduced at 1 month postinjection of urethane) and significantly inhibit tumor growth. These results suggest that HPXe MRI gas-exchange metrics can be used to quantitatively assess changes in the precancerous lesion microenvironment and to evaluate therapeutic efficacy in cancer. Thus, HPXe MRI can be utilized to noninvasively monitor pulmonary pathology during LC progression and can visualize functional changes during therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Inflammation during Lung Cancer Progression and Ethyl Pyruvate Treatment Observed by Pulmonary Functional Hyperpolarized 129Xe MRI in Mice

Kimura

Utsumi

Shimokawa

et al. 2021

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

show abstract

“…Ptaquiloside is a DNA-alkylating agent, which causes point mutations, as well as structural and numeric chromosomal aberrations [ 19 , 20 , 21 ]. This toxin also has immunotoxic properties, contributing to reducing immune surveillance against newly arising neoplasms [ 22 , 23 , 24 ]. Other ferns containing ptaquiloside (e.g., Pteris spp.…”

Section: Prevalence and Aetiologymentioning

confidence: 99%

Molecular Markers in Urinary Bladder Cancer: Applications for Diagnosis, Prognosis and Therapy

Rasteiro¹,

Lemos²,

Oliveira

et al. 2022

Veterinary Sciences

View full text Add to dashboard Cite

Cancer of the urinary bladder is a neoplasm with considerable importance in veterinary medicine, given its high incidence in several domestic animal species and its life-threatening character. Bladder cancer in companion animals shows a complex and still poorly understood biopathology, and this lack of knowledge has limited therapeutic progress over the years. Even so, important advances concerning the identification of tumour markers with clinical applications at the diagnosis, prognosis and therapeutic levels have recently been made, for example, the identification of pathological BRAF mutations. Those advances are now facilitating the introduction of targeted therapies. The present review will address such advances, focusing on small animal oncology and providing the reader with an update on this field. When appropriate, comparisons will be drawn with bladder cancer in human patients, as well as with experimental models of the disease.

show abstract

“…Viruses, such as papillomavirus, might act as co-carcinogens [13]. In addition, ptaquiloside likely has an immunotoxic effect, as experimental studies with mice reported repression of the cytotoxic activity of natural killer cells [14,15]. However, ptaquiloside levels have not yet been determined in P. arachnoideum.…”

Section: Introductionmentioning

confidence: 99%

Ptaquiloside and Pterosin B Levels in Mature Green Fronds and Sprouts of Pteridium arachnoideum

Ribeiro¹,

Keller

Soto-Blanco

2020

Toxins

View full text Add to dashboard Cite

Pteridium arachnoideum, a fern of the Pteridium aquilinum species complex found in South America, is responsible for several different syndromes of poisoning. Cases of bovine enzootic hematuria and upper alimentary squamous cell carcinoma are both frequent occurrences in Brazil, whereas only bovine enzootic hematuria is noted with any frequency around the world. The reason for the high frequency of upper alimentary squamous cell carcinoma in Brazil is not currently known. One possible explanation may be the higher levels of ptaquiloside and pterosin B in Brazilian Pteridium than those present in the plant in other countries. However, these levels have not yet been determined in P. arachnoideum. Thus, the present study aimed to measure and compare ptaquiloside and pterosin B levels in mature green fronds and sprouts of P. arachnoideum collected from different locations in Brazil. Samples of P. arachnoideum were collected from the states of Minas Gerais and Rio Grande do Sul. A total of 28 mature leaf samples and 23 sprout samples were used. The mean concentrations of ptaquiloside and pterosin B present in the mature green fronds of P. arachnoideum ranged from 2.49 to 2.75 mg/g and 0.68 to 0.88 mg/g, respectively; in P. arachnoideum sprouts, mean concentrations of ptaquiloside and pterosin B ranged from 12.47 to 18.81 mg/g, and 4.03 to 10.42 mg/g for ptaquiloside and pterosin B, respectively. Thus, ptaquiloside and pterosin B levels in P. arachnoideum samples collected in Brazil were higher in sprouts than in mature green fronds, as observed in other countries. However, there was no variation in ptaquiloside levels among plants collected from different cities in Brazil. The high frequency of upper alimentary squamous cell carcinoma in Brazilian cattle may not be attributed to greater levels of ptaquiloside and pterosin B in P. arachnoideum than in other Pteridium species in other countries.

show abstract

Immunosuppressive effects ofPteridium aquilinumenhance susceptibility to urethane-induced lung carcinogenesis

Cited by 6 publications

References 28 publications

Inflammation during Lung Cancer Progression and Ethyl Pyruvate Treatment Observed by Pulmonary Functional Hyperpolarized 129Xe MRI in Mice

Inflammation during Lung Cancer Progression and Ethyl Pyruvate Treatment Observed by Pulmonary Functional Hyperpolarized 129Xe MRI in Mice

Molecular Markers in Urinary Bladder Cancer: Applications for Diagnosis, Prognosis and Therapy

Ptaquiloside and Pterosin B Levels in Mature Green Fronds and Sprouts of Pteridium arachnoideum

Contact Info

Product

Resources

About