Immunosuppressive factors in pregnancy serum: A preliminary report.

Okamura, Koji; Kuramoto, Masaru; Hamazaki, Yoko; Takahashi, Katsuyuki; Suzuki, Masakuni

doi:10.1620/tjem.130.11

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Although pregnancy plasma has been observed to have potent suppressive activity (27)(28)(29)(30)(31)(32)(33), we conclude from these analyses that depressed LT responses are apparent during pregnancy both in autologous and heterologous plasma, and that LT depression is not simply due to immunosuppressive activity of pregnancy plasma.…”

Section: Resultsmentioning

confidence: 69%

Depression of the lymphocyte transformation response to microbial antigens and to phytohemagglutinin during pregnancy.

Brunham¹,

Martín²,

Hubbard³

et al. 1983

J. Clin. Invest.

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A B S T R A C T Lymphocyte transformation (LT) responses to Chlamydia trachomatis, to four other microbial antigens, and to phytohemagglutinin (PHA) were studied in 201 women during pregnancy and/or 3-18 wk postpartum. The LT responses to all stimulants tested were significantly depressed during pregnancy when compared with postpartum LT responses. This difference occurred whether LT assays were performed in autologous or pooled heterologous plasma collected from nonpregnant donors. Among women studied in the third trimester and again postpartum, the autologous LT stimulation index (LTSI) rose from 1.7 to 3.4 (P < 0.001) with C. trachomatis elementary body antigen, from 3.7 to 7.9 (P < 0.001) with Candida albicans cell wall extract, from 4.5 to 7.8 (P = 0.008) with streptokinase-streptodornase, from 1.7 to 3.0 (P = 0.007) with fluid tetanus toxoid, from 1.7 to 2.8 (P = 0.046) with mumps virus skin test antigen, from 35.5 to 87.0 (P < 0.001) with PHA (2 ,ug/ml), and from 107.2 to 181.9 (P = 0.007) with PHA (10 ,g/ml). LT responses to C. trachomatis were compared in 52 pregnant women and 58 nonpregnant women; all the women had C. trachomatis isolated at the time of LT assay. Using either plasma supplement, the mean LTSI with C. trachomatis antigen was significantly higher in nonpregnant women than in pregnant women, regardless of trimester (P < 0.001). Among 12 women who were

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