Immunoteratology of chlordane: Cell-mediated and humoral immune responses in adult mice exposed in utero

Spyker-Cranmer, J M; Barnett, John B.; Avery, D L; Cranmer, Morris F.

doi:10.1016/0041-008x(82)90141-7

Cited by 54 publications

(12 citation statements)

References 12 publications

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“…Gestational exposure to tetrachlorodibenzo-p-dioxin resulted in a severe and persistent thymic atrophy (Faith and Moore, 1977;Fine et al, 1989), decreased thymic cellularity (Holladay et al, 1991;Vos and Luster, 1989), and quantitative alterations in the number of thymocytes expressing CD4 and CD8 cell-surface antigens (Blaylock et al, 1992). Mice exposed in utero to the organochlorine pesticide chlordane showed a profound suppression of the delayed-type hypersensitivity response and a depression in their mixed lymphocyte reactivity responses (Barnett et al, 1985;Spyker-Cranmer et al, 1982).…”

Section: Introductionmentioning

confidence: 95%

Gestational Exposure to Loud Noise Alters the Development and Postnatal Responsiveness of Humoral and Cellular Components of the Immune System in Offspring

Sobrian

Vaughn

Ashe

et al. 1997

Environmental Research

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Section: Introductionmentioning

confidence: 95%

Gestational Exposure to Loud Noise Alters the Development and Postnatal Responsiveness of Humoral and Cellular Components of the Immune System in Offspring

Sobrian

Vaughn

Ashe

et al. 1997

Environmental Research

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“…These PCBs, including 3,3',4,4'-tetrachlorobiphenyl (TCB), 3,3',4,4',5-pentachlorobiphenyl (PeCB), and 3,4,5,3',4',5'-HCB, bind the Ah receptor with relatively high affinity (though with less avidity than TCDD) (50). Mono There are reports that document developmental immunotoxicity of certain monocyclic and polycyclic halogenated pesticides and pesticide contaminants, including the fungicide hexachlorobenzene (51); the herbicide contaminant 3,3',4,4'-tetrachloroazoxybenzene (52); and the insecticides hexachlorocyclohexane (53), diazinon, and carbofuran (54) and chlordane (55).…”

Section: Development Of the Immune Systemmentioning

confidence: 99%

Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure.

Holladay

Smialowicz

2000

Environ Health Perspect

238

177

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Fetal and early postnatal life represent critical periods in vertebrate immune system development. Disruption of such development by perinatal immunotoxic chemical exposure has been widely described in experimental animal models. The resultant inhibited postnatal immune responses in such animals are often more dramatic and persistent than those after exposure during adult life. Further, recent reports suggest that prenatal exposure to immunotoxicants may exacerbate postnatal aberrant immune responses (e.g., hypersensitivity disorders and autoimmune disease) in genetically predisposed rodents. Limited information is available regarding the possibility of inhibited postnatal immune capacity in humans as a result of developmental immunotoxicant exposure. The multifactorial nature of hypersensitivity and autoimmune responses will further complicate the elucidation of possible relationships between chemical exposure during ontogeny of the human immune system and immune-mediated disease later in life. Taken together, however, the available animal data suggest the potential for altered postnatal immune function in humans exposed to immunotoxicants (e.g., environmental chemicals and therapeutic agents) during fetal and/or early postnatal life.

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“…However, studies in laboratory rodents suggest that perinatal treatment of animals with a variety of immunotoxic compounds may have more dramatic and persistent effects on subsequent immune function than does exposure during adult life [see review by Holladay and Luster (1)]. For example, studies show that prenatal exposure of mice to the organochlorine insecticide chlordane results in significant depression of cell-mediated immune responses in offspring that persist for at least 100 days after birth (2,3). Alterations in the formation of bone marrow colonies in these mice have been observed to persist up to 200 days of age (4).…”

Section: Introductionmentioning

confidence: 99%

Alterations in fetal thymic and liver hematopoietic cells as indicators of exposure to developmental immunotoxicants.

Holladay

Luster

1996

Environ Health Perspect

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Recent studies indicate that immune development in humans and other species may be altered after perinatal exposure to immunotoxic environmental contaminants. However, limited information is available regarding appropriate tests that may adequately detect developmental immunotoxic compounds. Experiments in which pregnant laboratory rodents were exposed to a variety of immunotoxic environmental agents indicate that fetal thymus and liver immune cells may be quantitatively and qualitatively altered by immunotoxicant exposure and, thus, may serve as sensitive markers of developmental immunotoxicant exposure. In particular, depression of fetal thymic cell counts appears to be a common event following gestational exposure to immunotoxicants that produce this response in adult animals. Total hematopoietic cell counts in fetal liver, however, may be a poor indicator of immunotoxicant exposure. Altered marker expression in both fetal thymus and liver appears to be a highly sensitive indicator of gestational immunotoxicant exposure. Together, these reports suggest that immune tests with high predictability for immunosuppression in adults may also be appropriate for the detection of developmental immunotoxic agents.

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Immunoteratology of chlordane: Cell-mediated and humoral immune responses in adult mice exposed in utero

Cited by 54 publications

References 12 publications

Gestational Exposure to Loud Noise Alters the Development and Postnatal Responsiveness of Humoral and Cellular Components of the Immune System in Offspring

Gestational Exposure to Loud Noise Alters the Development and Postnatal Responsiveness of Humoral and Cellular Components of the Immune System in Offspring

Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure.

Alterations in fetal thymic and liver hematopoietic cells as indicators of exposure to developmental immunotoxicants.

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