Immunotherapeutic Applications of NK Cells

Davis, Carter T.; Rizzieri, David A.

doi:10.3390/ph8020250

Cited by 19 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CD57 + NK cells can induce apoptosis via two main mechanisms: the release of granzymes and perforins by granules towards the target cell and death signaling through TNF receptor family members. 28 Thus, the larger number of CD57 + NK cells in atrophic lesions suggests that these cells play an important role in apoptosis of the cystic epithelium, participating in the homeostatic control of the lesion.…”

Section: Cd57mentioning

confidence: 99%

Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts

et al. 2017

View full text Add to dashboard Cite

The aim of this study was to compare the number of CD57 + natural killer (NK) cells and CD8 + T lymphocytes between periapical granulomas (PGs) and radicular cysts (RCs). Twenty-fives cases of PGs and 25 of RCs were submitted to histological analysis and immunohistochemistry using anti-CD57 and anti-CD8 biomarkers. Positive cells were counted in 10 fields (400× magnification) and the median value was calculated for each case. Statistical tests were used to evaluate differences in the number of CD57+ NK cells and CD8 + T lymphocytes according to type of lesion, intensity of the infiltrate and thickness of the lining epithelium. The number of CD57 + NK cells and CD8 + T lymphocytes was higher in PGs than in RCs (p = 0.129 and p = 0.541, respectively). Comparison of the number of CD57 + NK cells in atrophic and hyperplastic epithelium revealed a larger number of cells in the atrophic epithelium (p = 0.042). A larger number of CD57 + NK cells and CD8 + T lymphocytes were observed in grade III infiltrates compared to grade I/II (p = 0.145 and p = 0.725, respectively). CD8 + T lymphocytes were more prevalent than CD57 + NK cells in most cases when PGs and RCs were analyzed separately or in combination (p < 0.0001). CD57+ NK cells and CD8 + T lymphocytes play a key role in antiviral defense and the presence of these cells supports evidence suggesting the participation of these microorganisms in the pathogenesis of PGs and RCs. The response mediated by CD8 + T lymphocytes was more frequent, indicating greater participation of the adaptive immunity in these chronic lesions.

show abstract

Section: Cd57mentioning

confidence: 99%

Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This recognition helps initiate inhibitory or activating cytotoxic signaling in natural killer (NK) cells (and some T cells), utilizing an intracellular immunoreceptor tyrosine-based inhibitory or activation motif (ITIM or ITAM), respectively 2,3 . NKs and their KIR receptors are essential to human health and their genes impact infections (including HIV/AIDs), pregnancy, autoimmune diseases, transplantation, and immunotherapy [3][4][5][6] . NK cells induce cytotoxicity against infected or abnormal cells and they release cyto-and chemo-kines as part of a larger immune reaction.…”

Section: Introductionmentioning

confidence: 99%

Revealing Complete ComplexKIRHaplotypes Phased by Long-read Sequencing Technology

Roe

Vierra-Green

Pyo

et al. 2017

Preprint

View full text Add to dashboard Cite

The killer cell immunoglobulin-like receptor (KIR) region of human chromosome 19 contains up to sixteen genes for natural killer (NK) cell receptors that recognize human leukocyte antigen (HLA)/peptide complexes and other ligands. The KIR proteins fulfill functional roles in infections, pregnancy, autoimmune diseases, and transplantation. However, their characterization remains a constant challenge. Not only are the genes highly homologous due to their recent evolution by tandem duplications, but the region is structurally dynamic due to frequent transposon-mediated recombination. A sequencing approach that precisely captures the complexity of KIR haplotypes for functional annotation is desirable.We present a unique approach to haplotype the KIR loci using Single Molecule, Real-Time (SMRT®) Sequencing. Using this method, we have -for the first time -comprehensively sequenced and phased sixteen KIR haplotypes from eight individuals without imputation. The information revealed four novel haplotype structures, a novel gene-fusion allele, novel and confirmed insertion/deletion events, a homozygous individual, and overall diversity for the structural haplotypes and their alleles.These KIR haplotypes augment our existing knowledge by providing high-quality references, evolutionary informers, and source material for imputation. The haplotype sequences and gene annotations provide alternative loci for the KIR region in the human genome reference GrCh38.p8.

show abstract

“…Intestinal dendritic cells and macrophages secrete IL-6 , IL-23 and IL-12 to induce the development of TH1 and TH17 cells, the latter of which can transition into the former as a result of IL-23 or IL-12 signaling. Intestinal innate lymphoid cells, including NK cells [10], lymphoid tissue inducer (LTi) cells, and γδIELs, respond to proinflammatory cytokines to upregulate IL-22, which helps protect the epithelial barrier, and IL-17A and IL-17F, which are involved in neutrophil recruitment [9].…”

Section: Reciprocal Interactions and Local Immunitymentioning

confidence: 99%

The Microbiome: Evolutionary Perspective and Symbiogenesis

Islas-Rodríguez

Carballo-Lago

2015

Open Life Sciences

View full text Add to dashboard Cite

Abstract:The main function of the Immune System (IS) in metazoans is to protect them against invading microorganisms, which are considered from this perspective as competitors that reduce the availability of resources, cause tissue damage and essentially threaten their adaptability. This relationship is seen as a low intensity perpetual armed war, related to the hypothesis of the "Red Queen". This view suggests that the metazoans' IS has evolved under a selective pressure imposed by microorganisms of the microbiota, that whether infectious or not, have co-evolved with the host's IS in an evolutionary symbiogenesis, with reciprocal interactions that have developed local immunity. The microbiota changes with age and communicates with the brain. The above mentioned implies that we are witnessing the birth of a new scientific discipline that could be termed microbial anthropology, and several perspectives that includes the change of our perception of health and established the fundamentals for the use of microorganisms as therapeutic agents. In order for these therapies to succeed considerable information must be available about our microbiota, such as changes during pregnancy, the effects of antibiotic use, new methods for in vitro cultivation and the host-commensal dynamics.

show abstract

Immunotherapeutic Applications of NK Cells

Cited by 19 publications

References 29 publications

Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts

Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts

Revealing Complete ComplexKIRHaplotypes Phased by Long-read Sequencing Technology

The Microbiome: Evolutionary Perspective and Symbiogenesis

Contact Info

Product

Resources

About